2jjw - Revision history

OCA at 14:52, 13 December 2023

OCA — Wed, 13 Dec 2023 14:52:04 GMT

←Older revision		Revision as of 14:52, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jjw' size='340' side='right'caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jjw' size='340' side='right'caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2jju\|2jju]]~~, [[~~2jjv~~\|~~2jjv~~]]~~, [[2uv3\|2uv3]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [https://pdbe.org/2jjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [https://www.ebi.ac.uk/pdbsum/2jjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [https://pdbe.org/2jjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [https://www.ebi.ac.uk/pdbsum/2jjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>	+	[https://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barclay~~, A N~~]]	+	[[Category: Barclay AN]]
-	[[Category: Graham~~, S C~~]]	+	[[Category: Graham SC]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Hatherley, D]]	+	[[Category: Hatherley D]]
-	[[Category: Stuart~~, D I~~]]	+	[[Category: Stuart DI]]
-	[[Category: Turner, J]]	+	[[Category: Turner J]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Immunoglobulin superfamily]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Paired receptor]]~~	+
-	~~[[Category: Signal regulatory protein gamma]]~~	+
-	~~[[Category: Sirp]]~~	+
-	~~[[Category: Sirpg]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 11:27, 31 March 2021

OCA — Wed, 31 Mar 2021 11:27:30 GMT

←Older revision		Revision as of 11:27, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='2jjw' size='340' side='right'caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jjw' size='340' side='right'caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [~~http~~://pdbe.org/2jjw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jjw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [https://pdbe.org/2jjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [https://www.ebi.ac.uk/pdbsum/2jjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>	+	[[https://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:28, 3 April 2019

OCA — Wed, 03 Apr 2019 07:28:07 GMT

←Older revision		Revision as of 07:28, 3 April 2019
Line 1:		Line 1:

	==Structure of human signal regulatory protein (sirp) gamma==		==Structure of human signal regulatory protein (sirp) gamma==
-	<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2jjw' size='340' side='right'caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barclay, A N]]		[[Category: Barclay, A N]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 06:53, 11 July 2018

OCA — Wed, 11 Jul 2018 06:53:13 GMT

←Older revision		Revision as of 06:53, 11 July 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN~~ (~~SIRP~~) ~~GAMMA~~==	+
		+	==Structure of human signal regulatory protein (sirp) gamma==
	<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://pdbe.org/2jjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://pdbe.org/2jjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Stuart, D I]]		[[Category: Stuart, D I]]
	[[Category: Turner, J]]		[[Category: Turner, J]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 15:11, 9 February 2016

OCA — Tue, 09 Feb 2016 15:11:06 GMT

←Older revision		Revision as of 15:11, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:27, 10 September 2015

OCA — Thu, 10 Sep 2015 23:27:23 GMT

←Older revision		Revision as of 23:27, 10 September 2015
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	<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://pdbe.org/2jjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jjw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barclay, A N]]		[[Category: Barclay, A N]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 07:37, 25 December 2014

OCA — Thu, 25 Dec 2014 07:37:24 GMT

←Older revision		Revision as of 07:37, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barclay, A N.]]	+	[[Category: Barclay, A N]]
-	[[Category: Graham, S C.]]	+	[[Category: Graham, S C]]
-	[[Category: Harlos, K.]]	+	[[Category: Harlos, K]]
-	[[Category: Hatherley, D.]]	+	[[Category: Hatherley, D]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
-	[[Category: Turner, J.]]	+	[[Category: Turner, J]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 08:46, 30 September 2014

OCA — Tue, 30 Sep 2014 08:46:30 GMT

←Older revision		Revision as of 08:46, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jjw.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) GAMMA==
		+	<StructureSection load='2jjw' size='340' side='right' caption='[[2jjw]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jju\|2jju]], [[2jjv\|2jjv]], [[2uv3\|2uv3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjw RCSB], [http://www.ebi.ac.uk/pdbsum/2jjw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells. We describe the high-resolution X-ray crystallographic structures of the immunoglobulin superfamily domain of CD47 alone and in complex with the N-terminal ligand-binding domain of signal regulatory protein alpha (SIRPalpha). The unusual and convoluted interacting face of CD47, comprising the N terminus and loops at the end of the domain, intercalates with the corresponding regions in SIRPalpha. We have also determined structures of the N-terminal domains of SIRPbeta, SIRPbeta(2), and SIRPgamma; proteins that are closely related to SIRPalpha but bind CD47 with negligible or reduced affinity. These results explain the specificity of CD47 for the SIRP family of paired receptors in atomic detail. Analysis of SIRPalpha polymorphisms suggests that these, as well as the activating SIRPs, may have evolved to counteract pathogen binding to the inhibitory SIRPalpha receptor.

-	~~{{STRUCTURE_2jjw\| PDB=2jjw \| SCENE= }}~~	+	Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.,Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508<ref>PMID:18657508</ref>

-	~~===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) GAMMA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18657508}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jjw]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018657508<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barclay, A N.]]		[[Category: Barclay, A N.]]

OCA: Protected "2jjw" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:08:03 GMT

Protected "2jjw" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 7 January 2013

OCA at 11:08, 7 January 2013

OCA — Mon, 07 Jan 2013 11:08:00 GMT

←Older revision		Revision as of 11:08, 7 January 2013
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-	{{Seed}}
	[[Image:2jjw.png\|left\|200px]]		[[Image:2jjw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jjw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jjw\| PDB=2jjw \| SCENE= }}		{{STRUCTURE_2jjw\| PDB=2jjw \| SCENE= }}

	===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) GAMMA===		===STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) GAMMA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18657508}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18657508 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18657508}}		{{ABSTRACT_PUBMED_18657508}}

	==About this Structure==		==About this Structure==
-	~~2JJW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA].	+	[[2jjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18657508~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018657508</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barclay, A N.]]		[[Category: Barclay, A N.]]
Line 31:		Line 19:
	[[Category: Stuart, D I.]]		[[Category: Stuart, D I.]]
	[[Category: Turner, J.]]		[[Category: Turner, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
Line 42:		Line 29:
	[[Category: Sirpg]]		[[Category: Sirpg]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:43:50 2009''