2jtc - Revision history

OCA at 19:05, 29 May 2024

OCA — Wed, 29 May 2024 19:05:16 GMT

←Older revision		Revision as of 19:05, 29 May 2024
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	==3D structure and backbone dynamics of SPE B==		==3D structure and backbone dynamics of SPE B==
-	<StructureSection load='2jtc' size='340' side='right'caption='[[2jtc~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jtc' size='340' side='right'caption='[[2jtc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strp1 Strp1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTC FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>speB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=301447 STRP1])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [https://pdbe.org/2jtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [https://www.ebi.ac.uk/pdbsum/2jtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [https://pdbe.org/2jtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [https://www.ebi.ac.uk/pdbsum/2jtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPEB_STRP1 SPEB_STRP1]] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:10456871</ref>	+	[https://www.uniprot.org/uniprot/SPEB_STRP1 SPEB_STRP1] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:10456871</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Streptopain]]~~	+	[[Category: Streptococcus pyogenes serotype M1]]
-	~~[[Category: Strp1~~]]	+	[[Category: Chen C]]
-	[[Category: Chen, C]]	+	[[Category: Chuang W]]
-	[[Category: Chuang, W]]	+	[[Category: Houng H]]
-	[[Category: Houng, H]]	+	[[Category: Wang C]]
-	[[Category: Wang, C]]	+	[[Category: Wang P]]
-	[[Category: Wang, P]]	+
-	~~[[Category: Dynamic]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Loop movement]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Virulence]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 07:56, 7 April 2021

OCA — Wed, 07 Apr 2021 07:56:08 GMT

←Older revision		Revision as of 07:56, 7 April 2021
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	==3D structure and backbone dynamics of SPE B==		==3D structure and backbone dynamics of SPE B==
-	<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jtc' size='340' side='right'caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strp1 Strp1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JTC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strp1 Strp1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTC FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [~~http~~://pdbe.org/2jtc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jtc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [https://pdbe.org/2jtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [https://www.ebi.ac.uk/pdbsum/2jtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPEB_STRP1 SPEB_STRP1]] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:10456871</ref>	+	[[https://www.uniprot.org/uniprot/SPEB_STRP1 SPEB_STRP1]] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:10456871</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Exotoxin\|Exotoxin]]	+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
	[[Category: Strp1]]		[[Category: Strp1]]

OCA at 10:47, 18 July 2018

OCA — Wed, 18 Jul 2018 10:47:05 GMT

←Older revision		Revision as of 10:47, 18 July 2018
Line 1:		Line 1:
		+
	==3D structure and backbone dynamics of SPE B==		==3D structure and backbone dynamics of SPE B==
	<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://pdbe.org/2jtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://pdbe.org/2jtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:03, 7 February 2016

OCA — Sun, 07 Feb 2016 15:03:19 GMT

←Older revision		Revision as of 15:03, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:37, 10 September 2015

OCA — Thu, 10 Sep 2015 02:37:29 GMT

←Older revision		Revision as of 02:37, 10 September 2015
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	<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp1 Strp1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTC FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 ~~Streptococcus pyogenes serotype M1~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://pdbe.org/2jtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jtc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus pyogenes serotype m1]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
		+	[[Category: Strp1]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Chuang, W]]		[[Category: Chuang, W]]

OCA at 16:06, 24 December 2014

OCA — Wed, 24 Dec 2014 16:06:12 GMT

←Older revision		Revision as of 16:06, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 Streptococcus pyogenes serotype M1])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 Streptococcus pyogenes serotype M1])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPEB_STRP1 SPEB_STRP1]] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:10456871</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Streptococcus pyogenes serotype m1]]		[[Category: Streptococcus pyogenes serotype m1]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
-	[[Category: Chen, C.]]	+	[[Category: Chen, C]]
-	[[Category: Chuang, W.]]	+	[[Category: Chuang, W]]
-	[[Category: Houng, H.]]	+	[[Category: Houng, H]]
-	[[Category: Wang, C.]]	+	[[Category: Wang, C]]
-	[[Category: Wang, P.]]	+	[[Category: Wang, P]]
	[[Category: Dynamic]]		[[Category: Dynamic]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 44:		Line 46:
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
-	[[Category: Streptopain]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Virulence]]		[[Category: Virulence]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 09:32, 30 September 2014

