2jm4 - Revision history

OCA at 10:06, 20 December 2023

OCA — Wed, 20 Dec 2023 10:06:46 GMT

←Older revision		Revision as of 10:06, 20 December 2023
Line 1:		Line 1:

	==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==		==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==
-	<StructureSection load='2jm4' size='340' side='right'caption='[[2jm4~~]], [[NMR_Ensembles_of_Models \| 24 NMR models~~]]' scene=''>	+	<StructureSection load='2jm4' size='340' side='right'caption='[[2jm4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RXFP1, LGR7 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [https://pdbe.org/2jm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [https://pdbe.org/2jm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RXFP1_HUMAN RXFP1_HUMAN]] Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.	+	[https://www.uniprot.org/uniprot/RXFP1_HUMAN RXFP1_HUMAN] Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bathgate~~, R A.D~~]]	+	[[Category: Bathgate RAD]]
-	[[Category: Gooley~~, P R~~]]	+	[[Category: Gooley PR]]
-	[[Category: Hopkins~~, E J]]~~	+	[[Category: Hopkins EJ]]
-	~~[[Category: Ldl-a module]]~~	+
-	~~[[Category: Lgr7]]~~	+
-	~~[[Category: Rxfp1 receptor]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:27, 31 March 2021

OCA — Wed, 31 Mar 2021 11:27:53 GMT

←Older revision		Revision as of 11:27, 31 March 2021
Line 1:		Line 1:

	==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==		==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==
-	<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>	+	<StructureSection load='2jm4' size='340' side='right'caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [~~http~~://pdbe.org/2jm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [https://pdbe.org/2jm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RXFP1_HUMAN RXFP1_HUMAN]] Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.	+	[[https://www.uniprot.org/uniprot/RXFP1_HUMAN RXFP1_HUMAN]] Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bathgate, R A.D]]		[[Category: Bathgate, R A.D]]
	[[Category: Gooley, P R]]		[[Category: Gooley, P R]]

OCA at 06:32, 11 July 2018

OCA — Wed, 11 Jul 2018 06:32:02 GMT

←Older revision		Revision as of 06:32, 11 July 2018
Line 1:		Line 1:
		+
	==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==		==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==
	<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://pdbe.org/2jm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://pdbe.org/2jm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:33, 10 February 2016

OCA — Wed, 10 Feb 2016 02:33:41 GMT

←Older revision		Revision as of 02:33, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jm4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:31, 11 September 2015

OCA — Fri, 11 Sep 2015 04:31:16 GMT

←Older revision		Revision as of 04:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://pdbe.org/2jm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jm4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bathgate, R A.D]]		[[Category: Bathgate, R A.D]]
	[[Category: Gooley, P R]]		[[Category: Gooley, P R]]

OCA at 11:11, 25 December 2014

OCA — Thu, 25 Dec 2014 11:11:10 GMT

←Older revision		Revision as of 11:11, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RXFP1_HUMAN RXFP1_HUMAN]] Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bathgate, R A.D.]]	+	[[Category: Bathgate, R A.D]]
-	[[Category: Gooley, P R.]]	+	[[Category: Gooley, P R]]
-	[[Category: Hopkins, E J.]]	+	[[Category: Hopkins, E J]]
	[[Category: Ldl-a module]]		[[Category: Ldl-a module]]
	[[Category: Lgr7]]		[[Category: Lgr7]]
	[[Category: Rxfp1 receptor]]		[[Category: Rxfp1 receptor]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 07:43, 30 September 2014

OCA — Tue, 30 Sep 2014 07:43:13 GMT

←Older revision		Revision as of 07:43, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jm4.~~png~~\|~~left~~\|200px]]	+	==The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.==
		+	<StructureSection load='2jm4' size='340' side='right' caption='[[2jm4]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXFP1, LGR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The receptors for the peptide hormones relaxin and insulin-like peptide 3 (INSL3) are the leucine-rich repeat-containing G-protein-coupled receptors LGR7 and LGR8 recently renamed as the relaxin family peptide (RXFP) receptors, RXFP1 and RXFP2, respectively. These receptors differ from other LGRs by the addition of an N-terminal low density lipoprotein receptor class A (LDLa) module and are the only human G-protein-coupled receptors to contain such a domain. Recently it was shown that the LDLa module of the RXFP1 and RXFP2 receptors is essential for ligand-stimulated cAMP signaling. The mechanism by which the LDLa module modulates receptor signaling is unknown; however, it represents a unique paradigm in understanding G-protein-coupled receptor signaling. Here we present the structure of the RXFP1 receptor LDLa module determined by solution NMR spectroscopy. The structure is similar to other LDLa modules but shows small differences in side chain orientations and inter-residue packing. Interchange of the module with the second ligand binding domain of the LDL receptor, LB2, results in a receptor that binds relaxin with full affinity but is unable to signal. Furthermore, we demonstrate via structural studies on mutated LDLa modules and functional studies on mutated full-length receptors that a hydrophobic surface within the N-terminal region of the module is essential for activation of RXFP1 receptor signal in response to relaxin stimulation. This study has highlighted the necessity to understand the structural effects of single amino acid mutations on the LDLa module to fully interpret the effects of these mutations on receptor activity.

-	~~{{STRUCTURE_2jm4\| PDB=2jm4 \| SCENE= }}~~	+	The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation.,Hopkins EJ, Layfield S, Ferraro T, Bathgate RA, Gooley PR J Biol Chem. 2007 Feb 9;282(6):4172-84. Epub 2006 Dec 4. PMID:17148455<ref>PMID:17148455</ref>

-	~~===The solution NMR structure~~ of the ~~relaxin (RXFP1) receptor LDLa module~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17148455}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jm4]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017148455<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bathgate, R A.D.]]		[[Category: Bathgate, R A.D.]]

OCA: Protected "2jm4" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:17:24 GMT

Protected "2jm4" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 7 January 2013

OCA at 10:17, 7 January 2013

OCA — Mon, 07 Jan 2013 10:17:21 GMT

←Older revision		Revision as of 10:17, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jm4.png\|left\|200px]]		[[Image:2jm4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jm4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jm4\| PDB=2jm4 \| SCENE= }}		{{STRUCTURE_2jm4\| PDB=2jm4 \| SCENE= }}

	===The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.===		===The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17148455}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17148455 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17148455}}		{{ABSTRACT_PUBMED_17148455}}

	==About this Structure==		==About this Structure==
-	~~2JM4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA].	+	[[2jm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17148455~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017148455</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bathgate, R A.D.]]		[[Category: Bathgate, R A.D.]]
Line 31:		Line 19:
	[[Category: Lgr7]]		[[Category: Lgr7]]
	[[Category: Rxfp1 receptor]]		[[Category: Rxfp1 receptor]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 14:42:50 2009''~~	+

OCA at 12:42, 17 February 2009

OCA — Tue, 17 Feb 2009 12:42:51 GMT

←Older revision		Revision as of 12:42, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JM4 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA].	+	2JM4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM4 OCA].

	==Reference==		==Reference==
-	The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation., Hopkins EJ, Layfield S, Ferraro T, Bathgate RA, Gooley PR, J Biol Chem. 2007 Feb 9;282(6):4172-84. Epub 2006 Dec 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17148455 17148455]~~	+	<ref group="xtra">PMID:17148455</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bathgate, R A.D.]]		[[Category: Bathgate, R A.D.]]
	[[Category: Gooley, P R.]]		[[Category: Gooley, P R.]]
Line 33:		Line 32:
	[[Category: Rxfp1 receptor]]		[[Category: Rxfp1 receptor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:12:~~21 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:42:50 2009''