2jss - Revision history

OCA at 19:04, 29 May 2024

OCA — Wed, 29 May 2024 19:04:57 GMT

←Older revision		Revision as of 19:04, 29 May 2024
Line 1:		Line 1:

	==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==		==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==
-	<StructureSection load='2jss' size='340' side='right'caption='[[2jss~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2jss' size='340' side='right'caption='[[2jss]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1yfq\|1yfq]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [https://pdbe.org/2jss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [https://www.ebi.ac.uk/pdbsum/2jss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [https://pdbe.org/2jss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [https://www.ebi.ac.uk/pdbsum/2jss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~H2B1_YEAST H2B1_YEAST~~]~~] Core component of nucleosome~~. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:~~11973294~~</ref> <ref>PMID:~~12152067~~</ref> <ref>PMID:~~14752010~~</ref> <ref>PMID:~~15280549~~</ref> <ref>PMID:~~15652479~~</ref> <ref>PMID:~~15970663~~</ref> <ref>PMID:~~15632126~~</ref> <ref>PMID:~~15632065~~</ref> <ref>PMID:~~16598039~~</ref> [[https://www.uniprot.org/uniprot/~~CHZ1_YEAST CHZ1_YEAST~~]~~] Forms a chaperone-bound H2A~~.~~Z-H2B complex that acts~~ as a ~~source for SWR1~~ complex-~~dependent H2A to H2A.Z~~ histone ~~replacement in chromatin~~.<ref>PMID:~~17289584~~</ref>	+	[https://www.uniprot.org/uniprot/H2AZ_YEAST H2AZ_YEAST] Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received (PubMed:11000274, PubMed:11081628, PubMed:11090616, PubMed:11509669, PubMed:12628191, PubMed:14645854, PubMed:14690608, PubMed:15045029, PubMed:16239142, PubMed:16344463, PubMed:16543223). Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins (PubMed:16543222). Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes (PubMed:11509669). Involved in chromosome stability (PubMed:15353583). Required to target MPS3 to the inner membrane of the nuclear envelope (PubMed:21518795).<ref>PMID:11000274</ref> <ref>PMID:11081628</ref> <ref>PMID:11090616</ref> <ref>PMID:11509669</ref> <ref>PMID:12628191</ref> <ref>PMID:14645854</ref> <ref>PMID:14690608</ref> <ref>PMID:15045029</ref> <ref>PMID:15353583</ref> <ref>PMID:16239142</ref> <ref>PMID:16344463</ref> <ref>PMID:16543222</ref> <ref>PMID:16543223</ref> <ref>PMID:21518795</ref> [https://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bai, Y]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Feng, H]]	+	[[Category: Bai Y]]
-	[[Category: Freedberg~~, D I~~]]	+	[[Category: Feng H]]
-	[[Category: Hansen~~, D F~~]]	+	[[Category: Freedberg DI]]
-	[[Category: Kato, H]]	+	[[Category: Hansen DF]]
-	[[Category: Kay~~, L E~~]]	+	[[Category: Kato H]]
-	[[Category: Luk, E]]	+	[[Category: Kay LE]]
-	[[Category: Wu, C]]	+	[[Category: Luk E]]
-	[[Category: Zhou, Z]]	+	[[Category: Wu C]]
-	~~[[Category: Chaperone-nuclear protein complex]]~~	+	[[Category: Zhou Z]]
-	~~[[Category: Chaperone-structural protein complex]]~~	+
-	~~[[Category: Histone-chaperone complex]]~~	+
-	~~[[Category: Intrinsically unfolded protein~~]]	+

OCA at 06:10, 18 August 2021

OCA — Wed, 18 Aug 2021 06:10:14 GMT

←Older revision		Revision as of 06:10, 18 August 2021
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	<StructureSection load='2jss' size='340' side='right'caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jss' size='340' side='right'caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yfq\|1yfq]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yfq\|1yfq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~4932 Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [https://pdbe.org/2jss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [https://www.ebi.ac.uk/pdbsum/2jss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [https://pdbe.org/2jss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [https://www.ebi.ac.uk/pdbsum/2jss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>
	</table>		</table>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Bai, Y]]		[[Category: Bai, Y]]
	[[Category: Feng, H]]		[[Category: Feng, H]]

OCA at 07:55, 7 April 2021

OCA — Wed, 07 Apr 2021 07:55:23 GMT

←Older revision		Revision as of 07:55, 7 April 2021
Line 1:		Line 1:

	==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==		==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==
-	<StructureSection load='2jss' size='340' side='right' caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2jss' size='340' side='right'caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yfq\|1yfq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [~~http~~://pdbe.org/2jss PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jss PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [https://pdbe.org/2jss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [https://www.ebi.ac.uk/pdbsum/2jss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[~~http~~://www.uniprot.org/uniprot/CHZ1_YEAST CHZ1_YEAST]] Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.<ref>PMID:17289584</ref>	+	[[https://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[https://www.uniprot.org/uniprot/CHZ1_YEAST CHZ1_YEAST]] Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.<ref>PMID:17289584</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bai, Y]]		[[Category: Bai, Y]]

