2jqd - Revision history

OCA at 19:04, 29 May 2024

OCA — Wed, 29 May 2024 19:04:31 GMT

←Older revision		Revision as of 19:04, 29 May 2024
Line 1:		Line 1:

	==Structure of the Leucine-Rich Repeat domain of LANP==		==Structure of the Leucine-Rich Repeat domain of LANP==
-	<StructureSection load='2jqd' size='340' side='right'caption='[[2jqd~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2jqd' size='340' side='right'caption='[[2jqd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Anp32a, Anp32, Lanp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [https://pdbe.org/2jqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [https://www.ebi.ac.uk/pdbsum/2jqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [https://pdbe.org/2jqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [https://www.ebi.ac.uk/pdbsum/2jqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AN32A_MOUSE AN32A_MOUSE]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:17557114</ref>	+	[https://www.uniprot.org/uniprot/AN32A_MOUSE AN32A_MOUSE] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:17557114</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Chiara, C de~~]]	+	[[Category: Pastore A]]
-	[[Category: Pastore, A]]	+	[[Category: De Chiara C]]
-	[[Category: ~~Apoptosis]]~~	+
-	~~[[Category: Cerebellar morphogenesis]]~~	+
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Lanp/anp32a]]~~	+
-	~~[[Category: Lrr domain]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Pp2a inhibitor]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Rna shuttling]]~~	+
-	~~[[Category: Transcriptional regulation]]~~	+
-	~~[[Category: Tumor suppression~~]]	+

OCA at 07:53, 7 April 2021

OCA — Wed, 07 Apr 2021 07:53:39 GMT

←Older revision		Revision as of 07:53, 7 April 2021
Line 1:		Line 1:

	==Structure of the Leucine-Rich Repeat domain of LANP==		==Structure of the Leucine-Rich Repeat domain of LANP==
-	<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2jqd' size='340' side='right'caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [~~http~~://pdbe.org/2jqd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jqd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [https://pdbe.org/2jqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [https://www.ebi.ac.uk/pdbsum/2jqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AN32A_MOUSE AN32A_MOUSE]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:17557114</ref>	+	[[https://www.uniprot.org/uniprot/AN32A_MOUSE AN32A_MOUSE]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:17557114</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Chiara, C de]]		[[Category: Chiara, C de]]

OCA at 07:14, 11 July 2018

OCA — Wed, 11 Jul 2018 07:14:49 GMT

←Older revision		Revision as of 07:14, 11 July 2018
Line 1:		Line 1:
		+
	==Structure of the Leucine-Rich Repeat domain of LANP==		==Structure of the Leucine-Rich Repeat domain of LANP==
	<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://pdbe.org/2jqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://pdbe.org/2jqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jqd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jqd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:01, 10 February 2016

OCA — Wed, 10 Feb 2016 07:01:33 GMT

←Older revision		Revision as of 07:01, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jqd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:30, 11 September 2015

OCA — Fri, 11 Sep 2015 06:30:08 GMT

←Older revision		Revision as of 06:30, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://pdbe.org/2jqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jqd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Chiara, C de]]		[[Category: Chiara, C de]]
	[[Category: Pastore, A]]		[[Category: Pastore, A]]

OCA at 12:36, 25 December 2014

OCA — Thu, 25 Dec 2014 12:36:12 GMT

←Older revision		Revision as of 12:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AN32A_MOUSE AN32A_MOUSE]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:17557114</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Chiara, C de.]]	+	[[Category: Chiara, C de]]
-	[[Category: Pastore, A.]]	+	[[Category: Pastore, A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cerebellar morphogenesis]]		[[Category: Cerebellar morphogenesis]]

OCA at 10:12, 30 September 2014

OCA — Tue, 30 Sep 2014 10:12:47 GMT

←Older revision		Revision as of 10:12, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jqd.~~png\|left~~\|200px]]	+	==Structure of the Leucine-Rich Repeat domain of LANP==
		+	<StructureSection load='2jqd' size='340' side='right' caption='[[2jqd]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Anp32a, Anp32, Lanp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jqd RCSB], [http://www.ebi.ac.uk/pdbsum/2jqd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jqd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The leucine-rich repeat acidic nuclear protein (Anp32a/LANP) belongs to a family of evolutionarily-conserved phosphoproteins involved in a complex network of protein-protein interactions. In an effort to understand the cellular role, we have investigated the mode of interaction of Anp32a with its partners. As a prerequisite, we solved the structure in solution of the evolutionarily conserved N-terminal leucine-rich repeat (LRR) domain and modeled its interactions with other proteins, taking PP2A as a paradigmatic example. The interaction between the Anp32a LRR domain and the AXH domain of ataxin-1 was probed experimentally. The two isolated and unmodified domains bind with very weak (millimolar) affinity, thus suggesting the necessity either for an additional partner (e.g. other regions of either or both proteins or a third molecule) or for a post-translational modification. Finally, we identified by two-hybrid screening a new partner of the LRR domain, i.e. the microtubule plus-end tracking protein Clip 170/Restin, known to regulate the dynamic properties of microtubules and to be associated with severe human pathologies.

-	~~{{STRUCTURE_2jqd\| PDB=2jqd \| SCENE= }}~~	+	Structural bases for recognition of Anp32/LANP proteins.,de Chiara C, Menon RP, Pastore A FEBS J. 2008 May;275(10):2548-60. Epub 2008 Apr 10. PMID:18410380<ref>PMID:18410380</ref>

-	~~===Structure~~ of the ~~Leucine-Rich Repeat domain of LANP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18410380}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jqd]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018410380<~~/~~ref~~><~~ref group="xtra">PMID:015895553</ref><ref group="xtra">PMID:017180445</ref><references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chiara, C de.]]		[[Category: Chiara, C de.]]

OCA at 13:16, 30 January 2013

OCA — Wed, 30 Jan 2013 13:16:14 GMT

←Older revision		Revision as of 13:16, 30 January 2013
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	[[Image:2jqd.png\|left\|200px]]		[[Image:2jqd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jqd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2jqd\| PDB=2jqd \| SCENE= }}		{{STRUCTURE_2jqd\| PDB=2jqd \| SCENE= }}

	===Structure of the Leucine-Rich Repeat domain of LANP===		===Structure of the Leucine-Rich Repeat domain of LANP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18410380}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18410380 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18410380}}		{{ABSTRACT_PUBMED_18410380}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18410380~~</ref><ref group="xtra">PMID:~~15895553~~</ref><ref group="xtra">PMID:~~17180445~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018410380</ref><ref group="xtra">PMID:015895553</ref><ref group="xtra">PMID:017180445</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chiara, C de.]]		[[Category: Chiara, C de.]]

OCA: Protected "2jqd" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 22:48:29 GMT

Protected "2jqd" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:48, 14 March 2011

OCA at 22:48, 14 March 2011

OCA — Mon, 14 Mar 2011 22:48:28 GMT

←Older revision		Revision as of 22:48, 14 March 2011
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-	{{Seed}}
	[[Image:2jqd.png\|left\|200px]]		[[Image:2jqd.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2JQD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA].	+	[[2jqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA].

	==Reference==		==Reference==
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	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]
	[[Category: Tumor suppression]]		[[Category: Tumor suppression]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:20:26 2009''