2jje - Revision history

OCA at 10:42, 16 September 2020

OCA — Wed, 16 Sep 2020 10:42:18 GMT

←Older revision		Revision as of 10:42, 16 September 2020
Line 1:		Line 1:

	==Crystal structure of T330S mutant of Rv3290c from M. tuberculosis==		==Crystal structure of T330S mutant of Rv3290c from M. tuberculosis==
-	<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2jje' size='340' side='right'caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjf\|2jjf]], [[2jjg\|2jjg]], [[2jjh\|2jjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjf\|2jjf]], [[2jjg\|2jjg]], [[2jjh\|2jjh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://pdbe.org/2jje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jje ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://pdbe.org/2jje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jje ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Aminotransferase\|Aminotransferase]]	+	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
		+	[[Category: Large Structures]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Tripathi, S M]]		[[Category: Tripathi, S M]]

OCA at 08:13, 12 December 2018

OCA — Wed, 12 Dec 2018 08:13:16 GMT

←Older revision		Revision as of 08:13, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjf\|2jjf]], [[2jjg\|2jjg]], [[2jjh\|2jjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjf\|2jjf]], [[2jjg\|2jjg]], [[2jjh\|2jjh]]</td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jje_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jje_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:03, 25 January 2017

OCA — Wed, 25 Jan 2017 16:03:49 GMT

←Older revision		Revision as of 16:03, 25 January 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ T330S ~~MUTANT OF RV3290C FROM~~ M. ~~TUBERCULOSIS~~==	+
		+	==Crystal structure of T330S mutant of Rv3290c from M. tuberculosis==
	<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[~~2cjg~~\|~~2cjg~~]], [[~~2cjd~~\|~~2cjd~~]], [[~~2cin~~\|~~2cin]], [[2cjh\|2cjh~~]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjf\|2jjf]], [[2jjg\|2jjg]], [[2jjh\|2jjh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://pdbe.org/2jje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://pdbe.org/2jje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jje ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jje ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jje ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine varepsilon-aminotransferase (LAT) converts lysine to alpha-aminoadipate-delta-semialdehyde in a PLP-mediated reaction. We mutated active-site T330, N328 and E243, and structurally rationalized their properties. T330A and T330S mutants cannot bind PLP and are inactive. N328A although inactive, binds to PLP. E243A retains activity, but binds alpha-ketoglutarate in a different conformation. We had earlier identified 2-aminomethyl piperidine derivative as a LAT inhibitor. The co-crystal structure reveals that it mimics binding of C5 substrates and exhibits two binding modes. E243, that shields R422 in the apo enzyme, exhibits conformational changes to permit the binding of the inhibitor in one of the binding modes. Structure-based analysis of bound water in the active site suggests optimization strategies for synthesis of improved inhibitors.
		+
		+	Mutational analysis of Mycobacterium tuberculosis lysine varepsilon-aminotransferase and inhibitor co-crystal structures, reveals distinct binding modes.,Tripathi SM, Agarwal A, Ramachandran R Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):154-60. doi:, 10.1016/j.bbrc.2015.05.055. Epub 2015 May 20. PMID:26003725<ref>PMID:26003725</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2jje" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Aminotransferase\|Aminotransferase]]		*[[Aminotransferase\|Aminotransferase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:38, 7 February 2016

OCA — Sun, 07 Feb 2016 11:38:07 GMT

←Older revision		Revision as of 11:38, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jje ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase\|Aminotransferase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 01:07, 10 September 2015

OCA — Thu, 10 Sep 2015 01:07:49 GMT

←Older revision		Revision as of 01:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjg\|2cjg]], [[2cjd\|2cjd]], [[2cin\|2cin]], [[2cjh\|2cjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjg\|2cjg]], [[2cjd\|2cjd]], [[2cin\|2cin]], [[2cjh\|2cjh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://pdbe.org/2jje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Tripathi, S M]]		[[Category: Tripathi, S M]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Lysine amino transferase]]		[[Category: Lysine amino transferase]]
		+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Plp]]		[[Category: Plp]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

OCA at 14:13, 19 January 2015

OCA — Mon, 19 Jan 2015 14:13:33 GMT

←Older revision		Revision as of 14:13, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjg\|2cjg]], [[2cjd\|2cjd]], [[2cin\|2cin]], [[2cjh\|2cjh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjg\|2cjg]], [[2cjd\|2cjd]], [[2cin\|2cin]], [[2cjh\|2cjh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Ramachandran, R.]]	+	[[Category: Ramachandran, R]]
-	[[Category: Tripathi, S M.]]	+	[[Category: Tripathi, S M]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Lysine amino transferase]]		[[Category: Lysine amino transferase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Plp]]		[[Category: Plp]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

OCA at 08:13, 30 September 2014

OCA — Tue, 30 Sep 2014 08:13:11 GMT

←Older revision		Revision as of 08:13, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2jje.png\|left\|200px]]~~	+	==CRYSTAL STRUCTURE OF T330S MUTANT OF RV3290C FROM M. TUBERCULOSIS==
-		+	<StructureSection load='2jje' size='340' side='right' caption='[[2jje]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{STRUCTURE_2jje\| PDB=2jje \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJE FirstGlance]. <br>
-	===CRYSTAL STRUCTURE OF T330S MUTANT OF RV3290C FROM M. TUBERCULOSIS===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjg\|2cjg]], [[2cjd\|2cjd]], [[2cin\|2cin]], [[2cjh\|2cjh]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jje RCSB], [http://www.ebi.ac.uk/pdbsum/2jje PDBsum]</span></td></tr>
-	[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jje_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2jje" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:16:13 GMT

Protected "2jje" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:16, 7 January 2013

OCA at 13:16, 7 January 2013

OCA — Mon, 07 Jan 2013 13:16:09 GMT

←Older revision		Revision as of 13:16, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2jje.png\|left\|200px]]
-	[[Image:2jje.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jje", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jje\| PDB=2jje \| SCENE= }}		{{STRUCTURE_2jje\| PDB=2jje \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2JJE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA].	+	[[2jje]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA].
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 27:		Line 20:
	[[Category: T330s mutant]]		[[Category: T330s mutant]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:32:23 2009''

OCA at 06:32, 1 July 2009

OCA — Wed, 01 Jul 2009 06:32:26 GMT

←Older revision		Revision as of 06:32, 1 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2jje.jpg\|left\|200px]]

-	The ~~entry 2jje~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2jje", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2jje\| PDB=2jje \| SCENE= }}

-	~~Authors: Tripathi, S.~~M.~~, Ramachandran, R.~~	+	===CRYSTAL STRUCTURE OF T330S MUTANT OF RV3290C FROM M. TUBERCULOSIS===

-	Description: Crystal structure of T330S mutant of Rv3290c from M. tuberculosis

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Jul ~~11 12~~:58:~~56 2008~~''	+	==About this Structure==
		+	2JJE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJE OCA].
		+	[[Category: L-lysine 6-transaminase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Ramachandran, R.]]
		+	[[Category: Tripathi, S M.]]
		+	[[Category: Aminotransferase]]
		+	[[Category: Lysine amino transferase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Plp]]
		+	[[Category: Pyridoxal phosphate]]
		+	[[Category: Rv3290c]]
		+	[[Category: T330s mutant]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:32:23 2009''