2j44 - Revision history

OCA at 14:33, 13 December 2023

OCA — Wed, 13 Dec 2023 14:33:42 GMT

←Older revision		Revision as of 14:33, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2j44' size='340' side='right'caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2j44' size='340' side='right'caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900009:alpha-maltotriose'>PRD_900009</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [https://pdbe.org/2j44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [https://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [https://pdbe.org/2j44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [https://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PULA_STRPN PULA_STRPN] Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells (PubMed:21565699). Hydrolyzes the alpha-1,6-branchpoints of glycogen (PubMed:20497336, PubMed:21565699). Hydrolyzes pullulan. Does not hydrolyze dextran (PubMed:20497336). Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific carbohydrate-binding protein, which binds to amylose (pure alpha-(1,4)-linked glucose), amylopectin (alpha-(1,4)-linked glucose with alpha-(1,6) branch points), pullulan (linear polymer of mixed alpha-(1,4)- and alpha-(1,6)-linked glucose) and glycogen (similar to amylopectin with more frequent alpha-(1,6) branch points) in vitro. Does not bind to dextran (a linear polymer of alpha-(1,6)-linked glucose) (PubMed:17187076).[UniProtKB:A0A0H2ZL64]<ref>PMID:17187076</ref> <ref>PMID:20497336</ref> <ref>PMID:21565699</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boraston, A B]]
-	[[Category: Bueren, A Lammerts van]]
-	[[Category: Burke, R D]]
-	[[Category: Higgins, M]]
-	[[Category: Wang, D]]
-	[[Category: Carbohydrate-binding module]]
-	[[Category: Glycogen binding]]
-	[[Category: Pullulanase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: ~~Virulence~~]]	+	[[Category: Boraston AB]]
		+	[[Category: Burke RD]]
		+	[[Category: Higgins M]]
		+	[[Category: Lammerts van Bueren A]]
		+	[[Category: Wang D]]

OCA at 08:01, 19 January 2022

OCA — Wed, 19 Jan 2022 08:01:09 GMT

←Older revision		Revision as of 08:01, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2j44' size='340' side='right'caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2j44' size='340' side='right'caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [~~http~~://pdbe.org/2j44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [https://pdbe.org/2j44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [https://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:39, 15 April 2020

OCA — Wed, 15 Apr 2020 07:39:34 GMT

←Older revision		Revision as of 07:39, 15 April 2020
Line 1:		Line 1:

	==Alpha-glucan binding by a streptococcal virulence factor==		==Alpha-glucan binding by a streptococcal virulence factor==
-	<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2j44' size='340' side='right'caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://pdbe.org/2j44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://pdbe.org/2j44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Bueren, A Lammerts van]]		[[Category: Bueren, A Lammerts van]]

OCA at 07:17, 11 July 2018

OCA — Wed, 11 Jul 2018 07:17:19 GMT

←Older revision		Revision as of 07:17, 11 July 2018
Line 1:		Line 1:
-	==~~ALPHA~~-~~GLUCAN BINDING BY A STREPTOCOCCAL VIRULENCE FACTOR~~==	+
		+	==Alpha-glucan binding by a streptococcal virulence factor==
	<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://pdbe.org/2j44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://pdbe.org/2j44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j44 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j44_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j44_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
-	[[Category: Bueren, A Lammerts ~~Van~~]]	+	[[Category: Bueren, A Lammerts van]]
	[[Category: Burke, R D]]		[[Category: Burke, R D]]
	[[Category: Higgins, M]]		[[Category: Higgins, M]]

OCA at 06:49, 8 February 2016

OCA — Mon, 08 Feb 2016 06:49:33 GMT

←Older revision		Revision as of 06:49, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j44 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:58, 10 September 2015

OCA — Thu, 10 Sep 2015 08:58:14 GMT

←Older revision		Revision as of 08:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://pdbe.org/2j44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j44" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus pneumoniae]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Bueren, A Lammerts Van]]		[[Category: Bueren, A Lammerts Van]]
Line 37:		Line 37:
	[[Category: Glycogen binding]]		[[Category: Glycogen binding]]
	[[Category: Pullulanase]]		[[Category: Pullulanase]]
		+	[[Category: Streptococcus pneumoniae]]
	[[Category: Virulence]]		[[Category: Virulence]]

