2jk3 - Revision history

OCA at 14:52, 13 December 2023

OCA — Wed, 13 Dec 2023 14:52:17 GMT

←Older revision		Revision as of 14:52, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jk3' size='340' side='right'caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right'caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_14579 Atcc 14579~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2jj7\|2jj7]], [[2fx0\|2fx0]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [https://pdbe.org/2jk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [https://pdbe.org/2jk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7X506_BACCE Q7X506_BACCE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 14579~~]]	+	[[Category: Bacillus cereus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antson~~, A A~~]]	+	[[Category: Antson AA]]
-	[[Category: Kovalevskiy~~, O V~~]]	+	[[Category: Kovalevskiy OV]]
-	[[Category: Solonin~~, A S]]~~	+	[[Category: Solonin AS]]
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Tetr family]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcriptional regulator~~]]	+

OCA at 08:12, 19 January 2022

OCA — Wed, 19 Jan 2022 08:12:58 GMT

←Older revision		Revision as of 08:12, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2jk3' size='340' side='right'caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right'caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jj7\|2jj7]], [[2fx0\|2fx0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [~~http~~://pdbe.org/2jk3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [https://pdbe.org/2jk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:53, 15 April 2020

OCA — Wed, 15 Apr 2020 07:53:39 GMT

←Older revision		Revision as of 07:53, 15 April 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE HLYIIR MUTANT PROTEIN WITH RESIDUES 169-186 SUBSTITUTED BY GSSGSSG LINKER==		==CRYSTAL STRUCTURE OF THE HLYIIR MUTANT PROTEIN WITH RESIDUES 169-186 SUBSTITUTED BY GSSGSSG LINKER==
-	<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2jk3' size='340' side='right'caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://pdbe.org/2jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://pdbe.org/2jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 14579]]		[[Category: Atcc 14579]]
		+	[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Kovalevskiy, O V]]		[[Category: Kovalevskiy, O V]]

OCA at 06:57, 11 July 2018

OCA — Wed, 11 Jul 2018 06:57:15 GMT

←Older revision		Revision as of 06:57, 11 July 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE HLYIIR MUTANT PROTEIN WITH RESIDUES 169-186 SUBSTITUTED BY GSSGSSG LINKER==		==CRYSTAL STRUCTURE OF THE HLYIIR MUTANT PROTEIN WITH RESIDUES 169-186 SUBSTITUTED BY GSSGSSG LINKER==
	<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://pdbe.org/2jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://pdbe.org/2jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jk3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jk3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:03, 8 February 2016

OCA — Mon, 08 Feb 2016 01:03:48 GMT

←Older revision		Revision as of 01:03, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jk3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:26, 10 September 2015

OCA — Thu, 10 Sep 2015 06:26:29 GMT

←Older revision		Revision as of 06:26, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus Bacillus cereus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://pdbe.org/2jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jk3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus cereus~~]]	+	[[Category: Atcc 14579]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Kovalevskiy, O V]]		[[Category: Kovalevskiy, O V]]

OCA at 18:06, 19 January 2015

OCA — Mon, 19 Jan 2015 18:06:33 GMT

←Older revision		Revision as of 18:06, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
-	[[Category: Antson, A A.]]	+	[[Category: Antson, A A]]
-	[[Category: Kovalevskiy, O V.]]	+	[[Category: Kovalevskiy, O V]]
-	[[Category: Solonin, A S.]]	+	[[Category: Solonin, A S]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]

OCA at 09:58, 3 October 2014

OCA — Fri, 03 Oct 2014 09:58:30 GMT

←Older revision		Revision as of 09:58, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK3 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>
	<table>		<table>
Line 24:		Line 23:
	Structural investigation of transcriptional regulator HlyIIR: Influence of a disordered region on protein fold and dimerization.,Kovalevskiy OV, Solonin AS, Antson AA Proteins. 2010 Feb 3. PMID:20225260<ref>PMID:20225260</ref>		Structural investigation of transcriptional regulator HlyIIR: Influence of a disordered region on protein fold and dimerization.,Kovalevskiy OV, Solonin AS, Antson AA Proteins. 2010 Feb 3. PMID:20225260<ref>PMID:20225260</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:41, 1 May 2014