OCA at 10:39, 18 July 2018

OCA — Wed, 18 Jul 2018 10:39:37 GMT

←Older revision		Revision as of 10:39, 18 July 2018
Line 1:		Line 1:
		+
	==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==		==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==
	<StructureSection load='2jss' size='340' side='right' caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jss' size='340' side='right' caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [http://pdbe.org/2jss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [http://www.ebi.ac.uk/pdbsum/2jss PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [http://pdbe.org/2jss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [http://www.ebi.ac.uk/pdbsum/2jss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jss ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jss_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jss_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jss ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:02, 11 September 2015

OCA — Fri, 11 Sep 2015 16:02:40 GMT

←Older revision		Revision as of 16:02, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [http://www.ebi.ac.uk/pdbsum/2jss PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [http://pdbe.org/2jss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [http://www.ebi.ac.uk/pdbsum/2jss PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref>	+	[[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/CHZ1_YEAST CHZ1_YEAST]] Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.<ref>PMID:17289584</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jss" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:45, 25 December 2014

OCA — Thu, 25 Dec 2014 18:45:21 GMT

←Older revision		Revision as of 18:45, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~2jss.~~png~~\|~~left~~\|200px]]	+	==NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B==
		+	<StructureSection load='2jss' size='340' side='right' caption='[[2jss]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSS FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yfq\|1yfq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HTB1, H2B1, SPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jss OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jss RCSB], [http://www.ebi.ac.uk/pdbsum/2jss PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jss_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.

-	~~{{STRUCTURE_2jss\| PDB=2jss \| SCENE= }}~~	+	NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.,Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y Nat Struct Mol Biol. 2008 Aug;15(8):868-9. Epub 2008 Jul 20. PMID:18641662<ref>PMID:18641662</ref>

-	~~===NMR structure~~ of ~~chaperone Chz1 complexed with histone H2A~~.~~Z-H2B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18641662}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jss]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].~~	+

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018641662<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Bai, Y.]]	+	[[Category: Bai, Y]]
-	[[Category: Feng, H.]]	+	[[Category: Feng, H]]
-	[[Category: Freedberg, D I.]]	+	[[Category: Freedberg, D I]]
-	[[Category: Hansen, D F.]]	+	[[Category: Hansen, D F]]
-	[[Category: Kato, H.]]	+	[[Category: Kato, H]]
-	[[Category: Kay, L E.]]	+	[[Category: Kay, L E]]
-	[[Category: Luk, E.]]	+	[[Category: Luk, E]]
-	[[Category: Wu, C.]]	+	[[Category: Wu, C]]
-	[[Category: Zhou, Z.]]	+	[[Category: Zhou, Z]]
	[[Category: Chaperone-nuclear protein complex]]		[[Category: Chaperone-nuclear protein complex]]
	[[Category: Chaperone-structural protein complex]]		[[Category: Chaperone-structural protein complex]]
	[[Category: Histone-chaperone complex]]		[[Category: Histone-chaperone complex]]
	[[Category: Intrinsically unfolded protein]]		[[Category: Intrinsically unfolded protein]]

OCA at 20:08, 20 October 2012

OCA — Sat, 20 Oct 2012 20:08:45 GMT

←Older revision		Revision as of 20:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jss]] is a 2 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].	+	[[2jss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].

	==See Also==		==See Also==

OCA: Protected "2jss" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 09:33:18 GMT

Protected "2jss" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 27 July 2012

OCA at 09:33, 27 July 2012

OCA — Fri, 27 Jul 2012 09:33:16 GMT

←Older revision		Revision as of 09:33, 27 July 2012
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-	{{Seed}}
	[[Image:2jss.png\|left\|200px]]		[[Image:2jss.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jss", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jss\| PDB=2jss \| SCENE= }}		{{STRUCTURE_2jss\| PDB=2jss \| SCENE= }}

	===NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B===		===NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18641662}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18641662 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18641662}}		{{ABSTRACT_PUBMED_18641662}}

	==About this Structure==		==About this Structure==
-	~~2JSS~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].	+	[[2jss]] is a 2 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].
		+
		+	==See Also==
		+	*[[Histone\|Histone]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18641662~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018641662</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bai, Y.]]		[[Category: Bai, Y.]]
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	[[Category: Wu, C.]]		[[Category: Wu, C.]]
	[[Category: Zhou, Z.]]		[[Category: Zhou, Z.]]
-	[[Category: Chaperone/nuclear protein complex]]	+	[[Category: Chaperone-nuclear protein complex]]
-	[[Category: Chaperone/structural protein complex]]	+	[[Category: Chaperone-structural protein complex]]
-	[[Category: Histone/chaperone complex]]	+	[[Category: Histone-chaperone complex]]
	[[Category: Intrinsically unfolded protein]]		[[Category: Intrinsically unfolded protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:54:16 2009''

OCA at 00:54, 18 February 2009

OCA — Wed, 18 Feb 2009 00:54:17 GMT

←Older revision		Revision as of 00:54, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JSS is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].	+	2JSS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSS OCA].

	==Reference==		==Reference==
-	NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B., Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y, Nat Struct Mol Biol. 2008 Aug;15(8):868-9. Epub 2008 Jul 20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18641662 18641662]~~	+	<ref group="xtra">PMID:18641662</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bai, Y.]]		[[Category: Bai, Y.]]
Line 40:		Line 39:
	[[Category: Intrinsically unfolded protein]]		[[Category: Intrinsically unfolded protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 20 11~~:27:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:54:16 2009''