2jxb - Revision history

OCA at 19:06, 29 May 2024

OCA — Wed, 29 May 2024 19:06:53 GMT

←Older revision		Revision as of 19:06, 29 May 2024
Line 1:		Line 1:

	==Structure of CD3epsilon-Nck2 first SH3 domain complex==		==Structure of CD3epsilon-Nck2 first SH3 domain complex==
-	<StructureSection load='2jxb' size='340' side='right'caption='[[2jxb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jxb' size='340' side='right'caption='[[2jxb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CD3E, NCK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 Homo sapiens])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [https://pdbe.org/2jxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [https://www.ebi.ac.uk/pdbsum/2jxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [https://pdbe.org/2jxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [https://www.ebi.ac.uk/pdbsum/2jxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>	+	[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ng, E]]	+	[[Category: Ng E]]
-	[[Category: Park, S]]	+	[[Category: Park S]]
-	[[Category: Reinherz~~, E L~~]]	+	[[Category: Reinherz EL]]
-	[[Category: Sun~~, Z J~~]]	+	[[Category: Sun ZJ]]
-	[[Category: Takeuchi, K]]	+	[[Category: Takeuchi K]]
-	[[Category: Wagner, G]]	+	[[Category: Wagner G]]
-	[[Category: Yang, H]]	+	[[Category: Yang H]]
-	~~[[Category: Cd3epsilon]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Immunology]]~~	+
-	~~[[Category: Nck]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Signaling protein complex]]~~	+
-	~~[[Category: T-cell receptor~~]]	+

OCA at 08:00, 7 April 2021

OCA — Wed, 07 Apr 2021 08:00:57 GMT

←Older revision		Revision as of 08:00, 7 April 2021
Line 1:		Line 1:

	==Structure of CD3epsilon-Nck2 first SH3 domain complex==		==Structure of CD3epsilon-Nck2 first SH3 domain complex==
-	<StructureSection load='2jxb' size='340' side='right' caption='[[2jxb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jxb' size='340' side='right'caption='[[2jxb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [~~http~~://pdbe.org/2jxb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jxb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [https://pdbe.org/2jxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [https://www.ebi.ac.uk/pdbsum/2jxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>	+	[[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[CD3\|CD3]]	+	*[[CD3 3D structures\|CD3 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Ng, E]]		[[Category: Ng, E]]
	[[Category: Park, S]]		[[Category: Park, S]]

OCA at 10:33, 18 July 2018

OCA — Wed, 18 Jul 2018 10:33:22 GMT

←Older revision		Revision as of 10:33, 18 July 2018
Line 1:		Line 1:
		+
	==Structure of CD3epsilon-Nck2 first SH3 domain complex==		==Structure of CD3epsilon-Nck2 first SH3 domain complex==
	<StructureSection load='2jxb' size='340' side='right' caption='[[2jxb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jxb' size='340' side='right' caption='[[2jxb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://pdbe.org/2jxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://pdbe.org/2jxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 43:		Line 44:
	[[Category: Yang, H]]		[[Category: Yang, H]]
	[[Category: Cd3epsilon]]		[[Category: Cd3epsilon]]
		+	[[Category: Cytoplasm]]
	[[Category: Immunology]]		[[Category: Immunology]]
	[[Category: Nck]]		[[Category: Nck]]

OCA at 01:30, 12 September 2015

OCA — Sat, 12 Sep 2015 01:30:27 GMT

←Older revision		Revision as of 01:30, 12 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://pdbe.org/2jxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jxb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:01, 25 December 2014

OCA — Thu, 25 Dec 2014 22:01:14 GMT

←Older revision		Revision as of 22:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ng, E.]]	+	[[Category: Ng, E]]
-	[[Category: Park, S.]]	+	[[Category: Park, S]]
-	[[Category: Reinherz, E L.]]	+	[[Category: Reinherz, E L]]
-	[[Category: Sun, Z J.]]	+	[[Category: Sun, Z J]]
-	[[Category: Takeuchi, K.]]	+	[[Category: Takeuchi, K]]
-	[[Category: Wagner, G.]]	+	[[Category: Wagner, G]]
-	[[Category: Yang, H.]]	+	[[Category: Yang, H]]
	[[Category: Cd3epsilon]]		[[Category: Cd3epsilon]]
	[[Category: Immunology]]		[[Category: Immunology]]

OCA at 09:26, 30 September 2014

OCA — Tue, 30 Sep 2014 09:26:12 GMT

←Older revision		Revision as of 09:26, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jxb.~~png\|left~~\|200px]]	+	==Structure of CD3epsilon-Nck2 first SH3 domain complex==
		+	<StructureSection load='2jxb' size='340' side='right' caption='[[2jxb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recruitment of signaling molecules to the cytoplasmic domains of the CD3 subunits of the T-cell receptor (TCR) is crucial for early T-cell activation. These transient associations either do or do not require tyrosine phosphorylation of CD3 immune tyrosine activation motifs (ITAMs). Here we show that the non-ITAM-requiring adaptor protein Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the ITAM and a TCR endocytosis signal. As suggested by the structure of the complex, we find that Nck binding inhibits phosphorylation of the CD3epsilon ITAM by Fyn and Lck kinases in vitro. Moreover, the CD3epsilon-Nck interaction downregulates TCR surface expression upon physiological stimulation in mouse primary lymph node cells. This indicates that Nck performs an important regulatory function in T lymphocytes by inhibiting ITAM phosphorylation and/or removing cell surface TCR via CD3epsilon interaction.

