2jm9 - Revision history

OCA at 10:06, 20 December 2023

OCA — Wed, 20 Dec 2023 10:06:52 GMT

←Older revision		Revision as of 10:06, 20 December 2023
Line 1:		Line 1:

	==R21A Spc-SH3 bound==		==R21A Spc-SH3 bound==
-	<StructureSection load='2jm9' size='340' side='right'caption='[[2jm9~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jm9' size='340' side='right'caption='[[2jm9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2jm8\|2jm8]], [[2jma\|2jma]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [https://pdbe.org/2jm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [https://pdbe.org/2jm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 30:

	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ab, E]]	+	[[Category: Ab E]]
-	[[Category: Casares, S]]	+	[[Category: Casares S]]
-	[[Category: Conejero-Lara, F]]	+	[[Category: Conejero-Lara F]]
-	[[Category: Eshuis, H]]	+	[[Category: Eshuis H]]
-	[[Category: Lopez-Mayorga, O]]	+	[[Category: Lopez-Mayorga O]]
-	[[Category: Nuland~~, N A.J van]]~~	+	[[Category: Van Nuland NAJ]]
-	~~[[Category: P41-bound]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 11:27, 31 March 2021

OCA — Wed, 31 Mar 2021 11:27:57 GMT

←Older revision		Revision as of 11:27, 31 March 2021
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	==R21A Spc-SH3 bound==		==R21A Spc-SH3 bound==
-	<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jm9' size='340' side='right'caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jm8\|2jm8]], [[2jma\|2jma]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [~~http~~://pdbe.org/2jm9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jm9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [https://pdbe.org/2jm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Ab, E]]		[[Category: Ab, E]]
	[[Category: Casares, S]]		[[Category: Casares, S]]

OCA at 07:15, 11 July 2018

OCA — Wed, 11 Jul 2018 07:15:03 GMT

←Older revision		Revision as of 07:15, 11 July 2018
Line 1:		Line 1:
		+
	==R21A Spc-SH3 bound==		==R21A Spc-SH3 bound==
	<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://pdbe.org/2jm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://pdbe.org/2jm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:51, 8 February 2016

OCA — Mon, 08 Feb 2016 13:51:58 GMT

←Older revision		Revision as of 13:51, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jm9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:11, 10 September 2015

OCA — Thu, 10 Sep 2015 12:11:50 GMT

←Older revision		Revision as of 12:11, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 ~~Gallus gallus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://pdbe.org/2jm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~SPTA2_CHICK SPTA2_CHICK~~]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[[http://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jm9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Ab, E]]		[[Category: Ab, E]]
	[[Category: Casares, S]]		[[Category: Casares, S]]

OCA at 23:47, 24 December 2014

OCA — Wed, 24 Dec 2014 23:47:51 GMT

←Older revision		Revision as of 23:47, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPTA2_CHICK SPTA2_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Ab, E.]]	+	[[Category: Ab, E]]
-	[[Category: Casares, S.]]	+	[[Category: Casares, S]]
-	[[Category: Conejero-Lara, F.]]	+	[[Category: Conejero-Lara, F]]
-	[[Category: Eshuis, H.]]	+	[[Category: Eshuis, H]]
-	[[Category: Lopez-Mayorga, O.]]	+	[[Category: Lopez-Mayorga, O]]
-	[[Category: Nuland, N A.J van.]]	+	[[Category: Nuland, N A.J van]]
	[[Category: P41-bound]]		[[Category: P41-bound]]
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 03:45, 29 September 2014

