2jeu - Revision history

OCA at 14:45, 13 December 2023

OCA — Wed, 13 Dec 2023 14:45:41 GMT

←Older revision		Revision as of 14:45, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jeu' size='340' side='right'caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jeu' size='340' side='right'caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deltapapillomavirus_4 Deltapapillomavirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1dbd\|1dbd]]~~, [[~~1jjh~~\|~~1jjh~~]]~~, [[2bop\|2bop]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [https://pdbe.org/2jeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [https://www.ebi.ac.uk/pdbsum/2jeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [https://pdbe.org/2jeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [https://www.ebi.ac.uk/pdbsum/2jeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.	+	[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Deltapapillomavirus 4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antson~~, A A~~]]	+	[[Category: Antson AA]]
-	[[Category: Ortiz-Lombardia, M]]	+	[[Category: Ortiz-Lombardia M]]
-	[[Category: Sanders~~, C M~~]]	+	[[Category: Sanders CM]]
-	[[Category: Seavers~~, P R~~]]	+	[[Category: Seavers PR]]
-	[[Category: Sizov, D]]	+	[[Category: Sizov D]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Bovine papillomavirus]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: E1]]~~	+
-	~~[[Category: E2]]~~	+
-	~~[[Category: Early protein]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Oxidation]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Redox control]]~~	+
-	~~[[Category: Replication initiation]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Viral transcription factor~~]]	+

OCA at 11:26, 31 March 2021

OCA — Wed, 31 Mar 2021 11:26:32 GMT

←Older revision		Revision as of 11:26, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='2jeu' size='340' side='right'caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jeu' size='340' side='right'caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [~~http~~://pdbe.org/2jeu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jeu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [https://pdbe.org/2jeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [https://www.ebi.ac.uk/pdbsum/2jeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.	+	[[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2jeu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2jeu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Regulatory protein E2\|Regulatory protein E2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:06, 10 May 2019

OCA — Fri, 10 May 2019 12:06:49 GMT

←Older revision		Revision as of 12:06, 10 May 2019
Line 1:		Line 1:

	==Transcription activator structure reveals redox control of a replication initiation reaction==		==Transcription activator structure reveals redox control of a replication initiation reaction==
-	<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2jeu' size='340' side='right'caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Ortiz-Lombardia, M]]		[[Category: Ortiz-Lombardia, M]]

OCA at 06:45, 11 July 2018

OCA — Wed, 11 Jul 2018 06:45:48 GMT

←Older revision		Revision as of 06:45, 11 July 2018
Line 1:		Line 1:
-	==~~TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION~~==	+
		+	==Transcription activator structure reveals redox control of a replication initiation reaction==
	<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Bpv-1 Bpv-1]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://pdbe.org/2jeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://pdbe.org/2jeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jeu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jeu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jeu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bpv-1]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Ortiz-Lombardia, M]]		[[Category: Ortiz-Lombardia, M]]

OCA at 07:41, 11 September 2015

OCA — Fri, 11 Sep 2015 07:41:14 GMT

←Older revision		Revision as of 07:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bovine_papillomavirus_type_1 Bovine papillomavirus type~~ 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpv-1 Bpv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://pdbe.org/2jeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jeu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovine papillomavirus type~~ 1]]	+	[[Category: Bpv-1]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Ortiz-Lombardia, M]]		[[Category: Ortiz-Lombardia, M]]

OCA at 13:22, 25 December 2014

OCA — Thu, 25 Dec 2014 13:22:49 GMT

←Older revision		Revision as of 13:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Bovine papillomavirus type 1]]		[[Category: Bovine papillomavirus type 1]]
-	[[Category: Antson, A A.]]	+	[[Category: Antson, A A]]
-	[[Category: Ortiz-Lombardia, M.]]	+	[[Category: Ortiz-Lombardia, M]]
-	[[Category: Sanders, C M.]]	+	[[Category: Sanders, C M]]
-	[[Category: Seavers, P R.]]	+	[[Category: Seavers, P R]]
-	[[Category: Sizov, D.]]	+	[[Category: Sizov, D]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Bovine papillomavirus]]		[[Category: Bovine papillomavirus]]

OCA at 07:54, 30 September 2014

OCA — Tue, 30 Sep 2014 07:54:37 GMT

←Older revision		Revision as of 07:54, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jeu.~~png~~\|~~left~~\|200px]]	+	==TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION==
		+	<StructureSection load='2jeu' size='340' side='right' caption='[[2jeu]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dbd\|1dbd]], [[1jjh\|1jjh]], [[2bop\|2bop]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jeu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Redox changes are one of the factors that influence cell-cycle progression and that control the processes of cellular proliferation, differentiation, senescence and apoptosis. Proteins regulated through redox-sensitive cysteines have been characterized but specific 'sulphydryl switches' in replication proteins remain to be identified. In bovine papillomavirus type-1, DNA replication begins when the viral transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (ori). Here we show that a novel dimerization interface in the E2 transcription activation domain is stabilized by a disulphide bond. Oxidative cross-linking via Cys57 sequesters the interaction surface between E1 and E2, preventing pre-initiation and replication initiation complex formation. Our data demonstrate that as well as a mechanism for regulating DNA binding, redox reactions can control replication by modulating the tertiary structure of critical protein factors using a specific redox sensor.

-	~~{{STRUCTURE_2jeu\| PDB=2jeu \| SCENE= }}~~	+	Transcription activator structure reveals redox control of a replication initiation reaction.,Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:17478495<ref>PMID:17478495</ref>

-	~~===TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17478495}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jeu]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017478495<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bovine papillomavirus type 1]]		[[Category: Bovine papillomavirus type 1]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A.]]

OCA: Protected "2jeu" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:02:04 GMT

Protected "2jeu" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:02, 7 January 2013

OCA at 13:02, 7 January 2013

OCA — Mon, 07 Jan 2013 13:02:01 GMT

←Older revision		Revision as of 13:02, 7 January 2013
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-	{{Seed}}
	[[Image:2jeu.png\|left\|200px]]		[[Image:2jeu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jeu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2jeu\| PDB=2jeu \| SCENE= }}		{{STRUCTURE_2jeu\| PDB=2jeu \| SCENE= }}

	===TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION===		===TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17478495}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17478495 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17478495}}		{{ABSTRACT_PUBMED_17478495}}

	==About this Structure==		==About this Structure==
-	~~2JEU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA].	+	[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17478495~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017478495</ref><references group="xtra"/>
	[[Category: Bovine papillomavirus type 1]]		[[Category: Bovine papillomavirus type 1]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A.]]
Line 46:		Line 34:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Viral transcription factor]]		[[Category: Viral transcription factor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:17:51 2009''

OCA at 15:17, 17 February 2009

OCA — Tue, 17 Feb 2009 15:17:52 GMT

←Older revision		Revision as of 15:17, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JEU is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA].	+	2JEU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA].

	==Reference==		==Reference==
-	Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17478495 17478495]~~	+	<ref group="xtra">PMID:17478495</ref><references group="xtra"/>
	[[Category: Bovine papillomavirus type 1]]		[[Category: Bovine papillomavirus type 1]]
-	[[Category: Single protein]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A.]]
	[[Category: Ortiz-Lombardia, M.]]		[[Category: Ortiz-Lombardia, M.]]
Line 48:		Line 47:
	[[Category: Viral transcription factor]]		[[Category: Viral transcription factor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 00~~:10:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:17:51 2009''