-	~~{{STRUCTURE_2jxb\| PDB=2jxb \| SCENE= }}~~	+	Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.,Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G J Mol Biol. 2008 Jul 18;380(4):704-16. Epub 2008 May 22. PMID:18555270<ref>PMID:18555270</ref>

-	~~===Structure~~ of ~~CD3epsilon-Nck2 first SH3 domain complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18555270}}~~	+	==See Also==
-		+	*[[CD3\|CD3]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2jxb~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018555270<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ng, E.]]		[[Category: Ng, E.]]

OCA: Protected "2jxb" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:19:56 GMT

Protected "2jxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:19, 7 January 2013

OCA at 14:19, 7 January 2013

OCA — Mon, 07 Jan 2013 14:19:52 GMT

←Older revision		Revision as of 14:19, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jxb.png\|left\|200px]]		[[Image:2jxb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jxb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jxb\| PDB=2jxb \| SCENE= }}		{{STRUCTURE_2jxb\| PDB=2jxb \| SCENE= }}

	===Structure of CD3epsilon-Nck2 first SH3 domain complex===		===Structure of CD3epsilon-Nck2 first SH3 domain complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18555270}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18555270 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18555270}}		{{ABSTRACT_PUBMED_18555270}}

	==About this Structure==		==About this Structure==
-	~~2JXB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].	+	[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18555270~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018555270</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ng, E.]]		[[Category: Ng, E.]]
Line 33:		Line 21:
	[[Category: Yang, H.]]		[[Category: Yang, H.]]
	[[Category: Cd3epsilon]]		[[Category: Cd3epsilon]]
-	[[Category: Cytoplasm]]
	[[Category: Immunology]]		[[Category: Immunology]]
	[[Category: Nck]]		[[Category: Nck]]
Line 40:		Line 27:
	[[Category: Signaling protein complex]]		[[Category: Signaling protein complex]]
	[[Category: T-cell receptor]]		[[Category: T-cell receptor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:12:41 2009''

OCA at 07:12, 18 February 2009

OCA — Wed, 18 Feb 2009 07:12:42 GMT

←Older revision		Revision as of 07:12, 18 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2jxb.~~jpg~~\|left\|200px]]	+	[[Image:2jxb.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JXB is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].	+	2JXB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].

	==Reference==		==Reference==
-	Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity., Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G, J Mol Biol. 2008 Jul 18;380(4):704-16. Epub 2008 May 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18555270 18555270]~~	+	<ref group="xtra">PMID:18555270</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Ng, E.]]		[[Category: Ng, E.]]
	[[Category: Park, S.]]		[[Category: Park, S.]]
Line 42:		Line 41:
	[[Category: T-cell receptor]]		[[Category: T-cell receptor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 24 10~~:30:~~16 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:12:41 2009''

OCA at 07:30, 24 September 2008

OCA — Wed, 24 Sep 2008 07:30:19 GMT

←Older revision		Revision as of 07:30, 24 September 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2jxb.jpg\|left\|200px]]

-	The ~~entry 2jxb~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2jxb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2jxb\| PDB=2jxb \| SCENE= }}

-	~~Authors: Takeuchi, K., Yang, H., Ng, E., Park, S., Sun, Z.J., Reinherz, E.L., Wagner, G.~~	+	===Structure of CD3epsilon-Nck2 first SH3 domain complex===

-	~~Description~~: Structure of CD3epsilon-~~Nck2 first SH3~~ domain complex	+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 08~~:32:44 2008''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18555270}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18555270 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18555270}}
		+
		+	==About this Structure==
		+	2JXB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA].
		+
		+	==Reference==
		+	Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity., Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G, J Mol Biol. 2008 Jul 18;380(4):704-16. Epub 2008 May 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18555270 18555270]
		+	[[Category: Homo sapiens]]
		+	[[Category: Single protein]]
		+	[[Category: Ng, E.]]
		+	[[Category: Park, S.]]
		+	[[Category: Reinherz, E L.]]
		+	[[Category: Sun, Z J.]]
		+	[[Category: Takeuchi, K.]]
		+	[[Category: Wagner, G.]]
		+	[[Category: Yang, H.]]
		+	[[Category: Cd3epsilon]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Immunology]]
		+	[[Category: Nck]]
		+	[[Category: Sh2 domain]]
		+	[[Category: Sh3 domain]]
		+	[[Category: Signaling protein complex]]
		+	[[Category: T-cell receptor]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:30:16 2008''