OCA — Thu, 01 May 2014 09:41:28 GMT

←Older revision		Revision as of 09:41, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jk3' size='340' side='right' caption='[[2jk3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. <br>	+	<table><tr><td colspan='2'>[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. <br>
-	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-	<b>[[Related_structure\|Related:]]</b> [[2jj7\|2jj7]], [[2fx0\|2fx0]]<br>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jj7\|2jj7]], [[2fx0\|2fx0]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 17:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	B. cereus HlyIIR belongs to the TetR family of dimeric transcriptional regulators. Unlike other members of the TetR family, HlyIIR contains an insert between alpha-helices alpha8 and alpha9, which is located at the subunit-subunit interface. N-terminal segment of this insert (amino acids, Pro161-Ser169) forms a short alpha-helix alpha8* that occupies a complementary cavity on the surface of the adjacent subunit, whereas the C-terminal segment comprising 16 amino acids (Leu170-Glu185) is disordered. To understand whether this disordered segment is important for protein's function, we determined crystal structures of two engineered HlyIIR proteins where this segment was either substituted by a seven-residue flexible Ser-Gly linker or replaced by a cleavable peptide containing proteolytic sites at both ends. Unexpectedly, alteration or proteolytic removal of the disordered segment resulted in changes in protein's conformation and in a remarkable rearrangement at the subunit-subunit interface. X-ray structures of the two engineered proteins revealed an unusual plasticity at the dimerization interface of HlyIIR enabling it to form dimers stabilized by different sets of interactions. Structural comparison indicates that in spite of the flexible nature of the disordered segment, it is critical for maintaining the native structure as it influences the position of alpha8*. The data demonstrate how disordered loops on protein surfaces may affect folding and subunit-subunit interactions. Proteins 2010. (c) 2010 Wiley-Liss, Inc.		B. cereus HlyIIR belongs to the TetR family of dimeric transcriptional regulators. Unlike other members of the TetR family, HlyIIR contains an insert between alpha-helices alpha8 and alpha9, which is located at the subunit-subunit interface. N-terminal segment of this insert (amino acids, Pro161-Ser169) forms a short alpha-helix alpha8* that occupies a complementary cavity on the surface of the adjacent subunit, whereas the C-terminal segment comprising 16 amino acids (Leu170-Glu185) is disordered. To understand whether this disordered segment is important for protein's function, we determined crystal structures of two engineered HlyIIR proteins where this segment was either substituted by a seven-residue flexible Ser-Gly linker or replaced by a cleavable peptide containing proteolytic sites at both ends. Unexpectedly, alteration or proteolytic removal of the disordered segment resulted in changes in protein's conformation and in a remarkable rearrangement at the subunit-subunit interface. X-ray structures of the two engineered proteins revealed an unusual plasticity at the dimerization interface of HlyIIR enabling it to form dimers stabilized by different sets of interactions. Structural comparison indicates that in spite of the flexible nature of the disordered segment, it is critical for maintaining the native structure as it influences the position of alpha8*. The data demonstrate how disordered loops on protein surfaces may affect folding and subunit-subunit interactions. Proteins 2010. (c) 2010 Wiley-Liss, Inc.
Line 23:		Line 25:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:02, 30 April 2014

OCA — Wed, 30 Apr 2014 10:02:13 GMT

←Older revision		Revision as of 10:02, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. <br>		[[2jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK3 OCA]. <br>
-	<b>Related:</b> [[2jj7\|2jj7]], [[2fx0\|2fx0]]<br>	+	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<b>[[Related_structure\|Related:]]</b> [[2jj7\|2jj7]], [[2fx0\|2fx0]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk3 PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]