2jx6 - Revision history

OCA at 12:49, 20 December 2023

OCA — Wed, 20 Dec 2023 12:49:04 GMT

←Older revision		Revision as of 12:49, 20 December 2023
Line 1:		Line 1:

	==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==		==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==
-	<StructureSection load='2jx6' size='340' side='right'caption='[[2jx6~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jx6' size='340' side='right'caption='[[2jx6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phyllomedusa_distincta Phyllomedusa distincta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [https://pdbe.org/2jx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [https://pdbe.org/2jx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~DDSK_PHYDS DDSK_PHYDS]~~] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>	+	[https://www.uniprot.org/uniprot/DRS1_PHYDS DRS1_PHYDS] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almeida~~, F C.L~~]]	+	[[Category: Phyllomedusa distincta]]
-	[[Category: Bechinger, B]]	+	[[Category: Almeida FCL]]
-	[[Category: Bemquerer~~, M P~~]]	+	[[Category: Bechinger B]]
-	[[Category: Moraes, C ~~Mendonca~~]]	+	[[Category: Bemquerer MP]]
-	[[Category: Pilo-Veloso, D]]	+	[[Category: Mendonca Moraes C]]
-	[[Category: Resende~~, J M~~]]	+	[[Category: Pilo-Veloso D]]
-	[[Category: Valente, A]]	+	[[Category: Resende JM]]
-	[[Category: Verly~~, R M]]~~	+	[[Category: Valente A]]
-	~~[[Category: Alpha helix]]~~	+	[[Category: Verly RM]]
-	~~[[Category: Amphibian defense peptide]]~~	+
-	~~[[Category: Amphipathic character]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: C-terminal carboxyamidation]]~~	+
-	~~[[Category: Membrane peptide]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 07:29, 27 January 2022

OCA — Thu, 27 Jan 2022 07:29:51 GMT

←Older revision		Revision as of 07:29, 27 January 2022
Line 3:		Line 3:
	<StructureSection load='2jx6' size='340' side='right'caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jx6' size='340' side='right'caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [~~http~~://pdbe.org/2jx6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [https://pdbe.org/2jx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DDSK_PHYDS DDSK_PHYDS]] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>	+	[[https://www.uniprot.org/uniprot/DDSK_PHYDS DDSK_PHYDS]] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:29, 22 April 2020

OCA — Wed, 22 Apr 2020 06:29:23 GMT

←Older revision		Revision as of 06:29, 22 April 2020
Line 1:		Line 1:

	==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==		==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==
-	<StructureSection load='2jx6' size='340' side='right' caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jx6' size='340' side='right'caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://pdbe.org/2jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://pdbe.org/2jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Almeida, F C.L]]		[[Category: Almeida, F C.L]]
	[[Category: Bechinger, B]]		[[Category: Bechinger, B]]

OCA at 10:35, 18 July 2018

OCA — Wed, 18 Jul 2018 10:35:53 GMT

←Older revision		Revision as of 10:35, 18 July 2018
Line 1:		Line 1:
		+
	==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==		==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==
	<StructureSection load='2jx6' size='340' side='right' caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jx6' size='340' side='right' caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://pdbe.org/2jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://pdbe.org/2jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:14, 11 September 2015

OCA — Fri, 11 Sep 2015 00:14:51 GMT

←Older revision		Revision as of 00:14, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://pdbe.org/2jx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jx6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:12, 25 December 2014

OCA — Thu, 25 Dec 2014 08:12:05 GMT

←Older revision		Revision as of 08:12, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DDSK_PHYDS DDSK_PHYDS]] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Almeida, F C.L.]]	+	[[Category: Almeida, F C.L]]
-	[[Category: Bechinger, B.]]	+	[[Category: Bechinger, B]]
-	[[Category: Bemquerer, M P.]]	+	[[Category: Bemquerer, M P]]
-	[[Category: Moraes, C Mendonca.]]	+	[[Category: Moraes, C Mendonca]]
-	[[Category: Pilo-Veloso, D.]]	+	[[Category: Pilo-Veloso, D]]
-	[[Category: Resende, J M.]]	+	[[Category: Resende, J M]]
-	[[Category: Valente, A.]]	+	[[Category: Valente, A]]
-	[[Category: Verly, R M.]]	+	[[Category: Verly, R M]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Amphibian defense peptide]]		[[Category: Amphibian defense peptide]]

