2jx2 - Revision history

OCA at 09:42, 9 May 2024

OCA — Thu, 09 May 2024 09:42:58 GMT

←Older revision		Revision as of 09:42, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:38, 14 June 2023

OCA — Wed, 14 Jun 2023 08:38:15 GMT

←Older revision		Revision as of 08:38, 14 June 2023
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	==Solution conformation of RNA-bound NELF-E RRM==		==Solution conformation of RNA-bound NELF-E RRM==
-	<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN]] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>	+	[https://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jampani, N]]	+	[[Category: Jampani N]]
-	[[Category: Roesch, P]]	+	[[Category: Roesch P]]
-	[[Category: Schweimer, K]]	+	[[Category: Schweimer K]]
-	[[Category: Wenzel, S]]	+	[[Category: Wenzel S]]
-	[[Category: Woehrl~~, B M]]~~	+	[[Category: Woehrl BM]]
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Nelfe-rrm]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Ubl conjugation~~]]	+

OCA at 13:26, 24 November 2021

OCA — Wed, 24 Nov 2021 13:26:26 GMT

←Older revision		Revision as of 13:26, 24 November 2021
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	<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [~~http~~://pdbe.org/2jx2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [https://pdbe.org/2jx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN]] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>	+	[[https://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN]] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:51, 19 February 2020

OCA — Wed, 19 Feb 2020 06:51:30 GMT

←Older revision		Revision as of 06:51, 19 February 2020
Line 1:		Line 1:

	==Solution conformation of RNA-bound NELF-E RRM==		==Solution conformation of RNA-bound NELF-E RRM==
-	<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jx2' size='340' side='right'caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2jx2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2jx2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Negative elongation factor\|Negative elongation factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jampani, N]]		[[Category: Jampani, N]]
	[[Category: Roesch, P]]		[[Category: Roesch, P]]

OCA at 11:21, 18 July 2018

OCA — Wed, 18 Jul 2018 11:21:36 GMT

←Older revision		Revision as of 11:21, 18 July 2018
Line 1:		Line 1:
		+
	==Solution conformation of RNA-bound NELF-E RRM==		==Solution conformation of RNA-bound NELF-E RRM==
	<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://pdbe.org/2jx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://pdbe.org/2jx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 38:
	[[Category: Wenzel, S]]		[[Category: Wenzel, S]]
	[[Category: Woehrl, B M]]		[[Category: Woehrl, B M]]
		+	[[Category: Coiled coil]]
	[[Category: Nelfe-rrm]]		[[Category: Nelfe-rrm]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
Line 44:		Line 46:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
		+	[[Category: Ubl conjugation]]

OCA at 16:03, 9 February 2016

OCA — Tue, 09 Feb 2016 16:03:36 GMT

←Older revision		Revision as of 16:03, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jx2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:50, 10 September 2015

OCA — Thu, 10 Sep 2015 23:50:11 GMT

←Older revision		Revision as of 23:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://pdbe.org/2jx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jx2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jampani, N]]		[[Category: Jampani, N]]
	[[Category: Roesch, P]]		[[Category: Roesch, P]]

OCA at 07:56, 25 December 2014

OCA — Thu, 25 Dec 2014 07:56:53 GMT

←Older revision		Revision as of 07:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN]] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jampani, N.]]	+	[[Category: Jampani, N]]
-	[[Category: Roesch, P.]]	+	[[Category: Roesch, P]]
-	[[Category: Schweimer, K.]]	+	[[Category: Schweimer, K]]
-	[[Category: Wenzel, S.]]	+	[[Category: Wenzel, S]]
-	[[Category: Woehrl, B M.]]	+	[[Category: Woehrl, B M]]
	[[Category: Nelfe-rrm]]		[[Category: Nelfe-rrm]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 09:08, 30 September 2014

OCA — Tue, 30 Sep 2014 09:08:11 GMT

←Older revision		Revision as of 09:08, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jx2.~~png\|left~~\|200px]]	+	==Solution conformation of RNA-bound NELF-E RRM==
		+	<StructureSection load='2jx2' size='340' side='right' caption='[[2jx2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RDBP, NELFE, RD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The E subunit of the human heterotetrameric negative transcription elongation factor (NELF-E) contains a canonical betaalphabetabetaalphabeta RNA recognition motif (RRM) that binds to a wide variety of RNA sequences. These induce very similar conformational changes in the RRM as determined by nuclear magnetic resonance spectroscopy. Although the RNA binding interface of a canonical RRM is mainly located at its beta-sheet surface, for NELF-E RRM large chemical shift perturbations are observed for residues in the flexible C-terminal region and the loop between beta 3 and alpha 2, and both regions are distant from the interface. We determined the solution structure of single-stranded transactivator responsive element (TAR) RNA-bound NELF-E RRM. This structure clearly shows that RNA binding to NELF-E RRM induces formation of a helix in the C-terminus. The RNA-bound form of NELF-E RRM is very similar to the RNA-bound form of U1A RRM, although the C-terminus of the NELF-E RRM is unstructured in the free protein, whereas it is helical in the U1A protein. Thus, RNA binding to NELF-E RRM induces a conformational change toward the U1A structure, resulting in highly similar RNA binding conformations for both proteins.

-	~~{{STRUCTURE_2jx2\| PDB=2jx2 \| SCENE= }}~~	+	NELF-E RRM Undergoes Major Structural Changes in Flexible Protein Regions on Target RNA Binding.,Rao JN, Schweimer K, Wenzel S, Wohrl BM, Rosch P Biochemistry. 2008 Mar 25;47(12):3756-61. Epub 2008 Feb 28. PMID:18303858<ref>PMID:18303858</ref>

-	~~===Solution conformation~~ of ~~RNA-bound NELF-E RRM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18303858}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jx2]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JX2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018303858<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jampani, N.]]		[[Category: Jampani, N.]]

OCA: Protected "2jx2" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:25:03 GMT

Protected "2jx2" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:25, 7 January 2013