2jbx - Revision history

OCA at 06:41, 1 May 2024

OCA — Wed, 01 May 2024 06:41:51 GMT

←Older revision		Revision as of 06:41, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2jby\|2jby]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [https://pdbe.org/2jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [https://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [https://pdbe.org/2jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [https://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q85295_9POXV Q85295_9POXV]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbx ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.
-
-	A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.,Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM Mol Cell. 2007 Mar 23;25(6):933-42. PMID:17386268<ref>PMID:17386268</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2jbx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]		*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
-	[[Category: Colman~~, P M]]~~	+	[[Category: Colman PM]]
-	~~[[Category: Delft, M F.Van~~]]	+	[[Category: Fairlie WD]]
-	[[Category: Fairlie~~, W D~~]]	+	[[Category: Gulbis JM]]
-	[[Category: Gulbis~~, J M~~]]	+	[[Category: Huang DCS]]
-	[[Category: Huang~~, D C.S~~]]	+	[[Category: Kvansakul M]]
-	[[Category: Kvansakul, M]]	+	[[Category: Lee EF]]
-	[[Category: Lee~~, E F~~]]	+	[[Category: Van Delft MF]]
-	[[Category: ~~Apoptosis]]~~	+
-	~~[[Category: Bcl-2 family~~]]	+

OCA at 08:06, 19 January 2022

OCA — Wed, 19 Jan 2022 08:06:35 GMT

←Older revision		Revision as of 08:06, 19 January 2022
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	<StructureSection load='2jbx' size='340' side='right'caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='2jbx' size='340' side='right'caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jby\|2jby]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [~~http~~://pdbe.org/2jbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [https://pdbe.org/2jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [https://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:46, 15 April 2020

OCA — Wed, 15 Apr 2020 07:46:44 GMT

←Older revision		Revision as of 07:46, 15 April 2020
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	==Crystal Structure of the myxoma virus anti-apoptotic protein M11L==		==Crystal Structure of the myxoma virus anti-apoptotic protein M11L==
-	<StructureSection load='2jbx' size='340' side='right' caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='2jbx' size='340' side='right'caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://pdbe.org/2jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://pdbe.org/2jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]	+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]

OCA at 06:46, 11 July 2018

OCA — Wed, 11 Jul 2018 06:46:25 GMT

←Older revision		Revision as of 06:46, 11 July 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI~~-~~APOPTOTIC PROTEIN~~ M11L==	+
		+	==Crystal Structure of the myxoma virus anti-apoptotic protein M11L==
	<StructureSection load='2jbx' size='340' side='right' caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='2jbx' size='340' side='right' caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://pdbe.org/2jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://pdbe.org/2jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[~~Bcl~~-2\|~~Bcl~~-2]]	+	*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:15, 8 February 2016

OCA — Mon, 08 Feb 2016 11:15:40 GMT

←Older revision		Revision as of 11:15, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:00, 10 September 2015

OCA — Thu, 10 Sep 2015 11:00:42 GMT

←Older revision		Revision as of 11:00, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://pdbe.org/2jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jbx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:21, 19 January 2015

OCA — Mon, 19 Jan 2015 15:21:23 GMT

←Older revision		Revision as of 15:21, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
-	[[Category: Colman, P M.]]	+	[[Category: Colman, P M]]
-	[[Category: Delft, M F.Van.]]	+	[[Category: Delft, M F.Van]]
-	[[Category: Fairlie, W D.]]	+	[[Category: Fairlie, W D]]
-	[[Category: Gulbis, J M.]]	+	[[Category: Gulbis, J M]]
-	[[Category: Huang, D C.S.]]	+	[[Category: Huang, D C.S]]
-	[[Category: Kvansakul, M.]]	+	[[Category: Kvansakul, M]]
-	[[Category: Lee, E F.]]	+	[[Category: Lee, E F]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bcl-2 family]]		[[Category: Bcl-2 family]]
-	[[Category: Myxoma virus]]

OCA at 08:40, 30 September 2014

OCA — Tue, 30 Sep 2014 08:40:41 GMT

←Older revision		Revision as of 08:40, 30 September 2014
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-	[[~~Image:~~2jbx.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L==
		+	<StructureSection load='2jbx' size='340' side='right' caption='[[2jbx]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jby\|2jby]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [http://www.ebi.ac.uk/pdbsum/2jbx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.

-	~~{{STRUCTURE_2jbx\| PDB=2jbx \| SCENE= }}~~	+	A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.,Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM Mol Cell. 2007 Mar 23;25(6):933-42. PMID:17386268<ref>PMID:17386268</ref>

-	~~===CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17386268}}~~	+	==See Also==
-		+	*[[Bcl-2\|Bcl-2]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2jbx]] is a~~ 2 ~~chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca~~-~~bin/ocashort?id=2JBX OCA~~].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017386268<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
	[[Category: Colman, P M.]]		[[Category: Colman, P M.]]

OCA: Protected "2jbx" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:03:10 GMT

Protected "2jbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:03, 7 January 2013

OCA at 11:03, 7 January 2013

OCA — Mon, 07 Jan 2013 11:03:08 GMT

←Older revision		Revision as of 11:03, 7 January 2013
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-	{{Seed}}
	[[Image:2jbx.png\|left\|200px]]		[[Image:2jbx.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2jbx\| PDB=2jbx \| SCENE= }}		{{STRUCTURE_2jbx\| PDB=2jbx \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L===		===CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17386268}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17386268 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17386268}}		{{ABSTRACT_PUBMED_17386268}}

	==About this Structure==		==About this Structure==
-	~~2JBX~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA].	+	[[2jbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17386268~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017386268</ref><references group="xtra"/>
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
	[[Category: Colman, P M.]]		[[Category: Colman, P M.]]
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	[[Category: Bcl-2 family]]		[[Category: Bcl-2 family]]
	[[Category: Myxoma virus]]		[[Category: Myxoma virus]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:35:05 2009''