2j79 - Revision history

OCA at 14:37, 13 December 2023

OCA — Wed, 13 Dec 2023 14:37:04 GMT

←Older revision		Revision as of 14:37, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2j79' size='340' side='right'caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='2j79' size='340' side='right'caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [https://pdbe.org/2j79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [https://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [https://pdbe.org/2j79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [https://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
-	[[Category: Beta-glucosidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Davies, G J~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Gloster, T M~~]]	+	[[Category: Davies GJ]]
-	[[Category: ~~Vasella, A~~]]	+	[[Category: Gloster TM]]
-	[[Category: ~~Zechel, D~~]]	+	[[Category: Vasella A]]
-	[[Category: ~~Carbohydrate metabolism]]~~	+	[[Category: Zechel D]]
-	~~[[Category: Cellulose degradation]]~~	+
-	~~[[Category: Family 1]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Glycoside hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Polysaccharide degradation]]~~	+
-	~~[[Category: Transition state mimic~~]]	+

OCA at 08:03, 19 January 2022

OCA — Wed, 19 Jan 2022 08:03:12 GMT

←Older revision		Revision as of 08:03, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2j79' size='340' side='right'caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='2j79' size='340' side='right'caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [~~http~~://pdbe.org/2j79 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [https://pdbe.org/2j79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [https://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:42, 15 April 2020

OCA — Wed, 15 Apr 2020 07:42:24 GMT

←Older revision		Revision as of 07:42, 15 April 2020
Line 1:		Line 1:

	==Beta-glucosidase from Thermotoga maritima in complex with galacto- hydroximolactam==		==Beta-glucosidase from Thermotoga maritima in complex with galacto- hydroximolactam==
-	<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='2j79' size='340' side='right'caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://pdbe.org/2j79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://pdbe.org/2j79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Beta-glucosidase\|Beta-glucosidase]]	+	*[[Beta-glucosidase 3D structures\|Beta-glucosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
		+	[[Category: Large Structures]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Gloster, T M]]		[[Category: Gloster, T M]]

OCA at 06:37, 11 July 2018

OCA — Wed, 11 Jul 2018 06:37:32 GMT

←Older revision		Revision as of 06:37, 11 July 2018
Line 1:		Line 1:
-	==~~BETA~~-~~GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GALACTO~~-~~HYDROXIMOLACTAM~~==	+
		+	==Beta-glucosidase from Thermotoga maritima in complex with galacto- hydroximolactam==
	<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://pdbe.org/2j79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://pdbe.org/2j79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j79 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j79_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j79_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:14, 8 February 2016

OCA — Mon, 08 Feb 2016 02:14:01 GMT

←Older revision		Revision as of 02:14, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j79 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:54, 10 September 2015

OCA — Thu, 10 Sep 2015 06:54:34 GMT

←Older revision		Revision as of 06:54, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://pdbe.org/2j79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j79" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43589]]
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
-	[[Category: Thermotoga maritima]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Gloster, T M]]		[[Category: Gloster, T M]]

OCA at 13:24, 19 January 2015

OCA — Mon, 19 Jan 2015 13:24:29 GMT

←Older revision		Revision as of 13:24, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J79 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Gloster, T M.]]	+	[[Category: Gloster, T M]]
-	[[Category: Vasella, A.]]	+	[[Category: Vasella, A]]
-	[[Category: Zechel, D.]]	+	[[Category: Zechel, D]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
	[[Category: Cellulose degradation]]		[[Category: Cellulose degradation]]

OCA at 04:30, 29 September 2014

OCA — Mon, 29 Sep 2014 04:30:38 GMT

←Older revision		Revision as of 04:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2j79.~~png~~\|~~left~~\|200px]]	+	==BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GALACTO-HYDROXIMOLACTAM==
		+	<StructureSection load='2j79' size='340' side='right' caption='[[2j79]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J79 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTL:(2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE'>GTL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]], [[2cet\|2cet]], [[2j75\|2j75]], [[2j77\|2j77]], [[2j78\|2j78]], [[2j7a\|2j7a]], [[2j7b\|2j7b]], [[2j7c\|2j7c]], [[2j7d\|2j7d]], [[2j7e\|2j7e]], [[2j7f\|2j7f]], [[2j7g\|2j7g]], [[2j7h\|2j7h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j79 RCSB], [http://www.ebi.ac.uk/pdbsum/2j79 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j79_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The inhibition of glycoside hydrolases, through transition-state mimicry, is important both as a probe of enzyme mechanism and in the continuing quest for new drugs, notably in the treatment of cancer, HIV, influenza, and diabetes. The high affinity with which these enzymes are known to bind the transition state provides a framework upon which to design potent inhibitors. Recent work [for example, Bulow, A. et al. J. Am. Chem. Soc. 2000, 122, 8567-8568; Zechel, D. L. et al. J. Am. Chem. Soc. 2003, 125, 14313-14323] has revealed quite confusing and counter-intuitive patterns of inhibition for a number of glycosidase inhibitors. Here we describe a synergistic approach for analysis of inhibitors with a single enzyme 'model system', the Thermotoga maritima family 1 beta-glucosidase, TmGH1. The pH dependence of enzyme activity and inhibition has been determined, structures of inhibitor complexes have been solved by X-ray crystallography, with data up to 1.65 A resolution, and isothermal titration calorimetry was used to establish the thermodynamic signature. This has allowed the characterization of 18 compounds, all putative transition-state mimics, in order to build an 'inhibition profile' that provides an insight into what governs binding. In contrast to our preconceptions, there is little correlation of inhibitor chemistry with the calorimetric dissection of thermodynamics. The ensemble of inhibitors shows strong enthalpy-entropy compensation, and the random distribution of similar inhibitors across the plot of DeltaH degrees a vs TDeltaS degrees a likely reflects the enormous contribution of solvation and desolvation effects on ligand binding.

-	~~{{STRUCTURE_2j79\| PDB=2j79 \| SCENE= }}~~	+	Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics.,Gloster TM, Meloncelli P, Stick RV, Zechel D, Vasella A, Davies GJ J Am Chem Soc. 2007 Feb 28;129(8):2345-54. Epub 2007 Feb 6. PMID:17279749<ref>PMID:17279749</ref>

-	~~===BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GALACTO-HYDROXIMOLACTAM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17279749}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2j79]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-glucosidase\|Beta-glucosidase]]		*[[Beta-glucosidase\|Beta-glucosidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017279749<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA at 08:33, 20 October 2012

OCA — Sat, 20 Oct 2012 08:33:33 GMT

←Older revision		Revision as of 08:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2j79]] is a 2 chain structure ~~of [[Beta-glucosidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA].	+	[[2j79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J79 OCA].

	==See Also==		==See Also==

OCA: Protected "2j79" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 19:55:04 GMT

Protected "2j79" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:55, 25 July 2012