2jbm - Revision history

OCA at 09:36, 9 May 2024

OCA — Thu, 09 May 2024 09:36:26 GMT

←Older revision		Revision as of 09:36, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2jbm' size='340' side='right'caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2jbm' size='340' side='right'caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SRT:S~~,~~R+MESO-TARTARIC+ACID'>SRT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [https://pdbe.org/2jbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [https://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [https://pdbe.org/2jbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [https://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NADC_HUMAN NADC_HUMAN] Involved in the catabolism of quinolinic acid (QA).<ref>PMID:17868694</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, H]]	+	[[Category: Liu H]]
-	[[Category: Naismith~~, J H]]~~	+	[[Category: Naismith JH]]
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Metabolism]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Pyridine nucleotide biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:06, 19 January 2022

OCA — Wed, 19 Jan 2022 08:06:22 GMT

←Older revision		Revision as of 08:06, 19 January 2022
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	<StructureSection load='2jbm' size='340' side='right'caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2jbm' size='340' side='right'caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [~~http~~://pdbe.org/2jbm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [https://pdbe.org/2jbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [https://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:46, 15 April 2020

OCA — Wed, 15 Apr 2020 07:46:30 GMT

←Older revision		Revision as of 07:46, 15 April 2020
Line 1:		Line 1:

	==QPRTASE STRUCTURE FROM HUMAN==		==QPRTASE STRUCTURE FROM HUMAN==
-	<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2jbm' size='340' side='right'caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://pdbe.org/2jbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://pdbe.org/2jbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liu, H]]		[[Category: Liu, H]]
	[[Category: Naismith, J H]]		[[Category: Naismith, J H]]

OCA at 06:53, 11 July 2018

OCA — Wed, 11 Jul 2018 06:53:11 GMT

←Older revision		Revision as of 06:53, 11 July 2018
Line 1:		Line 1:
		+
	==QPRTASE STRUCTURE FROM HUMAN==		==QPRTASE STRUCTURE FROM HUMAN==
	<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://pdbe.org/2jbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://pdbe.org/2jbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 40:		Line 41:
	[[Category: Metabolism]]		[[Category: Metabolism]]
	[[Category: Nad]]		[[Category: Nad]]
		+	[[Category: Polymorphism]]
	[[Category: Pyridine nucleotide biosynthesis]]		[[Category: Pyridine nucleotide biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:44, 11 September 2015

OCA — Fri, 11 Sep 2015 10:44:25 GMT

←Older revision		Revision as of 10:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://pdbe.org/2jbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jbm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Liu, H]]		[[Category: Liu, H]]
	[[Category: Naismith, J H]]		[[Category: Naismith, J H]]

OCA at 13:44, 19 January 2015

OCA — Mon, 19 Jan 2015 13:44:41 GMT

←Older revision		Revision as of 13:44, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Liu, H.]]	+	[[Category: Liu, H]]
-	[[Category: Naismith, J H.]]	+	[[Category: Naismith, J H]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]

OCA at 08:01, 30 September 2014

OCA — Tue, 30 Sep 2014 08:01:28 GMT

←Older revision		Revision as of 08:01, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jbm.~~png\|left~~\|200px]]	+	==QPRTASE STRUCTURE FROM HUMAN==
		+	<StructureSection load='2jbm' size='340' side='right' caption='[[2jbm]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbm RCSB], [http://www.ebi.ac.uk/pdbsum/2jbm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human quinolinate phosphoribosyltransferase (EC 2.4.2.19) (hQPRTase) is a member of the type II phosphoribosyltransferase family involved in the catabolism of quinolinic acid (QA). It catalyses the formation of nicotinic acid mononucleotide from quinolinic acid, which involves a phosphoribosyl transfer reaction followed by decarboxylation. hQPRTase has been implicated in a number of neurological conditions and in order to study it further, we have carried out structural and kinetic studies on recombinant hQPRTase. The structure of the fully active enzyme overexpressed in Escherichia coli was solved using multiwavelength methods to a resolution of 2.0 A. hQPRTase has a alpha/beta barrel fold sharing a similar overall structure with the bacterial QPRTases. The active site of hQPRTase is located at an alpha/beta open sandwich structure that serves as a cup for the alpha/beta barrel of the adjacent subunit with a QA binding site consisting of three arginine residues (R102, R138 and R161) and two lysine residues (K139 and K171). Mutation of these residues affected substrate binding or abolished the enzymatic activity. The kinetics of the human enzyme are different to the bacterial enzymes studied, hQPRTase is inhibited competitively and non-competitively by one of its substrates, 5-phosphoribosylpyrophosphate (PRPP). The human enzyme adopts a hexameric arrangement, which places the active sites in close proximity to each other.

-	~~{{STRUCTURE_2jbm\| PDB=2jbm \| SCENE= }}~~	+	Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens.,Liu H, Woznica K, Catton G, Crawford A, Botting N, Naismith JH J Mol Biol. 2007 Oct 26;373(3):755-63. Epub 2007 Aug 24. PMID:17868694<ref>PMID:17868694</ref>

-	~~===QPRTASE STRUCTURE FROM HUMAN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17868694}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jbm]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017868694<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Liu, H.]]		[[Category: Liu, H.]]

OCA: Protected "2jbm" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:05:34 GMT

Protected "2jbm" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:05, 7 January 2013

OCA at 18:05, 7 January 2013

OCA — Mon, 07 Jan 2013 18:05:30 GMT

←Older revision		Revision as of 18:05, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jbm.png\|left\|200px]]		[[Image:2jbm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jbm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jbm\| PDB=2jbm \| SCENE= }}		{{STRUCTURE_2jbm\| PDB=2jbm \| SCENE= }}

	===QPRTASE STRUCTURE FROM HUMAN===		===QPRTASE STRUCTURE FROM HUMAN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17868694}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17868694 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17868694}}		{{ABSTRACT_PUBMED_17868694}}

	==About this Structure==		==About this Structure==
-	~~2JBM~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA].	+	[[2jbm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17868694~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017868694</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Liu, H.]]		[[Category: Liu, H.]]
Line 31:		Line 22:
	[[Category: Metabolism]]		[[Category: Metabolism]]
	[[Category: Nad]]		[[Category: Nad]]
-	[[Category: Polymorphism]]
	[[Category: Pyridine nucleotide biosynthesis]]		[[Category: Pyridine nucleotide biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:13:36 2009''

OCA at 18:13, 17 February 2009

OCA — Tue, 17 Feb 2009 18:13:37 GMT

←Older revision		Revision as of 18:13, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JBM is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA].	+	2JBM is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBM OCA].

	==Reference==		==Reference==
-	Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens., Liu H, Woznica K, Catton G, Crawford A, Botting N, Naismith JH, J Mol Biol. 2007 Oct 26;373(3):755-63. Epub 2007 Aug 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17868694 17868694]~~	+	<ref group="xtra">PMID:17868694</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Liu, H.]]		[[Category: Liu, H.]]
	[[Category: Naismith, J H.]]		[[Category: Naismith, J H.]]
Line 36:		Line 35:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:05:~~14 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:13:36 2009''