2jju - Revision history

OCA at 14:51, 13 December 2023

OCA — Wed, 13 Dec 2023 14:51:56 GMT

←Older revision		Revision as of 14:51, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jju' size='340' side='right'caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='2jju' size='340' side='right'caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.19Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2jjv\|2jjv]]~~, ~~[[2jjw\|2jjw]], [[2uv3\|2uv3]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [https://pdbe.org/2jju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [https://www.ebi.ac.uk/pdbsum/2jju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [https://pdbe.org/2jju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [https://www.ebi.ac.uk/pdbsum/2jju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SIRB1_HUMAN SIRB1_HUMAN]] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.	+	[https://www.uniprot.org/uniprot/SIRB1_HUMAN SIRB1_HUMAN] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barclay~~, A N~~]]	+	[[Category: Barclay AN]]
-	[[Category: Graham~~, S C~~]]	+	[[Category: Graham SC]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Hatherley, D]]	+	[[Category: Hatherley D]]
-	[[Category: Stuart~~, D I~~]]	+	[[Category: Stuart DI]]
-	[[Category: Turner, J]]	+	[[Category: Turner J]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Immunoglobulin superfamily]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Paired receptor]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Signal regulatory protein beta]]~~	+
-	~~[[Category: Sirp]]~~	+
-	~~[[Category: Sirpb1]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 11:27, 31 March 2021

OCA — Wed, 31 Mar 2021 11:27:23 GMT

←Older revision		Revision as of 11:27, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='2jju' size='340' side='right'caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='2jju' size='340' side='right'caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JJU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [~~http~~://pdbe.org/2jju PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jju PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [https://pdbe.org/2jju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [https://www.ebi.ac.uk/pdbsum/2jju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SIRB1_HUMAN SIRB1_HUMAN]] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.	+	[[https://www.uniprot.org/uniprot/SIRB1_HUMAN SIRB1_HUMAN]] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:27, 3 April 2019

OCA — Wed, 03 Apr 2019 07:27:50 GMT

←Older revision		Revision as of 07:27, 3 April 2019
Line 1:		Line 1:

	==Structure of human signal regulatory protein (sirp) beta==		==Structure of human signal regulatory protein (sirp) beta==
-	<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>	+	<StructureSection load='2jju' size='340' side='right'caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barclay, A N]]		[[Category: Barclay, A N]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 06:59, 11 July 2018

OCA — Wed, 11 Jul 2018 06:59:13 GMT

←Older revision		Revision as of 06:59, 11 July 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN~~ (~~SIRP~~) ~~BETA~~==	+
		+	==Structure of human signal regulatory protein (sirp) beta==
	<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://pdbe.org/2jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://pdbe.org/2jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jju ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jju_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jju_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 40:
	[[Category: Stuart, D I]]		[[Category: Stuart, D I]]
	[[Category: Turner, J]]		[[Category: Turner, J]]
		+	[[Category: Alternative splicing]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune system]]		[[Category: Immune system]]
Line 45:		Line 47:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Paired receptor]]		[[Category: Paired receptor]]
		+	[[Category: Polymorphism]]
	[[Category: Signal regulatory protein beta]]		[[Category: Signal regulatory protein beta]]
	[[Category: Sirp]]		[[Category: Sirp]]
	[[Category: Sirpb1]]		[[Category: Sirpb1]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 22:05, 8 February 2016

OCA — Mon, 08 Feb 2016 22:05:58 GMT

←Older revision		Revision as of 22:05, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jju ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:48, 10 September 2015

OCA — Thu, 10 Sep 2015 15:48:41 GMT

←Older revision		Revision as of 15:48, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://pdbe.org/2jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jju" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barclay, A N]]		[[Category: Barclay, A N]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 02:27, 25 December 2014

OCA — Thu, 25 Dec 2014 02:27:09 GMT

←Older revision		Revision as of 02:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIRB1_HUMAN SIRB1_HUMAN]] Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barclay, A N.]]	+	[[Category: Barclay, A N]]
-	[[Category: Graham, S C.]]	+	[[Category: Graham, S C]]
-	[[Category: Harlos, K.]]	+	[[Category: Harlos, K]]
-	[[Category: Hatherley, D.]]	+	[[Category: Hatherley, D]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
-	[[Category: Turner, J.]]	+	[[Category: Turner, J]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 10:43, 30 September 2014

OCA — Tue, 30 Sep 2014 10:43:32 GMT

←Older revision		Revision as of 10:43, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jju.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA==
		+	<StructureSection load='2jju' size='340' side='right' caption='[[2jju]], [[Resolution\|resolution]] 1.19Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jjv\|2jjv]], [[2jjw\|2jjw]], [[2uv3\|2uv3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jju RCSB], [http://www.ebi.ac.uk/pdbsum/2jju PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jju_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells. We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresponding regions in SIRPalpha. We have also determined structures of the N-terminal domains of SIRPbeta, SIRPbeta(2), and SIRPgamma; proteins that are closely related to SIRPalpha but bind CD47 with negligible or reduced affinity. These results explain the specificity of CD47 for the SIRP family of paired receptors in atomic detail. Analysis of SIRPalpha polymorphisms suggests that these, as well as the activating SIRPs, may have evolved to counteract pathogen binding to the inhibitory SIRPalpha receptor.

-	~~{{STRUCTURE_2jju\| PDB=2jju \| SCENE= }}~~	+	Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.,Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508<ref>PMID:18657508</ref>

-	~~===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18657508}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jju]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018657508<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barclay, A N.]]		[[Category: Barclay, A N.]]

OCA: Protected "2jju" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 15:12:24 GMT

Protected "2jju" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:12, 7 January 2013

OCA at 15:12, 7 January 2013

OCA — Mon, 07 Jan 2013 15:12:22 GMT

←Older revision		Revision as of 15:12, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jju.png\|left\|200px]]		[[Image:2jju.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jju", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jju\| PDB=2jju \| SCENE= }}		{{STRUCTURE_2jju\| PDB=2jju \| SCENE= }}

	===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA===		===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) BETA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18657508}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18657508 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18657508}}		{{ABSTRACT_PUBMED_18657508}}

	==About this Structure==		==About this Structure==
-	~~2JJU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA].	+	[[2jju]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18657508~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018657508</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barclay, A N.]]		[[Category: Barclay, A N.]]
Line 31:		Line 19:
	[[Category: Stuart, D I.]]		[[Category: Stuart, D I.]]
	[[Category: Turner, J.]]		[[Category: Turner, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune system]]		[[Category: Immune system]]
Line 38:		Line 25:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Paired receptor]]		[[Category: Paired receptor]]
-	[[Category: Polymorphism]]
	[[Category: Signal regulatory protein beta]]		[[Category: Signal regulatory protein beta]]
	[[Category: Sirp]]		[[Category: Sirp]]
	[[Category: Sirpb1]]		[[Category: Sirpb1]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:52:37 2009''