2jgf - Revision history

OCA at 14:47, 13 December 2023

OCA — Wed, 13 Dec 2023 14:47:25 GMT

←Older revision		Revision as of 14:47, 13 December 2023
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	<StructureSection load='2jgf' size='340' side='right'caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2jgf' size='340' side='right'caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</div></td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [https://pdbe.org/2jgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [https://www.ebi.ac.uk/pdbsum/2jgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [https://pdbe.org/2jgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [https://www.ebi.ac.uk/pdbsum/2jgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Ekstrom, F]]	+	[[Category: Ekstrom F]]
-	[[Category: Hornberg, A]]	+	[[Category: Hornberg A]]
-	[[Category: Tunemalm, A K]]	+	[[Category: Tunemalm A-K]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Fenamipho]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Neurotransmitter degradation]]~~	+
-	~~[[Category: Serine esterase]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 11:26, 31 March 2021

OCA — Wed, 31 Mar 2021 11:26:46 GMT

OCA at 07:44, 21 May 2019

OCA — Tue, 21 May 2019 07:44:48 GMT

←Older revision		Revision as of 07:44, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos==		==Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos==
-	<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2jgf' size='340' side='right'caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
Line 34:		Line 34:
	==See Also==		==See Also==
	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom, F]]

OCA at 07:23, 17 January 2018

OCA — Wed, 17 Jan 2018 07:23:44 GMT

←Older revision		Revision as of 07:23, 17 January 2018
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-	==~~CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON~~-~~AGED FENAMIPHOS~~==	+
		+	==Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos==
	<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://pdbe.org/2jgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://pdbe.org/2jgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Acetylcholinesterase\|Acetylcholinesterase]]	+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Hornberg, A]]		[[Category: Hornberg, A]]
	[[Category: Tunemalm, A K]]		[[Category: Tunemalm, A K]]
		+	[[Category: Alternative splicing]]
	[[Category: Fenamipho]]		[[Category: Fenamipho]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 11:32, 11 September 2015

OCA — Fri, 11 Sep 2015 11:32:48 GMT

←Older revision		Revision as of 11:32, 11 September 2015
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	<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://pdbe.org/2jgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jgf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom, F]]
	[[Category: Hornberg, A]]		[[Category: Hornberg, A]]

OCA at 15:53, 25 December 2014

OCA — Thu, 25 Dec 2014 15:53:57 GMT

←Older revision		Revision as of 15:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ekstrom, F.]]	+	[[Category: Ekstrom, F]]
-	[[Category: Hornberg, A.]]	+	[[Category: Hornberg, A]]
-	[[Category: Tunemalm, A K~~.]]~~	+	[[Category: Tunemalm, A K]]
-	~~[[Category: Acetylcholinesterase~~]]	+
	[[Category: Fenamipho]]		[[Category: Fenamipho]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 03:06, 29 September 2014

OCA — Mon, 29 Sep 2014 03:06:25 GMT

←Older revision		Revision as of 03:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jgf.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON-AGED FENAMIPHOS==
		+	<StructureSection load='2jgf' size='340' side='right' caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [http://www.ebi.ac.uk/pdbsum/2jgf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203 residue. The formed AChE-OP conjugate subsequently undergoes an elimination reaction, termed aging, that results in an enzyme completely resistant to oxime-mediated reactivation by medical antidotes. In this study, we present crystal structures of the non-aged and aged complexes between Mus musculus AChE (mAChE) and the nerve agents sarin, VX, and diisopropyl fluorophosphate (DFP) and the OP-based insecticides methamidophos (MeP) and fenamiphos (FeP). Non-aged conjugates of MeP, sarin, and FeP and aged conjugates of MeP, sarin, and VX are very similar to the noninhibited apo conformation of AChE. A minor structural change in the side chain of His447 is observed in the non-aged conjugate of VX. In contrast, an extensive rearrangement of the acyl loop region (residues 287-299) is observed in the non-aged structure of DFP and in the aged structures of DFP and FeP. In the case of FeP, the relatively large substituents of the phosphorus atom are reorganized during aging, providing a structural support of an aging reaction that proceeds through a nucleophilic attack on the phosphorus atom. The FeP aging rate constant is 14 times lower than the corresponding constant for the structurally related OP insecticide MeP, suggesting that tight steric constraints of the acyl pocket loop preclude the formation of a trigonal bipyramidal intermediate.

-	~~{{STRUCTURE_2jgf\| PDB=2jgf \| SCENE= }}~~	+	Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state.,Hornberg A, Tunemalm AK, Ekstrom F Biochemistry. 2007 Apr 24;46(16):4815-25. Epub 2007 Apr 3. PMID:17402711<ref>PMID:17402711</ref>

-	~~===CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON-AGED FENAMIPHOS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17402711}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jgf]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017402711<~~/~~ref~~><~~ref group="xtra">PMID:017020880</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 18:34, 20 October 2012

OCA — Sat, 20 Oct 2012 18:34:54 GMT

←Older revision		Revision as of 18:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jgf]] is a 2 chain structure ~~of [[Acetylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA].	+	[[2jgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA].

	==See Also==		==See Also==

OCA at 04:32, 27 July 2012

OCA — Fri, 27 Jul 2012 04:32:08 GMT

←Older revision		Revision as of 04:32, 27 July 2012
Line 1:		Line 1:
	[[Image:2jgf.png\|left\|200px]]		[[Image:2jgf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jgf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jgf\| PDB=2jgf \| SCENE= }}		{{STRUCTURE_2jgf\| PDB=2jgf \| SCENE= }}

	===CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON-AGED FENAMIPHOS===		===CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY NON-AGED FENAMIPHOS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17402711}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17402711 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17402711}}		{{ABSTRACT_PUBMED_17402711}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase]]	+	*[[Acetylcholinesterase\|Acetylcholinesterase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17402711~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017402711</ref><ref group="xtra">PMID:017020880</ref><references group="xtra"/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 32:		Line 21:
	[[Category: Tunemalm, A K.]]		[[Category: Tunemalm, A K.]]
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: Alternative splicing]]
	[[Category: Fenamipho]]		[[Category: Fenamipho]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA: Protected "2jgf" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 20:23:09 GMT

Protected "2jgf" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:23, 26 December 2010

←Older revision		Revision as of 11:26, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='2jgf' size='340' side='right'caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2jgf' size='340' side='right'caption='[[2jgf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXE:O-{(S)-ETHOXY[(1-METHYLETHYL)AMINO]PHOSPHORYL}-L-SERINE'>SXE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [~~http~~://pdbe.org/2jgf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jgf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgf OCA], [https://pdbe.org/2jgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgf RCSB], [https://www.ebi.ac.uk/pdbsum/2jgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]