2juo - Revision history

OCA at 09:42, 9 May 2024

OCA — Thu, 09 May 2024 09:42:38 GMT

←Older revision		Revision as of 09:42, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:37, 14 June 2023

OCA — Wed, 14 Jun 2023 08:37:23 GMT

←Older revision		Revision as of 08:37, 14 June 2023
Line 1:		Line 1:

	==GABPa OST domain==		==GABPa OST domain==
-	<StructureSection load='2juo' size='340' side='right'caption='[[2juo~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2juo' size='340' side='right'caption='[[2juo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE]] Transcription factor capable of interacting with purine rich repeats (GA repeats).	+	[https://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE] Transcription factor capable of interacting with purine rich repeats (GA repeats).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Graves~~, B J~~]]	+	[[Category: Graves BJ]]
-	[[Category: Kang, H]]	+	[[Category: Kang H]]
-	[[Category: Mackereth~~, C D~~]]	+	[[Category: Mackereth CD]]
-	[[Category: McIntosh~~, L P~~]]	+	[[Category: McIntosh LP]]
-	[[Category: Nelson~~, M L~~]]	+	[[Category: Nelson ML]]
-	[[Category: Schaerpf, M]]	+	[[Category: Schaerpf M]]
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Ga-binding protein]]~~	+
-	~~[[Category: Nmr ensemble]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Ost]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Ubiquitin~~]]	+

OCA at 13:25, 24 November 2021

OCA — Wed, 24 Nov 2021 13:25:43 GMT

←Older revision		Revision as of 13:25, 24 November 2021
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	<StructureSection load='2juo' size='340' side='right'caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2juo' size='340' side='right'caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [~~http~~://pdbe.org/2juo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2juo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [https://pdbe.org/2juo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [https://www.ebi.ac.uk/pdbsum/2juo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE]] Transcription factor capable of interacting with purine rich repeats (GA repeats).	+	[[https://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE]] Transcription factor capable of interacting with purine rich repeats (GA repeats).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:50, 19 February 2020

OCA — Wed, 19 Feb 2020 06:50:26 GMT

←Older revision		Revision as of 06:50, 19 February 2020
Line 1:		Line 1:

	==GABPa OST domain==		==GABPa OST domain==
-	<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2juo' size='340' side='right'caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Graves, B J]]		[[Category: Graves, B J]]

OCA at 10:33, 18 July 2018

OCA — Wed, 18 Jul 2018 10:33:32 GMT

←Older revision		Revision as of 10:33, 18 July 2018
Line 1:		Line 1:
		+
	==GABPa OST domain==		==GABPa OST domain==
	<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://pdbe.org/2juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://pdbe.org/2juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2juo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:40, 9 February 2016

OCA — Tue, 09 Feb 2016 02:40:33 GMT

←Older revision		Revision as of 02:40, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2juo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:48, 10 September 2015

OCA — Thu, 10 Sep 2015 17:48:48 GMT

←Older revision		Revision as of 17:48, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://pdbe.org/2juo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2juo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Graves, B J]]		[[Category: Graves, B J]]
	[[Category: Kang, H]]		[[Category: Kang, H]]

OCA at 03:50, 25 December 2014

OCA — Thu, 25 Dec 2014 03:50:57 GMT

←Older revision		Revision as of 03:50, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE]] Transcription factor capable of interacting with purine rich repeats (GA repeats).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Graves, B J.]]	+	[[Category: Graves, B J]]
-	[[Category: Kang, H.]]	+	[[Category: Kang, H]]
-	[[Category: Mackereth, C D.]]	+	[[Category: Mackereth, C D]]
-	[[Category: McIntosh, L P.]]	+	[[Category: McIntosh, L P]]
-	[[Category: Nelson, M L.]]	+	[[Category: Nelson, M L]]
-	[[Category: Schaerpf, M.]]	+	[[Category: Schaerpf, M]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Ga-binding protein]]		[[Category: Ga-binding protein]]

OCA at 09:26, 30 September 2014

OCA — Tue, 30 Sep 2014 09:26:28 GMT

←Older revision		Revision as of 09:26, 30 September 2014
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-	[[~~Image~~:2juo.~~png\|left~~\|200px]]	+	==GABPa OST domain==
		+	<StructureSection load='2juo' size='340' side='right' caption='[[2juo]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2juo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabpa, E4tf1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juo RCSB], [http://www.ebi.ac.uk/pdbsum/2juo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2juo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Using NMR spectroscopy, we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35-121) of the ETS family transcription factor GABP alpha. The monomeric domain folds as a five-stranded beta-sheet crossed by a distorted helix. Although globally resembling ubiquitin, the GABP alpha fragment differs in its secondary structure topology and thus appears to represent a new protein fold that we term the OST (On-SighT) domain. The surface of the GABP alpha OST domain contains two predominant clusters of negatively-charged residues suggestive of electrostatically driven interactions with positively-charged partner proteins. Following a best-candidate approach to identify such a partner, we demonstrated through NMR-monitored titrations and glutathione S-transferase pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.

-	~~{{STRUCTURE_2juo\| PDB=2juo \| SCENE= }}~~	+	Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.,Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP J Mol Biol. 2008 Mar 28;377(3):636-46. Epub 2008 Jan 30. PMID:18295234<ref>PMID:18295234</ref>

-	~~===GABPa OST domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18295234}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2juo]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018295234<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Graves, B J.]]		[[Category: Graves, B J.]]

OCA: Protected "2juo" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:42:09 GMT

Protected "2juo" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:42, 7 January 2013