2jrj - Revision history

OCA at 10:11, 20 December 2023

OCA — Wed, 20 Dec 2023 10:11:52 GMT

←Older revision		Revision as of 10:11, 20 December 2023
Line 1:		Line 1:

	==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==		==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==
-	<StructureSection load='2jrj' size='340' side='right'caption='[[2jrj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jrj' size='340' side='right'caption='[[2jrj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RCHY1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [https://pdbe.org/2jrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [https://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrj ProSAT], [https://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [https://pdbe.org/2jrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [https://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrj ProSAT], [https://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>	+	[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Laister~~, R C~~]]	+	[[Category: Laister RC]]
-	[[Category: Lemak, A]]	+	[[Category: Lemak A]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sheng Y]]
-	[[Category: Sheng, Y]]	+	[[Category: Wu B]]
-	[[Category: Wu, B]]	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Ring domain]]~~	+
-	~~[[Category: Ubiquitin e3 ligase~~]]	+

OCA at 07:54, 7 April 2021

OCA — Wed, 07 Apr 2021 07:54:28 GMT

←Older revision		Revision as of 07:54, 7 April 2021
Line 1:		Line 1:

	==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==		==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==
-	<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jrj' size='340' side='right'caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [~~http~~://pdbe.org/2jrj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrj ProSAT], [~~http~~://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [https://pdbe.org/2jrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [https://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrj ProSAT], [https://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>	+	[[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Laister, R C]]		[[Category: Laister, R C]]

OCA at 06:46, 11 July 2018

OCA — Wed, 11 Jul 2018 06:46:09 GMT

←Older revision		Revision as of 06:46, 11 July 2018
Line 1:		Line 1:
		+
	==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==		==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==
	<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://pdbe.org/2jrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://pdbe.org/2jrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrj ProSAT], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:59, 9 February 2016

OCA — Tue, 09 Feb 2016 00:59:19 GMT

←Older revision		Revision as of 00:59, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jrj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:03, 10 September 2015

OCA — Thu, 10 Sep 2015 17:03:35 GMT

←Older revision		Revision as of 17:03, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://pdbe.org/2jrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jrj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Laister, R C]]		[[Category: Laister, R C]]

OCA at 15:21, 19 January 2015

OCA — Mon, 19 Jan 2015 15:21:02 GMT

←Older revision		Revision as of 15:21, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Laister, R C.]]	+	[[Category: Laister, R C]]
-	[[Category: Lemak, A.]]	+	[[Category: Lemak, A]]
-	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sheng, Y.]]	+	[[Category: Sheng, Y]]
-	[[Category: Wu, B.]]	+	[[Category: Wu, B]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Nesg]]		[[Category: Nesg]]
-	[[Category: ~~Northeast structural genomics consortium]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi-2~~]]	+
	[[Category: Ring domain]]		[[Category: Ring domain]]
-	[[Category: Structural genomic]]
	[[Category: Ubiquitin e3 ligase]]		[[Category: Ubiquitin e3 ligase]]

OCA at 08:40, 30 September 2014

OCA — Tue, 30 Sep 2014 08:40:35 GMT

←Older revision		Revision as of 08:40, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jrj.~~png~~\|~~left~~\|200px]]	+	==Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B==
		+	<StructureSection load='2jrj' size='340' side='right' caption='[[2jrj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCHY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrj RCSB], [http://www.ebi.ac.uk/pdbsum/2jrj PDBsum], [http://www.topsan.org/Proteins/NESGC/2jrj TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pirh2 (p53-induced RING-H2 domain protein; also known as Rchy1) is an E3 ubiquitin ligase involved in a negative-feedback loop with p53. Using NMR spectroscopy, we show that Pirh2 is a unique cysteine-rich protein comprising three modular domains. The protein binds nine zinc ions using a variety of zinc coordination schemes, including a RING domain and a left-handed beta-spiral in which three zinc ions align three consecutive small beta-sheets in an interleaved fashion. We show that Pirh2-p53 interaction is dependent on the C-terminal zinc binding module of Pirh2, which binds to the tetramerization domain of p53. As a result, Pirh2 preferentially ubiquitylates the tetrameric form of p53 in vitro and in vivo, suggesting that Pirh2 regulates protein turnover of the transcriptionally active form of p53.

-	~~{{STRUCTURE_2jrj\| PDB=2jrj \| SCENE= }}~~	+	Molecular basis of Pirh2-mediated p53 ubiquitylation.,Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH Nat Struct Mol Biol. 2008 Dec;15(12):1334-42. Epub 2008 Nov 30. PMID:19043414<ref>PMID:19043414</ref>

-	~~===Solution structure~~ of the ~~human Pirh2 RING-H2 domain~~. ~~Northeast Structural Genomics Consortium Target HT2B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19043414}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jrj]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019043414<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "2jrj" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:03:09 GMT

Protected "2jrj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:03, 7 January 2013

OCA at 11:03, 7 January 2013

OCA — Mon, 07 Jan 2013 11:03:06 GMT

←Older revision		Revision as of 11:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jrj.png\|left\|200px]]		[[Image:2jrj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jrj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jrj\| PDB=2jrj \| SCENE= }}		{{STRUCTURE_2jrj\| PDB=2jrj \| SCENE= }}

	===Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B===		===Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19043414}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19043414 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19043414}}		{{ABSTRACT_PUBMED_19043414}}

	==About this Structure==		==About this Structure==
-	~~2JRJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA].	+	[[2jrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19043414~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019043414</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 31:		Line 19:
	[[Category: Sheng, Y.]]		[[Category: Sheng, Y.]]
	[[Category: Wu, B.]]		[[Category: Wu, B.]]
		+	[[Category: Ligase]]
	[[Category: Nesg]]		[[Category: Nesg]]
	[[Category: Northeast structural genomics consortium]]		[[Category: Northeast structural genomics consortium]]
Line 38:		Line 27:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Ubiquitin e3 ligase]]		[[Category: Ubiquitin e3 ligase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:39:14 2009''

OCA at 17:39, 29 April 2009

OCA — Wed, 29 Apr 2009 17:39:15 GMT

←Older revision		Revision as of 17:39, 29 April 2009
Line 12:		Line 12:
	===Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B===		===Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19043414}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19043414 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19043414}}

	==About this Structure==		==About this Structure==
-	2JRJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA].	+	2JRJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19043414</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
-	[[Category: Laister, R.]]	+	[[Category: Laister, R C.]]
	[[Category: Lemak, A.]]		[[Category: Lemak, A.]]
	[[Category: NESG, Northeast Structural Genomics Consortium.]]		[[Category: NESG, Northeast Structural Genomics Consortium.]]
Line 30:		Line 39:
	[[Category: Ubiquitin e3 ligase]]		[[Category: Ubiquitin e3 ligase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 11~~:02:~~22 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 29 20:39:14 2009''