OCA — Mon, 29 Sep 2014 03:45:18 GMT

←Older revision		Revision as of 03:45, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jm9.~~png~~\|~~left~~\|200px]]	+	==R21A Spc-SH3 bound==
		+	<StructureSection load='2jm9' size='340' side='right' caption='[[2jm9]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JM9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jm8\|2jm8]], [[2jma\|2jma]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jm9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jm9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: SH3 domains are small protein modules of 60-85 amino acids that bind to short proline-rich sequences with moderate-to-low affinity and specificity. Interactions with SH3 domains play a crucial role in regulation of many cellular processes (some are related to cancer and AIDS) and have thus been interesting targets in drug design. The decapeptide APSYSPPPPP (p41) binds with relatively high affinity to the SH3 domain of the Abl tyrosine kinase (Abl-SH3), while it has a 100 times lower affinity for the alpha-spectrin SH3 domain (Spc-SH3). RESULTS: Here we present the high-resolution structure of the complex between the R21A mutant of Spc-SH3 and p41 derived from NMR data. Thermodynamic parameters of binding of p41 to both WT and R21A Spc-SH3 were measured by a combination of isothermal titration and differential scanning calorimetry. Mutation of arginine 21 to alanine in Spc-SH3 increases 3- to 4-fold the binding affinity for p41 due to elimination at the binding-site interface of the steric clash produced by the longer arginine side chain. Amide hydrogen-deuterium experiments on the free and p41-bound R21A Spc-SH3 domain indicate that binding elicits a strong reduction in the conformational flexibility of the domain. Despite the great differences in the thermodynamic magnitudes of binding, the structure of the R21A Spc-SH3:P41 complex is remarkably similar to that of the Abl-SH3:P41 complex, with only few differences in protein-ligand contacts at the specificity pocket. Using empirical methods for the prediction of binding energetics based on solvent-accessible surface area calculations, the differences in experimental energetics of binding between the two complexes could not be properly explained only on the basis of the structural differences observed between the complexes. We suggest that the experimental differences in binding energetics can be at least partially ascribed to the absence in the R21A Spc-SH3:P41 complex of several buried water molecules, which have been proposed previously to contribute largely to the highly negative enthalpy and entropy of binding in the Abl-SH3:P41 complex. CONCLUSION: Based on a deep structural and thermodynamic analysis of a low and high affinity complex of two different SH3 domains with the same ligand p41, we underline the importance of taking into account in any effective strategy of rational design of ligands, factors different from the direct protein-ligand interactions, such as the mediation of interactions by water molecules or the existence of cooperative conformational effects induced by binding.

-	~~{{STRUCTURE_2jm9\| PDB=2jm9 \| SCENE= }}~~	+	The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: understanding the determinants of binding affinity by comparison with Abl-SH3.,Casares S, Ab E, Eshuis H, Lopez-Mayorga O, van Nuland NA, Conejero-Lara F BMC Struct Biol. 2007 Apr 2;7:22. PMID:17407569<ref>PMID:17407569</ref>

-	~~===R21A Spc-SH3 bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17407569}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jm9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA].~~	+

	==See Also==		==See Also==
	*[[Spectrin\|Spectrin]]		*[[Spectrin\|Spectrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017407569<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Ab, E.]]		[[Category: Ab, E.]]

OCA at 10:22, 20 October 2012

OCA — Sat, 20 Oct 2012 10:22:15 GMT

←Older revision		Revision as of 10:22, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2jm9]] is a 1 chain structure ~~of [[Spectrin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA].	+	[[2jm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM9 OCA].

	==See Also==		==See Also==

OCA at 01:52, 26 July 2012

OCA — Thu, 26 Jul 2012 01:52:44 GMT

←Older revision		Revision as of 01:52, 26 July 2012
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	[[Image:2jm9.png\|left\|200px]]		[[Image:2jm9.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2jm9\| PDB=2jm9 \| SCENE= }}		{{STRUCTURE_2jm9\| PDB=2jm9 \| SCENE= }}

	===R21A Spc-SH3 bound===		===R21A Spc-SH3 bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17407569}}, adds the Publication Abstract to the page
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	==See Also==		==See Also==
-	*[[Spectrin]]	+	*[[Spectrin\|Spectrin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17407569~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017407569</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Ab, E.]]		[[Category: Ab, E.]]

OCA: Protected "2jm9" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 22:04:00 GMT

Protected "2jm9" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:04, 26 December 2010