2jew - Revision history

OCA at 14:45, 13 December 2023

OCA — Wed, 13 Dec 2023 14:45:44 GMT

←Older revision		Revision as of 14:45, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=720:(2S)-5-AMINO-2~~-[(1~~-PROPYL-1H-IMIDAZOL-~~4~~-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[1nsa\|1nsa~~]~~], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [https://pdbe.org/2jew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [https://www.ebi.ac.uk/pdbsum/2jew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jew ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [https://pdbe.org/2jew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [https://www.ebi.ac.uk/pdbsum/2jew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jew ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBPB1_PIG CBPB1_PIG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carboxypeptidase B]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Brown~~, D G~~]]	+	[[Category: Brown DG]]
-	[[Category: Moore~~, R S]]~~	+	[[Category: Moore RS]]
-	~~[[Category: Carboxypeptidase]]~~	+
-	~~[[Category: Carboxypeptidase b]]~~	+
-	~~[[Category: Direct metal-binding]]~~	+
-	~~[[Category: Exopeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 20:44, 20 October 2021

OCA — Wed, 20 Oct 2021 20:44:56 GMT

←Older revision		Revision as of 20:44, 20 October 2021
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	<StructureSection load='2jew' size='340' side='right'caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2jew' size='340' side='right'caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [~~http~~://pdbe.org/2jew PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jew PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [https://pdbe.org/2jew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [https://www.ebi.ac.uk/pdbsum/2jew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:06, 11 December 2019

OCA — Wed, 11 Dec 2019 19:06:29 GMT

←Older revision		Revision as of 19:06, 11 December 2019
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	==Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB==		==Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB==
-	<StructureSection load='2jew' size='340' side='right' caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='2jew' size='340' side='right'caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEW FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Brown, D G]]		[[Category: Brown, D G]]

OCA at 06:32, 20 December 2017

OCA — Wed, 20 Dec 2017 06:32:08 GMT

←Older revision		Revision as of 06:32, 20 December 2017
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-	==~~CRYSTAL STRUCTURE OF~~ ((2S)-5-~~AMINO~~-2-((1-N-~~PROPYL~~-1H-~~IMIDAZOL~~-4-YL)~~METHYL~~)~~PENTANOIC ACID~~) UK396,082 ~~A TAFIA INHIBITOR~~, ~~BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASEB~~==	+
		+	==Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB==
	<StructureSection load='2jew' size='340' side='right' caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2jew' size='340' side='right' caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://pdbe.org/2jew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://pdbe.org/2jew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jew_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jew_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2jew" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2jew" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Carboxypeptidase\|Carboxypeptidase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]
	[[Category: Protease]]		[[Category: Protease]]
		+	[[Category: Zinc]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 12:31, 8 February 2016

OCA — Mon, 08 Feb 2016 12:31:51 GMT

←Older revision		Revision as of 12:31, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jew ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:36, 10 September 2015

OCA — Thu, 10 Sep 2015 11:36:13 GMT

←Older revision		Revision as of 11:36, 10 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://pdbe.org/2jew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jew" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:13, 19 January 2015

OCA — Mon, 19 Jan 2015 16:13:25 GMT

←Older revision		Revision as of 16:13, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Brown, D G.]]	+	[[Category: Brown, D G]]
-	[[Category: Moore, R S.]]	+	[[Category: Moore, R S]]
	[[Category: Carboxypeptidase]]		[[Category: Carboxypeptidase]]
	[[Category: Carboxypeptidase b]]		[[Category: Carboxypeptidase b]]

OCA at 03:20, 29 September 2014

OCA — Mon, 29 Sep 2014 03:20:45 GMT

←Older revision		Revision as of 03:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jew.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF ((2S)-5-AMINO-2-((1-N-PROPYL-1H-IMIDAZOL-4-YL)METHYL)PENTANOIC ACID) UK396,082 A TAFIA INHIBITOR, BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASEB==
		+	<StructureSection load='2jew' size='340' side='right' caption='[[2jew]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=720:(2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC+ACID'>720</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nsa\|1nsa]], [[1pba\|1pba]], [[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jew RCSB], [http://www.ebi.ac.uk/pdbsum/2jew PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jew_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thrombin-activatable fibrinolysis inhibitor (TAFI) has emerged as a key link between the coagulation and fibrinolysis cascades and represents a promising new target for the treatment of thrombosis. A novel series of imidazolepropionic acids has been designed that exhibit high potency against activated TAFI (TAFIa) and excellent selectivity over plasma carboxypeptidase N (CPN). Structure activity relationships suggest that the imidazole moiety plays a key role in binding to the catalytic zinc of TAFIa, and this has been supported by crystallographic studies using porcine pancreatic carboxypeptidase B as a surrogate for TAFIa. The SAR program led to the identification of 21 (TAFIa Ki = 10 nM, selectivity TAFIa/CPN > 1000) as a candidate for clinical development. Compound 21 exhibited antithrombotic efficacy in a rabbit model of venous thrombosis, yet had no effect on surgical bleeding in the rabbit. In addition, 21 exhibited an excellent preclinical and clinical pharmacokinetic profile, characterized by paracellular absorption, low clearance, and a low volume of distribution, fully consistent with its physicochemical properties of low molecular weight (MW = 239) and high hydrophilicity (log D = -2.8). These data indicate 21 (UK-396,082) has potential as a novel TAFIa inhibitor for the treatment of thrombosis and other fibrin-dependent diseases in humans.

-	~~{{STRUCTURE_2jew\| PDB=2jew \| SCENE= }}~~	+	Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.,Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K, Evans K, Gray AJ, Holland SJ, Feeder N, Moore RS, Brown DG J Med Chem. 2007 Nov 29;50(24):6095-103. Epub 2007 Nov 9. PMID:17990866<ref>PMID:17990866</ref>

-	~~===CRYSTAL STRUCTURE OF ((2S)-5-AMINO-2-((1-N-PROPYL-1H-IMIDAZOL-4-YL)METHYL)PENTANOIC ACID) UK396~~,~~082 A TAFIA INHIBITOR, BOUND TO ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASEB===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17990866}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jew]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA].~~	+

	==See Also==		==See Also==
	*[[Carboxypeptidase\|Carboxypeptidase]]		*[[Carboxypeptidase\|Carboxypeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017990866<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 10:08, 20 October 2012

OCA — Sat, 20 Oct 2012 10:08:42 GMT

←Older revision		Revision as of 10:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jew]] is a 1 chain structure ~~of [[Carboxypeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA].	+	[[2jew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEW OCA].

	==See Also==		==See Also==

OCA: Protected "2jew" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 01:07:44 GMT

Protected "2jew" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:07, 26 July 2012