OCA at 15:37, 12 October 2014

OCA — Sun, 12 Oct 2014 15:37:49 GMT

←Older revision		Revision as of 15:37, 12 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2jx6.~~png~~\|~~left\|200px~~]]	+	==Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy==
		+	<StructureSection load='2jx6' size='340' side='right' caption='[[2jx6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JX6 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jx6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DD K, a peptide first isolated from the skin secretion of the Phyllomedusa distincta frog, has been prepared by solid-phase chemical peptide synthesis and its conformation was studied in trifluoroethanol/water as well as in the presence of sodium dodecyl sulfate and dodecylphosphocholine micelles or small unilamellar vesicles. Multidimensional solution NMR spectroscopy indicates an alpha-helical conformation in membrane environments starting at residue 7 and extending to the C-terminal carboxyamide. Furthermore, DD K has been labeled with (15)N at a single alanine position that is located within the helical core region of the sequence. When reconstituted into oriented phosphatidylcholine membranes the resulting (15)N solid-state NMR spectrum shows a well-defined helix alignment parallel to the membrane surface in excellent agreement with the amphipathic character of DD K. Proton-decoupled (31)P solid-state NMR spectroscopy indicates that the peptide creates a high level of disorder at the level of the phospholipid headgroup suggesting that DD K partitions into the bilayer where it severely disrupts membrane packing.

-	~~{{STRUCTURE_2jx6\| PDB=2jx6 \| SCENE= }}~~	+	Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy.,Verly RM, de Moraes CM, Resende JM, Aisenbrey C, Bemquerer MP, Pilo-Veloso D, Valente AP, Almeida FC, Bechinger B Biophys J. 2009 Mar 18;96(6):2194-203. PMID:19289046<ref>PMID:19289046</ref>

-	~~===Structure and membrane interactions~~ of the ~~antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19289046}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jx6]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2JX6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019289046<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Almeida, F C.L.]]		[[Category: Almeida, F C.L.]]
	[[Category: Bechinger, B.]]		[[Category: Bechinger, B.]]

OCA: Protected "2jx6" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:43:18 GMT

Protected "2jx6" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:43, 7 January 2013

OCA at 11:43, 7 January 2013

OCA — Mon, 07 Jan 2013 11:43:15 GMT

←Older revision		Revision as of 11:43, 7 January 2013
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-	{{Seed}}
	[[Image:2jx6.png\|left\|200px]]		[[Image:2jx6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jx6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jx6\| PDB=2jx6 \| SCENE= }}		{{STRUCTURE_2jx6\| PDB=2jx6 \| SCENE= }}

	===Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy===		===Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19289046}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19289046 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19289046}}		{{ABSTRACT_PUBMED_19289046}}

	==About this Structure==		==About this Structure==
-	~~2JX6~~ is a 1 chain structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA].	+	[[2jx6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19289046~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019289046</ref><references group="xtra"/>
	[[Category: Almeida, F C.L.]]		[[Category: Almeida, F C.L.]]
	[[Category: Bechinger, B.]]		[[Category: Bechinger, B.]]
Line 40:		Line 28:
	[[Category: C-terminal carboxyamidation]]		[[Category: C-terminal carboxyamidation]]
	[[Category: Membrane peptide]]		[[Category: Membrane peptide]]
-	[[Category: Peptide]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:27:21 2009''

OCA at 12:27, 2 April 2009

OCA — Thu, 02 Apr 2009 12:27:22 GMT

←Older revision		Revision as of 12:27, 2 April 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2jx6.~~jpg~~\|left\|200px]]	+	[[Image:2jx6.png\|left\|200px]]

	<!--		<!--
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	===Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy===		===Structure and membrane interactions of the antibiotic peptide dermadistinctin k by solution and oriented 15N and 31P solid-state NMR spectroscopy===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19289046}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19289046 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19289046}}

	==About this Structure==		==About this Structure==
-	2JX6 is a 1 chain structure. Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA].	+	2JX6 is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19289046</ref><references group="xtra"/>
		+	[[Category: Almeida, F C.L.]]
		+	[[Category: Bechinger, B.]]
		+	[[Category: Bemquerer, M P.]]
		+	[[Category: Moraes, C Mendonca.]]
		+	[[Category: Pilo-Veloso, D.]]
		+	[[Category: Resende, J M.]]
		+	[[Category: Valente, A.]]
		+	[[Category: Verly, R M.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Amphibian defense peptide]]		[[Category: Amphibian defense peptide]]
Line 26:		Line 43:
	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 12 10~~:41:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:27:21 2009''