OCA — Tue, 30 Sep 2014 09:32:34 GMT

←Older revision		Revision as of 09:32, 30 September 2014
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-	[[~~Image~~:2jtc.~~png\|left~~\|200px]]	+	==3D structure and backbone dynamics of SPE B==
		+	<StructureSection load='2jtc' size='340' side='right' caption='[[2jtc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">speB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 Streptococcus pyogenes serotype M1])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Streptopain Streptopain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.10 3.4.22.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtc RCSB], [http://www.ebi.ac.uk/pdbsum/2jtc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcal pyrogenic exotoxin B (SPE B) is a cysteine protease expressed by Streptococcus pyogenes. The D9N, G163S, G163S/A172S, and G239D mutant proteins were expressed to study the effect of the allelic variants on their protease activity. In contrast to other mutants, the G239D mutant was approximately 12-fold less active. The Gly-239 residue is located within the C-terminal S230-G239 region, which cannot be observed in the x-ray structure. The three-dimensional structure and backbone dynamics of the 28-kDa mature SPE B (mSPE B) were determined. Unlike the x-ray structure of the 40-kDa zymogen SPE B (proSPE B), we observed the interactions between the C-terminal loop and the active site residues in mSPE B. The structural differences between mSPE B and proSPE B were the conformation of the C-terminal loop and the orientation of the catalytic His-195 residue, suggesting that activation and inactivation of SPE B is involved in the His-195 side-chain rotation. Dynamics analysis of mSPE B and the mSPE B/inhibitor complexes showed that the catalytic and C-terminal loops were the most flexible regions with low order parameter values of 0.5 to 0.8 and exhibited the motion on the ps/ns timescale. These findings suggest that the flexible C-terminal loop of SPE B may play an important role in controlling the substrate binding, resulting in its broad substrate specificity.

-	~~{{STRUCTURE_2jtc\| PDB=2jtc \| SCENE= }}~~	+	Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity.,Wang CC, Houng HC, Chen CL, Wang PJ, Kuo CF, Lin YS, Wu JJ, Lin MT, Liu CC, Huang W, Chuang WJ J Biol Chem. 2009 Apr 17;284(16):10957-67. Epub 2009 Feb 23. PMID:19237546<ref>PMID:19237546</ref>

-	~~===3D structure and backbone dynamics~~ of ~~SPE B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19237546}}~~	+	==See Also==
-		+	*[[Exotoxin\|Exotoxin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2jtc~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019237546<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptococcus pyogenes serotype m1]]		[[Category: Streptococcus pyogenes serotype m1]]
	[[Category: Streptopain]]		[[Category: Streptopain]]

OCA: Protected "2jtc" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:26:32 GMT

Protected "2jtc" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:26, 7 January 2013

OCA at 14:26, 7 January 2013

OCA — Mon, 07 Jan 2013 14:26:29 GMT

←Older revision		Revision as of 14:26, 7 January 2013
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-	{{Seed}}
	[[Image:2jtc.png\|left\|200px]]		[[Image:2jtc.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2jtc\| PDB=2jtc \| SCENE= }}		{{STRUCTURE_2jtc\| PDB=2jtc \| SCENE= }}

	===3D structure and backbone dynamics of SPE B===		===3D structure and backbone dynamics of SPE B===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19237546}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19237546 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19237546}}		{{ABSTRACT_PUBMED_19237546}}

	==About this Structure==		==About this Structure==
-	~~2JTC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA].	+	[[2jtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19237546~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019237546</ref><references group="xtra"/>
	[[Category: Streptococcus pyogenes serotype m1]]		[[Category: Streptococcus pyogenes serotype m1]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Loop movement]]		[[Category: Loop movement]]
-	[[Category: Nmr]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
-	[[Category: Structure]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Virulence]]		[[Category: Virulence]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 21:01:41 2009''

OCA at 18:01, 22 July 2009

OCA — Wed, 22 Jul 2009 18:01:45 GMT

←Older revision		Revision as of 18:01, 22 July 2009
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	===3D structure and backbone dynamics of SPE B===		===3D structure and backbone dynamics of SPE B===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19237546}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19237546 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19237546}}

	==About this Structure==		==About this Structure==
	2JTC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA].		2JTC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19237546</ref><references group="xtra"/>
	[[Category: Streptococcus pyogenes serotype m1]]		[[Category: Streptococcus pyogenes serotype m1]]
	[[Category: Streptopain]]		[[Category: Streptopain]]
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	[[Category: Zymogen]]		[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Feb 16 14~~:39:10 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 21:01:41 2009''