2jdq - Revision history

OCA at 14:44, 13 December 2023

OCA — Wed, 13 Dec 2023 14:44:20 GMT

←Older revision		Revision as of 14:44, 13 December 2023
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	<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~9infa 9infa~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2gmo~~\|~~2gmo~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [https://pdbe.org/2jdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [https://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [https://pdbe.org/2jdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [https://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IMA5_HUMAN IMA5_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baudin, F]]	+	[[Category: Baudin F]]
-	[[Category: Boulo, S]]	+	[[Category: Boulo S]]
-	[[Category: Cusack, S]]	+	[[Category: Cusack S]]
-	[[Category: Guilligay, D]]	+	[[Category: Guilligay D]]
-	[[Category: Hart~~, D J~~]]	+	[[Category: Hart DJ]]
-	[[Category: Mas, P]]	+	[[Category: Mas P]]
-	[[Category: Ruigrok~~, R W.H~~]]	+	[[Category: Ruigrok RWH]]
-	[[Category: Tarendeau, F]]	+	[[Category: Tarendeau F]]
-	~~[[Category: Armadillo repeat]]~~	+
-	~~[[Category: Bipartite nuclear localisation signal]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Human importin alpha5]]~~	+
-	~~[[Category: Influenza a virus rna-dependent rna polymerase]]~~	+
-	~~[[Category: Nuclear import adapter]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Pb2 subunit]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 20:44, 20 October 2021

OCA — Wed, 20 Oct 2021 20:44:55 GMT

←Older revision		Revision as of 20:44, 20 October 2021
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	<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9infa 9infa] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/9infa 9infa] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gmo\|2gmo]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [~~http~~://pdbe.org/2jdq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [https://pdbe.org/2jdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [https://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:37, 10 October 2019

OCA — Thu, 10 Oct 2019 05:37:23 GMT

←Older revision		Revision as of 05:37, 10 October 2019
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	==C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5==		==C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5==
-	<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2jdq' size='340' side='right'caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Importin\|Importin]]	+	*[[Importin 3D structures\|Importin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baudin, F]]		[[Category: Baudin, F]]
	[[Category: Boulo, S]]		[[Category: Boulo, S]]

OCA at 06:43, 11 July 2018

OCA — Wed, 11 Jul 2018 06:43:09 GMT

←Older revision		Revision as of 06:43, 11 July 2018
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-	==C-~~TERMINAL DOMAIN OF INFLUENZA~~ A ~~VIRUS POLYMERASE~~ PB2 ~~SUBUNIT IN COMPLEX WITH HUMAN IMPORTIN ALPHA5~~==	+
		+	==C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5==
	<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://pdbe.org/2jdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://pdbe.org/2jdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jdq ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/PB2_I75A3 PB2_I75A3]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/2jdq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/2jdq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:43, 9 February 2016

OCA — Tue, 09 Feb 2016 16:43:58 GMT

←Older revision		Revision as of 16:43, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jdq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:11, 11 September 2015

OCA — Fri, 11 Sep 2015 00:11:10 GMT

←Older revision		Revision as of 00:11, 11 September 2015
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	<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://pdbe.org/2jdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PB2_I75A3 PB2_I75A3]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jdq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Human]]
-	~~[[Category: Influenza a virus~~]]	+
	[[Category: Baudin, F]]		[[Category: Baudin, F]]
	[[Category: Boulo, S]]		[[Category: Boulo, S]]

OCA at 16:34, 19 January 2015

OCA — Mon, 19 Jan 2015 16:34:12 GMT

←Older revision		Revision as of 16:34, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Baudin, F.]]	+	[[Category: Baudin, F]]
-	[[Category: Boulo, S.]]	+	[[Category: Boulo, S]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Guilligay, D.]]	+	[[Category: Guilligay, D]]
-	[[Category: Hart, D J.]]	+	[[Category: Hart, D J]]
-	[[Category: Mas, P.]]	+	[[Category: Mas, P]]
-	[[Category: Ruigrok, R W.H.]]	+	[[Category: Ruigrok, R W.H]]
-	[[Category: Tarendeau, F.]]	+	[[Category: Tarendeau, F]]
	[[Category: Armadillo repeat]]		[[Category: Armadillo repeat]]
	[[Category: Bipartite nuclear localisation signal]]		[[Category: Bipartite nuclear localisation signal]]

OCA at 09:20, 3 October 2014

OCA — Fri, 03 Oct 2014 09:20:56 GMT

←Older revision		Revision as of 09:20, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. <br>	+	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JDQ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>		</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>
	<table>		<table>
Line 23:		Line 22:
	Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit.,Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ Nat Struct Mol Biol. 2007 Mar;14(3):229-33. Epub 2007 Feb 25. PMID:17310249<ref>PMID:17310249</ref>		Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit.,Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ Nat Struct Mol Biol. 2007 Mar;14(3):229-33. Epub 2007 Feb 25. PMID:17310249<ref>PMID:17310249</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Importin\|Importin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:53, 1 May 2014

OCA — Thu, 01 May 2014 09:53:29 GMT

←Older revision		Revision as of 09:53, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jdq' size='340' side='right' caption='[[2jdq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. <br>	+	<table><tr><td colspan='2'>[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. <br>
-	<b>[[Related_structure\|Related:]]</b> [[2gmo\|2gmo]]<br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gmo\|2gmo]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 16:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	The trimeric influenza virus polymerase, comprising subunits PA, PB1 and PB2, is responsible for transcription and replication of the segmented viral RNA genome. Using a novel library-based screening technique called expression of soluble proteins by random incremental truncation (ESPRIT), we identified an independently folded C-terminal domain from PB2 and determined its solution structure by NMR. Using green fluorescent protein fusions, we show that both the domain and the full-length PB2 subunit are efficiently imported into the nucleus dependent on a previously overlooked bipartite nuclear localization sequence (NLS). The crystal structure of the domain complexed with human importin alpha5 shows how the last 20 residues unfold to permit binding to the import factor. The domain contains three surface residues implicated in adaptation from avian to mammalian hosts. One of these tethers the NLS-containing peptide to the core of the domain in the unbound state.		The trimeric influenza virus polymerase, comprising subunits PA, PB1 and PB2, is responsible for transcription and replication of the segmented viral RNA genome. Using a novel library-based screening technique called expression of soluble proteins by random incremental truncation (ESPRIT), we identified an independently folded C-terminal domain from PB2 and determined its solution structure by NMR. Using green fluorescent protein fusions, we show that both the domain and the full-length PB2 subunit are efficiently imported into the nucleus dependent on a previously overlooked bipartite nuclear localization sequence (NLS). The crystal structure of the domain complexed with human importin alpha5 shows how the last 20 residues unfold to permit binding to the import factor. The domain contains three surface residues implicated in adaptation from avian to mammalian hosts. One of these tethers the NLS-containing peptide to the core of the domain in the unbound state.
Line 22:		Line 24:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:18, 30 April 2014

OCA — Wed, 30 Apr 2014 10:18:07 GMT

←Older revision		Revision as of 10:18, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. <br>		[[2jdq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDQ OCA]. <br>
-	<b>Related:</b> [[2gmo\|2gmo]]<br>	+	<b>[[Related_structure\|Related:]]</b> [[2gmo\|2gmo]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jdq RCSB], [http://www.ebi.ac.uk/pdbsum/2jdq PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]