2jo7 - Revision history

OCA at 16:38, 13 December 2023

OCA — Wed, 13 Dec 2023 16:38:41 GMT

←Older revision		Revision as of 16:38, 13 December 2023
Line 1:		Line 1:

	==Solution structure of the adhesion protein Bd37 from Babesia divergens==		==Solution structure of the adhesion protein Bd37 from Babesia divergens==
-	<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Babdi Babdi~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [https://pdbe.org/2jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [https://pdbe.org/2jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8T117_BABDI Q8T117_BABDI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Babdi~~]]	+	[[Category: Babesia divergens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arold, S]]	+	[[Category: Arold S]]
-	[[Category: Auguin, D]]	+	[[Category: Auguin D]]
-	[[Category: Delbecq, S]]	+	[[Category: Delbecq S]]
-	[[Category: Gorenflot, A]]	+	[[Category: Gorenflot A]]
-	[[Category: Lohr, F]]	+	[[Category: Lohr F]]
-	[[Category: Precigout, E]]	+	[[Category: Precigout E]]
-	[[Category: Roumestand, C]]	+	[[Category: Roumestand C]]
-	[[Category: Schetters, T]]	+	[[Category: Schetters T]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	~~[[Category: Babesia divergen]]~~	+
-	~~[[Category: Gpi-anchored protein]]~~	+
-	~~[[Category: Recombinant vaccine]]~~	+
-	~~[[Category: Surface active protein]]~~	+
-	~~[[Category: Surface antigen~~]]	+

OCA at 08:15, 19 January 2022

OCA — Wed, 19 Jan 2022 08:15:46 GMT

←Older revision		Revision as of 08:15, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [~~http~~://pdbe.org/2jo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [https://pdbe.org/2jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:56, 15 April 2020

OCA — Wed, 15 Apr 2020 07:56:35 GMT

←Older revision		Revision as of 07:56, 15 April 2020
Line 1:		Line 1:

	==Solution structure of the adhesion protein Bd37 from Babesia divergens==		==Solution structure of the adhesion protein Bd37 from Babesia divergens==
-	<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://pdbe.org/2jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://pdbe.org/2jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Babdi]]		[[Category: Babdi]]
		+	[[Category: Large Structures]]
	[[Category: Arold, S]]		[[Category: Arold, S]]
	[[Category: Auguin, D]]		[[Category: Auguin, D]]

OCA at 06:39, 11 July 2018

OCA — Wed, 11 Jul 2018 06:39:00 GMT

←Older revision		Revision as of 06:39, 11 July 2018
Line 1:		Line 1:
		+
	==Solution structure of the adhesion protein Bd37 from Babesia divergens==		==Solution structure of the adhesion protein Bd37 from Babesia divergens==
	<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://pdbe.org/2jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://pdbe.org/2jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:06, 11 September 2015

OCA — Fri, 11 Sep 2015 03:06:43 GMT

←Older revision		Revision as of 03:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Babesia_divergens Babesia divergens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babdi Babdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://pdbe.org/2jo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jo7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Babesia divergens~~]]	+	[[Category: Babdi]]
	[[Category: Arold, S]]		[[Category: Arold, S]]
	[[Category: Auguin, D]]		[[Category: Auguin, D]]

OCA at 16:27, 19 January 2015

OCA — Mon, 19 Jan 2015 16:27:46 GMT

←Older revision		Revision as of 16:27, 19 January 2015
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Babesia divergens]]		[[Category: Babesia divergens]]
-	[[Category: Arold, S.]]	+	[[Category: Arold, S]]
-	[[Category: Auguin, D.]]	+	[[Category: Auguin, D]]
-	[[Category: Delbecq, S.]]	+	[[Category: Delbecq, S]]
-	[[Category: Gorenflot, A.]]	+	[[Category: Gorenflot, A]]
-	[[Category: Lohr, F.]]	+	[[Category: Lohr, F]]
-	[[Category: Precigout, E.]]	+	[[Category: Precigout, E]]
-	[[Category: Roumestand, C.]]	+	[[Category: Roumestand, C]]
-	[[Category: Schetters, T.]]	+	[[Category: Schetters, T]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Babesia divergen]]		[[Category: Babesia divergen]]
	[[Category: Gpi-anchored protein]]		[[Category: Gpi-anchored protein]]

