2jwq - Revision history

OCA at 12:49, 20 December 2023

OCA — Wed, 20 Dec 2023 12:49:00 GMT

←Older revision		Revision as of 12:49, 20 December 2023
Line 1:		Line 1:

	==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==		==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==
-	<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [https://pdbe.org/2jwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [https://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [https://pdbe.org/2jwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [https://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guittat, L]]	+	[[Category: Guittat L]]
-	[[Category: Hounsou, C]]	+	[[Category: Hounsou C]]
-	[[Category: Jourdan, M]]	+	[[Category: Jourdan M]]
-	[[Category: Mergny~~, J L~~]]	+	[[Category: Mergny JL]]
-	[[Category: Monchaud, D]]	+	[[Category: Monchaud D]]
-	[[Category: Saettel, N]]	+	[[Category: Saettel N]]
-	[[Category: Teulade-Fichou, M]]	+	[[Category: Teulade-Fichou M]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G-quadruplex]]~~	+
-	~~[[Category: Quinacridine]]~~	+
-	~~[[Category: Telomerase inhibitor~~]]	+

OCA at 07:29, 27 January 2022

OCA — Thu, 27 Jan 2022 07:29:47 GMT

←Older revision		Revision as of 07:29, 27 January 2022
Line 3:		Line 3:
	<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [~~http~~://pdbe.org/2jwq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [https://pdbe.org/2jwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [https://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:29, 22 April 2020

OCA — Wed, 22 Apr 2020 06:29:14 GMT

←Older revision		Revision as of 06:29, 22 April 2020
Line 1:		Line 1:

	==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==		==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==
-	<StructureSection load='2jwq' size='340' side='right' caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://pdbe.org/2jwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://pdbe.org/2jwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Guittat, L]]		[[Category: Guittat, L]]
	[[Category: Hounsou, C]]		[[Category: Hounsou, C]]

OCA at 10:09, 18 July 2018

OCA — Wed, 18 Jul 2018 10:09:44 GMT

←Older revision		Revision as of 10:09, 18 July 2018
Line 1:		Line 1:
		+
	==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==		==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==
	<StructureSection load='2jwq' size='340' side='right' caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2jwq' size='340' side='right' caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://pdbe.org/2jwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://pdbe.org/2jwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:48, 10 September 2015

OCA — Thu, 10 Sep 2015 06:48:17 GMT

←Older revision		Revision as of 06:48, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://pdbe.org/2jwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jwq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:51, 22 December 2014

OCA — Mon, 22 Dec 2014 04:51:00 GMT

←Older revision		Revision as of 04:51, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guittat, L.]]	+	[[Category: Guittat, L]]
-	[[Category: Hounsou, C.]]	+	[[Category: Hounsou, C]]
-	[[Category: Jourdan, M.]]	+	[[Category: Jourdan, M]]
-	[[Category: Mergny, J L.]]	+	[[Category: Mergny, J L]]
-	[[Category: Monchaud, D.]]	+	[[Category: Monchaud, D]]
-	[[Category: Saettel, N.]]	+	[[Category: Saettel, N]]
-	[[Category: Teulade-Fichou, M.]]	+	[[Category: Teulade-Fichou, M]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: G-quadruplex]]		[[Category: G-quadruplex]]
	[[Category: Quinacridine]]		[[Category: Quinacridine]]
	[[Category: Telomerase inhibitor]]		[[Category: Telomerase inhibitor]]

OCA at 06:47, 9 June 2014

OCA — Mon, 09 Jun 2014 06:47:05 GMT

←Older revision		Revision as of 06:47, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~2jwq.~~png~~\|~~left\|200px~~]]	+	==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==
		+	<StructureSection load='2jwq' size='340' side='right' caption='[[2jwq]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.

-	~~{{STRUCTURE_2jwq\| PDB=2jwq \| SCENE= }}~~	+	G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study.,Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP ChemMedChem. 2007 May;2(5):655-66. PMID:17385760<ref>PMID:17385760</ref>

-	~~===G-quadruplex recognition by quinacridines: a SAR~~, ~~NMR and Biological study===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17385760}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jwq]] is~~ a ~~4 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2JWQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017385760<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Guittat, L.]]		[[Category: Guittat, L.]]
	[[Category: Hounsou, C.]]		[[Category: Hounsou, C.]]

OCA: Protected "2jwq" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 14:42:28 GMT

Protected "2jwq" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:42, 14 August 2012

OCA at 14:42, 14 August 2012

OCA — Tue, 14 Aug 2012 14:42:26 GMT

←Older revision		Revision as of 14:42, 14 August 2012
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-	{{Seed}}
	[[Image:2jwq.png\|left\|200px]]		[[Image:2jwq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jwq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jwq\| PDB=2jwq \| SCENE= }}		{{STRUCTURE_2jwq\| PDB=2jwq \| SCENE= }}

	===G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study===		===G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17385760}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17385760 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17385760}}		{{ABSTRACT_PUBMED_17385760}}

	==About this Structure==		==About this Structure==
-	~~2JWQ is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].	+	[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].

	==Reference==		==Reference==
-	~~G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17385760 17385760]~~	+	<ref group="xtra">PMID:017385760</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Guittat, L.]]		[[Category: Guittat, L.]]
	[[Category: Hounsou, C.]]		[[Category: Hounsou, C.]]
Line 36:		Line 23:
	[[Category: Quinacridine]]		[[Category: Quinacridine]]
	[[Category: Telomerase inhibitor]]		[[Category: Telomerase inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:55 2008''

OCA at 18:29, 27 July 2008

OCA — Sun, 27 Jul 2008 18:29:57 GMT

←Older revision		Revision as of 18:29, 27 July 2008
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-	[[Image:2jwq.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2jwq.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2jwq\| PDB=2jwq \| SCENE= }}		{{STRUCTURE_2jwq\| PDB=2jwq \| SCENE= }}

-	~~'''~~G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study~~'''~~	+	===G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study===


-	~~==Overview==~~	+	<!--
-	The ~~synthesis of a novel group of quinacridine-based ligands~~ (~~MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes~~: ~~FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures~~. ~~All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments~~. ~~Finally~~, ~~the activity of the MMQ series against tumor cell growth~~ is ~~reported, and~~ the ~~data support the potential of quadruplex~~-~~interactive compounds for use in anticancer approaches.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17385760}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17385760 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17385760}}

	==About this Structure==		==About this Structure==
-	2JWQ is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].	+	2JWQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].

	==Reference==		==Reference==
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	[[Category: Quinacridine]]		[[Category: Quinacridine]]
	[[Category: Telomerase inhibitor]]		[[Category: Telomerase inhibitor]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 09:~~21:40 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:55 2008''