2jxv - Revision history

OCA at 12:49, 20 December 2023

OCA — Wed, 20 Dec 2023 12:49:09 GMT

←Older revision		Revision as of 12:49, 20 December 2023
Line 1:		Line 1:

	==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==		==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==
-	<StructureSection load='2jxv' size='340' side='right'caption='[[2jxv~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2jxv' size='340' side='right'caption='[[2jxv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [https://pdbe.org/2jxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [https://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [https://pdbe.org/2jxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [https://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cevec, M]]	+	[[Category: Cevec M]]
-	[[Category: Plavec, J]]	+	[[Category: Plavec J]]
-	[[Category: Thibaudeau, C]]	+	[[Category: Thibaudeau C]]
-	~~[[Category: Asymmetric internal loop]]~~	+
-	~~[[Category: Gaaa tetraloop]]~~	+
-	~~[[Category: Gu mismatch]]~~	+
-	~~[[Category: Residual dipolar coupling]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Stem-loop~~]]	+

OCA at 07:30, 27 January 2022

OCA — Thu, 27 Jan 2022 07:30:06 GMT

←Older revision		Revision as of 07:30, 27 January 2022
Line 3:		Line 3:
	<StructureSection load='2jxv' size='340' side='right'caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jxv' size='340' side='right'caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [~~http~~://pdbe.org/2jxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [https://pdbe.org/2jxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [https://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:29, 22 April 2020

OCA — Wed, 22 Apr 2020 06:29:43 GMT

←Older revision		Revision as of 06:29, 22 April 2020
Line 1:		Line 1:

	==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==		==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==
-	<StructureSection load='2jxv' size='340' side='right' caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2jxv' size='340' side='right'caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://pdbe.org/2jxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://pdbe.org/2jxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cevec, M]]		[[Category: Cevec, M]]
	[[Category: Plavec, J]]		[[Category: Plavec, J]]

OCA at 10:58, 18 July 2018

OCA — Wed, 18 Jul 2018 10:58:01 GMT

←Older revision		Revision as of 10:58, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==		==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==
	<StructureSection load='2jxv' size='340' side='right' caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jxv' size='340' side='right' caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://pdbe.org/2jxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://pdbe.org/2jxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:40, 11 September 2015

OCA — Fri, 11 Sep 2015 05:40:12 GMT

←Older revision		Revision as of 05:40, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://pdbe.org/2jxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jxv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:34, 22 December 2014

OCA — Mon, 22 Dec 2014 06:34:11 GMT

←Older revision		Revision as of 06:34, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cevec, M.]]	+	[[Category: Cevec, M]]
-	[[Category: Plavec, J.]]	+	[[Category: Plavec, J]]
-	[[Category: Thibaudeau, C.]]	+	[[Category: Thibaudeau, C]]
	[[Category: Asymmetric internal loop]]		[[Category: Asymmetric internal loop]]
	[[Category: Gaaa tetraloop]]		[[Category: Gaaa tetraloop]]

OCA at 07:04, 9 June 2014

OCA — Mon, 09 Jun 2014 07:04:34 GMT

←Older revision		Revision as of 07:04, 9 June 2014
Line 1:		Line 1:
-	[[~~Image~~:2jxv.~~png\|left\|200px~~]]	+	==Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans==
		+	<StructureSection load='2jxv' size='340' side='right' caption='[[2jxv]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxv RCSB], [http://www.ebi.ac.uk/pdbsum/2jxv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Let-7 microRNA (miRNA) regulates heterochronic genes in developmental timing of the nematode Caenorhabditis elegans. Binding of miRNA to messenger RNA (mRNA) and structural features of the complex are crucial for gene silencing. We herein present the NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site (LCS 2) in the 3' untranslated region (3'-UTR) of the lin-41 mRNA. A structural study was performed by NMR spectroscopy using NOE restraints, torsion angle restraints and residual dipolar couplings. The 33-nt RNA construct folds into a stem-loop structure that features two stem regions which are separated by an asymmetric internal loop. One of the stems comprises a GU wobble base pair, which does not alter its overall A-form RNA conformation. The asymmetric internal loop adopts a single, well-defined structure in which three uracils form a base triple, while two adenines form a base pair. The 3D structure of the construct gives insight into the structural aspects of interactions between let-7 miRNA and lin-41 mRNA.