OCA at 15:32, 12 October 2014

OCA — Sun, 12 Oct 2014 15:32:48 GMT

←Older revision		Revision as of 15:32, 12 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2jo7.~~png\|left\|200px~~]]	+	==Solution structure of the adhesion protein Bd37 from Babesia divergens==
		+	<StructureSection load='2jo7' size='340' side='right' caption='[[2jo7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Babesia divergens is the Apicomplexa agent of the bovine babesiosis in Europe: this infection leads to growth and lactation decrease, so that economical losses due to this parasite are sufficient to require the development of a vaccine. The major surface antigen of B. divergens has been described as a 37 kDa protein glycosyl phosphatidyl inositol (GPI)-anchored at the surface of the merozoite. The immuno-prophylactic potential of Bd37 has been demonstrated, and we present here the high-resolution solution structure of the 27 kDa structured core of Bd37 (Delta-Bd37) using NMR spectroscopy. A model for the whole protein has been obtained using additional small angle X-ray scattering (SAXS) data. The knowledge of the 3D structure of Bd37 allowed the precise epitope mapping of antibodies on its surface. Interestingly, the geometry of Delta-Bd37 reveals an intriguing similarity with the exocyst subunit Exo84p C-terminal region, an eukaryotic protein that has a direct implication in vesicle trafficking. This strongly suggests that Apicomplexa have developed in parallel molecular machines similar in structure and function to the ones used for endo- and exocytosis in eukaryotic cells.

-	~~{{STRUCTURE_2jo7\| PDB=2jo7 \| SCENE= }}~~	+	The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking.,Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:18035372<ref>PMID:18035372</ref>

-	~~===Solution structure~~ of the ~~adhesion protein Bd37 from Babesia divergens===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18035372}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2jo7]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].~~	+	</StructureSection>
	[[Category: Babesia divergens]]		[[Category: Babesia divergens]]
	[[Category: Arold, S.]]		[[Category: Arold, S.]]

OCA: Protected "2jo7" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:13:50 GMT

Protected "2jo7" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:13, 7 January 2013

OCA at 14:13, 7 January 2013

OCA — Mon, 07 Jan 2013 14:13:48 GMT

←Older revision		Revision as of 14:13, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jo7.png\|left\|200px]]		[[Image:2jo7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jo7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jo7\| PDB=2jo7 \| SCENE= }}		{{STRUCTURE_2jo7\| PDB=2jo7 \| SCENE= }}

	===Solution structure of the adhesion protein Bd37 from Babesia divergens===		===Solution structure of the adhesion protein Bd37 from Babesia divergens===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18035372}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18035372 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18035372}}		{{ABSTRACT_PUBMED_18035372}}

	==About this Structure==		==About this Structure==
-	~~2JO7 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].	+	[[2jo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].
-		+
-	~~==Reference==~~	+
-	The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking., Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C, J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18035372 18035372]	+
	[[Category: Babesia divergens]]		[[Category: Babesia divergens]]
-	[[Category: Single protein]]
	[[Category: Arold, S.]]		[[Category: Arold, S.]]
	[[Category: Auguin, D.]]		[[Category: Auguin, D.]]
Line 40:		Line 24:
	[[Category: Surface active protein]]		[[Category: Surface active protein]]
	[[Category: Surface antigen]]		[[Category: Surface antigen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:47 2008''

OCA at 15:48, 28 July 2008

OCA — Mon, 28 Jul 2008 15:48:48 GMT

←Older revision		Revision as of 15:48, 28 July 2008
Line 1:		Line 1:
-	[[Image:2jo7.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2jo7.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2jo7\| PDB=2jo7 \| SCENE= }}		{{STRUCTURE_2jo7\| PDB=2jo7 \| SCENE= }}

-	~~'''~~Solution structure of the adhesion protein Bd37 from Babesia divergens~~'''~~	+	===Solution structure of the adhesion protein Bd37 from Babesia divergens===


-	~~==Overview==~~	+	<!--
-	~~Babesia divergens is the Apicomplexa agent of the bovine babesiosis in Europe:~~ this ~~infection leads to growth and lactation decrease~~, ~~so that economical losses due~~ to ~~this parasite are sufficient to require~~ the ~~development of a vaccine. The major surface antigen of B. divergens has been described~~ as ~~a 37 kDa protein glycosyl phosphatidyl inositol (GPI)-anchored~~ at ~~the surface of the merozoite~~. ~~The immuno-prophylactic potential of Bd37 has been demonstrated, and we present here the high-resolution solution structure of the 27 kDa structured core of Bd37 (Delta-Bd37) using NMR spectroscopy~~. ~~A model for the whole protein has been obtained using additional small angle X-ray scattering (SAXS~~) ~~data. The knowledge of~~ the ~~3D structure of Bd37 allowed the precise epitope mapping of antibodies on its surface~~. ~~Interestingly, the geometry of Delta~~-~~Bd37 reveals an intriguing similarity with the exocyst subunit Exo84p C~~-terminal region, an eukaryotic protein that has a direct implication in vesicle trafficking. This strongly suggests that Apicomplexa have developed in parallel molecular machines similar in structure and function to the ones used for endo- and exocytosis in eukaryotic cells.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18035372}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18035372 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18035372}}

	==About this Structure==		==About this Structure==
-	2JO7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].	+	2JO7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA].

	==Reference==		==Reference==
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	[[Category: Surface active protein]]		[[Category: Surface active protein]]
	[[Category: Surface antigen]]		[[Category: Surface antigen]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:06:06 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:47 2008''