2jsz - Revision history

OCA at 19:05, 29 May 2024

OCA — Wed, 29 May 2024 19:05:03 GMT

←Older revision		Revision as of 19:05, 29 May 2024
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	==Solution structure of Tpx in the reduced state==		==Solution structure of Tpx in the reduced state==
-	<StructureSection load='2jsz' size='340' side='right'caption='[[2jsz~~]], [[NMR_Ensembles_of_Models \| 21 NMR models~~]]' scene=''>	+	<StructureSection load='2jsz' size='340' side='right'caption='[[2jsz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>tpx, ytgI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1423 Bacillus subtilis])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [https://pdbe.org/2jsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [https://www.ebi.ac.uk/pdbsum/2jsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [https://pdbe.org/2jsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [https://www.ebi.ac.uk/pdbsum/2jsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TPX_BACSU TPX_BACSU]] Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).[HAMAP-Rule:MF_00269]	+	[https://www.uniprot.org/uniprot/TPX_BACSU TPX_BACSU] Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).[HAMAP-Rule:MF_00269]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jin, C]]	+	[[Category: Jin C]]
-	[[Category: Lu, J]]	+	[[Category: Lu J]]
-	[[Category: Yang, F]]	+	[[Category: Yang F]]
-	~~[[Category: Antioxidant]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxidase]]~~	+
-	~~[[Category: Solution structure~~]]	+

OCA at 07:55, 7 April 2021

OCA — Wed, 07 Apr 2021 07:55:41 GMT

←Older revision		Revision as of 07:55, 7 April 2021
Line 1:		Line 1:

	==Solution structure of Tpx in the reduced state==		==Solution structure of Tpx in the reduced state==
-	<StructureSection load='2jsz' size='340' side='right' caption='[[2jsz]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>	+	<StructureSection load='2jsz' size='340' side='right'caption='[[2jsz]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [~~http~~://pdbe.org/2jsz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jsz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [https://pdbe.org/2jsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [https://www.ebi.ac.uk/pdbsum/2jsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TPX_BACSU TPX_BACSU]] Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).[HAMAP-Rule:MF_00269]	+	[[https://www.uniprot.org/uniprot/TPX_BACSU TPX_BACSU]] Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).[HAMAP-Rule:MF_00269]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
		+	[[Category: Large Structures]]
	[[Category: Jin, C]]		[[Category: Jin, C]]
	[[Category: Lu, J]]		[[Category: Lu, J]]

OCA at 10:08, 18 July 2018

OCA — Wed, 18 Jul 2018 10:08:23 GMT

←Older revision		Revision as of 10:08, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of Tpx in the reduced state==		==Solution structure of Tpx in the reduced state==
	<StructureSection load='2jsz' size='340' side='right' caption='[[2jsz]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>		<StructureSection load='2jsz' size='340' side='right' caption='[[2jsz]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://pdbe.org/2jsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://pdbe.org/2jsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jsz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:46, 11 September 2015

OCA — Fri, 11 Sep 2015 22:46:55 GMT

←Older revision		Revision as of 22:46, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://pdbe.org/2jsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jsz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:27, 25 December 2014

OCA — Thu, 25 Dec 2014 20:27:51 GMT

←Older revision		Revision as of 20:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TPX_BACSU TPX_BACSU]] Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity).[HAMAP-Rule:MF_00269]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Jin, C.]]	+	[[Category: Jin, C]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
-	[[Category: Yang, F.]]	+	[[Category: Yang, F]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Solution structure]]		[[Category: Solution structure]]

OCA at 10:21, 30 September 2014

OCA — Tue, 30 Sep 2014 10:21:38 GMT

←Older revision		Revision as of 10:21, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jsz.~~png\|left~~\|200px]]	+	==Solution structure of Tpx in the reduced state==
		+	<StructureSection load='2jsz' size='340' side='right' caption='[[2jsz]], [[NMR_Ensembles_of_Models \| 21 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsz RCSB], [http://www.ebi.ac.uk/pdbsum/2jsz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial thiol peroxidase (Tpx) is the periplasmic antioxidant enzyme widely distributed in most bacterial species, which catalyzes the reduction of lipid hydroperoxide in vivo. Tpx belongs to the atypical 2-Cys peroxiredoxin (Prx) family and utilizes two active cysteine residues during the redox reaction. Although several crystal structures of Tpx are available, no pair of the redox structures reported thus far. Therefore, the conformational changes coupled to the catalytic reaction remain unclear. Herein, we report the solution structures of Bacillus subtilis Tpx in both the reduced and oxidized forms, the first pair of Tpx structures. The overall structures of both forms are very similar, however, significant differences at the active regions around the C(P) and C(R) residues were observed. In particular, a helix-to-coil transition was observed at the C(R) region between the two forms. Our study reveals a dynamic picture of the conformational switch coupled to the redox reaction, thus provides further insights in understanding the catalytic mechanism of bacterial Tpx.

-	~~{{STRUCTURE_2jsz\| PDB=2jsz \| SCENE= }}~~	+	Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase.,Lu J, Yang F, Li Y, Zhang X, Xia B, Jin C Biochem Biophys Res Commun. 2008 Aug 29;373(3):414-8. Epub 2008 Jun 25. PMID:18588855<ref>PMID:18588855</ref>

-	~~===Solution structure~~ of ~~Tpx in~~ the ~~reduced state===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18588855}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jsz]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018588855<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Jin, C.]]		[[Category: Jin, C.]]

OCA: Protected "2jsz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:11:45 GMT

Protected "2jsz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:11, 7 January 2013

OCA at 12:11, 7 January 2013

OCA — Mon, 07 Jan 2013 12:11:42 GMT

←Older revision		Revision as of 12:11, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jsz.png\|left\|200px]]		[[Image:2jsz.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2jsz\| PDB=2jsz \| SCENE= }}		{{STRUCTURE_2jsz\| PDB=2jsz \| SCENE= }}

	===Solution structure of Tpx in the reduced state===		===Solution structure of Tpx in the reduced state===

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	{{ABSTRACT_PUBMED_18588855}}		{{ABSTRACT_PUBMED_18588855}}

	==About this Structure==		==About this Structure==
-	~~2JSZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA].	+	[[2jsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18588855~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018588855</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Jin, C.]]		[[Category: Jin, C.]]
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	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Solution structure]]		[[Category: Solution structure]]
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OCA at 04:14, 18 February 2009

OCA — Wed, 18 Feb 2009 04:14:07 GMT

←Older revision		Revision as of 04:14, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2JSZ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA].	+	2JSZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSZ OCA].

	==Reference==		==Reference==
-	Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase., Lu J, Yang F, Li Y, Zhang X, Xia B, Jin C, Biochem Biophys Res Commun. 2008 Aug 29;373(3):414-8. Epub 2008 Jun 25. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18588855 18588855]~~	+	<ref group="xtra">PMID:18588855</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Single protein]]
	[[Category: Jin, C.]]		[[Category: Jin, C.]]
	[[Category: Lu, J.]]		[[Category: Lu, J.]]
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	[[Category: Solution structure]]		[[Category: Solution structure]]

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OCA at 09:56, 29 July 2008

OCA — Tue, 29 Jul 2008 09:56:36 GMT

←Older revision		Revision as of 09:56, 29 July 2008
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-	[[Image:2jsz.~~jpg~~\|left\|200px]]	+	[[Image:2jsz.png\|left\|200px]]

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