-	~~{{STRUCTURE_2jxv\| PDB=2jxv \| SCENE= }}~~	+	Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans.,Cevec M, Thibaudeau C, Plavec J Nucleic Acids Res. 2008 Apr;36(7):2330-7. Epub 2008 Feb 22. PMID:18296482<ref>PMID:18296482</ref>

-	~~===Solution structure~~ of ~~a let-7 miRNA:lin-41 mRNA complex from C~~. ~~elegans===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18296482}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jxv]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann.ac.il~~/~~oca-bin/ocashort?id=2JXV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018296482<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cevec, M.]]		[[Category: Cevec, M.]]
	[[Category: Plavec, J.]]		[[Category: Plavec, J.]]

OCA: Protected "2jxv" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:47:21 GMT

Protected "2jxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:47, 14 August 2012

OCA at 18:47, 14 August 2012

OCA — Tue, 14 Aug 2012 18:47:19 GMT

←Older revision		Revision as of 18:47, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jxv.png\|left\|200px]]		[[Image:2jxv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jxv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jxv\| PDB=2jxv \| SCENE= }}		{{STRUCTURE_2jxv\| PDB=2jxv \| SCENE= }}

	===Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans===		===Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18296482}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18296482 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18296482}}		{{ABSTRACT_PUBMED_18296482}}

	==About this Structure==		==About this Structure==
-	~~2JXV is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].	+	[[2jxv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].

	==Reference==		==Reference==
-	~~Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans., Cevec M, Thibaudeau C, Plavec J, Nucleic Acids Res. 2008 Apr;36(7):2330-7. Epub 2008 Feb 22.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18296482 18296482]~~	+	<ref group="xtra">PMID:018296482</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Cevec, M.]]		[[Category: Cevec, M.]]
	[[Category: Plavec, J.]]		[[Category: Plavec, J.]]
Line 32:		Line 19:
	[[Category: Gu mismatch]]		[[Category: Gu mismatch]]
	[[Category: Residual dipolar coupling]]		[[Category: Residual dipolar coupling]]
		+	[[Category: Rna]]
	[[Category: Stem-loop]]		[[Category: Stem-loop]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:23:37 2008''

OCA at 18:23, 28 July 2008

OCA — Mon, 28 Jul 2008 18:23:41 GMT

←Older revision		Revision as of 18:23, 28 July 2008
Line 1:		Line 1:
-	[[Image:2jxv.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2jxv.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2jxv\| PDB=2jxv \| SCENE= }}		{{STRUCTURE_2jxv\| PDB=2jxv \| SCENE= }}

-	~~'''~~Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans~~'''~~	+	===Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans===


-	~~==Overview==~~	+	<!--
-	~~Let-7 microRNA (miRNA) regulates heterochronic genes in developmental timing of~~ the ~~nematode Caenorhabditis elegans. Binding of miRNA~~ to ~~messenger RNA~~ (~~mRNA) and structural features of the complex are crucial for gene silencing~~. ~~We herein present the NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site (LCS 2~~) ~~in the 3' untranslated region (3'-UTR) of the lin-41 mRNA. A structural study was performed by NMR spectroscopy using NOE restraints~~, torsion angle restraints and residual dipolar couplings. The 33-nt RNA construct folds into a stem-loop structure that features two stem regions which are separated by an asymmetric internal loop. One of the ~~stems comprises a GU wobble base pair, which does not alter its overall A-form RNA conformation~~. ~~The asymmetric internal loop adopts a single, well~~-defined structure in which three uracils form a base triple, while two adenines form a base pair. The 3D structure of the construct gives insight into the structural aspects of interactions between let-~~7 miRNA and lin-41 mRNA.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18296482}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18296482 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18296482}}

	==About this Structure==		==About this Structure==
-	2JXV is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].	+	2JXV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].

	==Reference==		==Reference==
Line 29:		Line 33:
	[[Category: Residual dipolar coupling]]		[[Category: Residual dipolar coupling]]
	[[Category: Stem-loop]]		[[Category: Stem-loop]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 30 12~~:49:58 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:23:37 2008''