2jjx - Revision history

OCA at 14:52, 13 December 2023

OCA — Wed, 13 Dec 2023 14:52:08 GMT

←Older revision		Revision as of 14:52, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jjx' size='340' side='right'caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='2jjx' size='340' side='right'caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacillus_anthracis_(strain_ames)~~ Bacillus anthracis ~~(strain ames)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.82Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/UMP_kinase UMP kinase]~~, ~~with EC number [https~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [https://pdbe.org/2jjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [https://www.ebi.ac.uk/pdbsum/2jjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [https://pdbe.org/2jjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [https://www.ebi.ac.uk/pdbsum/2jjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6L7HKK4_BACAN A0A6L7HKK4_BACAN] Catalyzes the reversible phosphorylation of UMP to UDP.[HAMAP-Rule:MF_01220]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus anthracis str. Ames]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: UMP kinase]]~~	+	[[Category: Carter LG]]
-	[[Category: Carter~~, L G~~]]	+	[[Category: Esnouf RM]]
-	[[Category: Esnouf~~, R M~~]]	+	[[Category: Mancini EJ]]
-	[[Category: Mancini~~, E J~~]]	+	[[Category: Meier C]]
-	[[Category: Meier, C]]	+	[[Category: Owens RJ]]
-	~~[[Category: OPPF, Oxford Protein Production Facility~~]]	+	[[Category: Stuart DI]]
-	[[Category: Owens~~, R J]]~~	+
-	~~[[Category: SPINE, Structural Proteomics in Europe~~]]	+
-	[[Category: Stuart~~, D I]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Oppf]]~~	+
-	~~[[Category: Pyrh]]~~	+
-	~~[[Category: Pyrimidine biosynthesis]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Uridylate kinase~~]]	+

OCA at 11:27, 31 March 2021

OCA — Wed, 31 Mar 2021 11:27:31 GMT

←Older revision		Revision as of 11:27, 31 March 2021
Line 1:		Line 1:

	==THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)==		==THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)==
-	<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>	+	<StructureSection load='2jjx' size='340' side='right'caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [~~http~~://pdbe.org/2jjx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jjx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [https://pdbe.org/2jjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [https://www.ebi.ac.uk/pdbsum/2jjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: UMP kinase]]		[[Category: UMP kinase]]
	[[Category: Carter, L G]]		[[Category: Carter, L G]]

OCA at 16:21, 27 February 2019

OCA — Wed, 27 Feb 2019 16:21:52 GMT

←Older revision		Revision as of 16:21, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:18, 24 May 2017

OCA — Wed, 24 May 2017 07:18:25 GMT

←Older revision		Revision as of 07:18, 24 May 2017
Line 1:		Line 1:
		+
	==THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)==		==THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)==
	<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://pdbe.org/2jjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://pdbe.org/2jjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 38:		Line 39:
	[[Category: Mancini, E J]]		[[Category: Mancini, E J]]
	[[Category: Meier, C]]		[[Category: Meier, C]]
-	[[Category: ~~Oppf~~, Oxford Protein Production Facility]]	+	[[Category: OPPF, Oxford Protein Production Facility]]
	[[Category: Owens, R J]]		[[Category: Owens, R J]]
-	[[Category: ~~Spine~~, Structural Proteomics in Europe]]	+	[[Category: SPINE, Structural Proteomics in Europe]]
	[[Category: Stuart, D I]]		[[Category: Stuart, D I]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
		+	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]

OCA at 05:53, 10 February 2016

OCA — Wed, 10 Feb 2016 05:53:00 GMT

←Older revision		Revision as of 05:53, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:59, 11 September 2015

OCA — Fri, 11 Sep 2015 05:59:50 GMT

←Older revision		Revision as of 05:59, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>		<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis~~ Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://pdbe.org/2jjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jjx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus anthracis]]
	[[Category: UMP kinase]]		[[Category: UMP kinase]]
	[[Category: Carter, L G]]		[[Category: Carter, L G]]

OCA at 16:18, 19 January 2015

OCA — Mon, 19 Jan 2015 16:18:52 GMT

←Older revision		Revision as of 16:18, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: UMP kinase]]		[[Category: UMP kinase]]
-	[[Category: Carter, L G.]]	+	[[Category: Carter, L G]]
-	[[Category: Esnouf, R M.]]	+	[[Category: Esnouf, R M]]
-	[[Category: Mancini, E J.]]	+	[[Category: Mancini, E J]]
-	[[Category: Meier, C.]]	+	[[Category: Meier, C]]
-	[[Category: Oppf, Oxford Protein Production Facility.]]	+	[[Category: Oppf, Oxford Protein Production Facility]]
-	[[Category: Owens, R J.]]	+	[[Category: Owens, R J]]
-	[[Category: Spine, Structural Proteomics in Europe.]]	+	[[Category: Spine, Structural Proteomics in Europe]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 03:22, 29 September 2014

OCA — Mon, 29 Sep 2014 03:22:20 GMT

←Older revision		Revision as of 03:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jjx.~~png\|left~~\|200px]]	+	==THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)==
		+	<StructureSection load='2jjx' size='340' side='right' caption='[[2jjx]], [[Resolution\|resolution]] 2.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jjx RCSB], [http://www.ebi.ac.uk/pdbsum/2jjx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Uridine monophosphate (UMP) kinase is a conserved enzyme that catalyzes the ATP-driven conversion of uridylate monophosphate into uridylate diphosphate, an essential metabolic step. In prokaryotes, the enzyme exists as a homohexamer that is regulated by various metabolites. Whereas the enzymatic mechanism of UMP kinase (UK) is well-characterized, the molecular basis of its regulation remains poorly understood. Here we report the crystal structure of UK from Bacillus anthracis (BA1797) in complex with ATP at 2.82 A resolution. It reveals that the cofactor, in addition to binding in the active sites, also interacts with separate binding pockets located near the center of the hexameric structure. The existence of such an allosteric binding site had been predicted by biochemical studies, but it was not identified in previous crystal structures of prokaryotic UKs. We show that this putative allosteric pocket is conserved across different bacterial species, suggesting that it is a feature common to bacterial UKs, and we present a structural model for the allosteric regulation of this enzyme.

-	~~{{STRUCTURE_2jjx\| PDB=2jjx \| SCENE= }}~~	+	The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site.,Meier C, Carter LG, Sainsbury S, Mancini EJ, Owens RJ, Stuart DI, Esnouf RM J Mol Biol. 2008 Sep 19;381(5):1098-105. Epub 2008 Jul 3. PMID:18625239<ref>PMID:18625239</ref>

-	~~===THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18625239}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jjx]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_anthracis Bacillus anthracis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA].~~	+

	==See Also==		==See Also==
	*[[Uridylate kinase\|Uridylate kinase]]		*[[Uridylate kinase\|Uridylate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018625239<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: UMP kinase]]		[[Category: UMP kinase]]

OCA at 16:33, 20 October 2012

OCA — Sat, 20 Oct 2012 16:33:18 GMT

←Older revision		Revision as of 16:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jjx]] is a 3 chain structure ~~of [[Uridylate kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA].	+	[[2jjx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJX OCA].

	==See Also==		==See Also==

OCA: Protected "2jjx" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 22:03:51 GMT

Protected "2jjx" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:03, 26 July 2012