OCA at 17:08, 19 January 2015

OCA — Mon, 19 Jan 2015 17:08:12 GMT

←Older revision		Revision as of 17:08, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: Boraston, A B.]]	+	[[Category: Boraston, A B]]
-	[[Category: Bueren, A Lammerts Van.]]	+	[[Category: Bueren, A Lammerts Van]]
-	[[Category: Burke, R D.]]	+	[[Category: Burke, R D]]
-	[[Category: Higgins, M.]]	+	[[Category: Higgins, M]]
-	[[Category: Wang, D.]]	+	[[Category: Wang, D]]
	[[Category: Carbohydrate-binding module]]		[[Category: Carbohydrate-binding module]]
	[[Category: Glycogen binding]]		[[Category: Glycogen binding]]
	[[Category: Pullulanase]]		[[Category: Pullulanase]]
-	[[Category: Streptococcus pneumoniae]]
	[[Category: Virulence]]		[[Category: Virulence]]

OCA at 10:14, 30 September 2014

OCA — Tue, 30 Sep 2014 10:14:36 GMT

←Older revision		Revision as of 10:14, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2j44.~~png\|left~~\|200px]]	+	==ALPHA-GLUCAN BINDING BY A STREPTOCOCCAL VIRULENCE FACTOR==
		+	<StructureSection load='2j44' size='340' side='right' caption='[[2j44]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J44 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j44 RCSB], [http://www.ebi.ac.uk/pdbsum/2j44 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j44_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability of pathogenic bacteria to recognize host glycans is often essential to their virulence. Here we report structure-function studies of previously uncharacterized glycogen-binding modules in the surface-anchored pullulanases from Streptococcus pneumoniae (SpuA) and Streptococcus pyogenes (PulA). Multivalent binding to glycogen leads to a strong interaction with alveolar type II cells in mouse lung tissue. X-ray crystal structures of the binding modules reveal a novel fusion of tandem modules into single, bivalent functional domains. In addition to indicating a structural basis for multivalent attachment, the structure of the SpuA modules in complex with carbohydrate provides insight into the molecular basis for glycogen specificity. This report provides the first evidence that intracellular lung glycogen may be a novel target of pathogenic streptococci and thus provides a rationale for the identification of the streptococcal alpha-glucan-metabolizing machinery as virulence factors.

-	~~{{STRUCTURE_2j44\| PDB=2j44 \| SCENE= }}~~	+	Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors.,van Bueren AL, Higgins M, Wang D, Burke RD, Boraston AB Nat Struct Mol Biol. 2007 Jan;14(1):76-84. Epub 2006 Dec 24. PMID:17187076<ref>PMID:17187076</ref>

-	~~===ALPHA-GLUCAN BINDING BY A STREPTOCOCCAL VIRULENCE FACTOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17187076}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2j44]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017187076<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]

OCA: Protected "2j44" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:42:48 GMT

Protected "2j44" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:42, 7 January 2013

OCA at 14:42, 7 January 2013

OCA — Mon, 07 Jan 2013 14:42:44 GMT

←Older revision		Revision as of 14:42, 7 January 2013
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-	{{Seed}}
	[[Image:2j44.png\|left\|200px]]		[[Image:2j44.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2j44", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2j44\| PDB=2j44 \| SCENE= }}		{{STRUCTURE_2j44\| PDB=2j44 \| SCENE= }}

	===ALPHA-GLUCAN BINDING BY A STREPTOCOCCAL VIRULENCE FACTOR===		===ALPHA-GLUCAN BINDING BY A STREPTOCOCCAL VIRULENCE FACTOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17187076}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17187076 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17187076}}		{{ABSTRACT_PUBMED_17187076}}

	==About this Structure==		==About this Structure==
-	~~2J44~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA].	+	[[2j44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J44 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17187076~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017187076</ref><references group="xtra"/>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]
Line 35:		Line 23:
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Virulence]]		[[Category: Virulence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:56:47 2009''