2jyq - Revision history

OCA at 19:07, 29 May 2024

OCA — Wed, 29 May 2024 19:07:27 GMT

←Older revision		Revision as of 19:07, 29 May 2024
Line 1:		Line 1:

	==NMR structure of the apo v-Src SH2 domain==		==NMR structure of the apo v-Src SH2 domain==
-	<StructureSection load='2jyq' size='340' side='right'caption='[[2jyq~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jyq' size='340' side='right'caption='[[2jyq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>V-SRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=11886 Rous sarcoma virus])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [https://pdbe.org/2jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [https://www.ebi.ac.uk/pdbsum/2jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [https://pdbe.org/2jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [https://www.ebi.ac.uk/pdbsum/2jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SRC_RSVSE SRC_RSVSE]] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro (By similarity).	+	[https://www.uniprot.org/uniprot/SRC_RSVSE SRC_RSVSE] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]
-	[[Category: Ababou, A]]	+	[[Category: Ababou A]]
-	[[Category: Ladbury~~, J E~~]]	+	[[Category: Ladbury JE]]
-	[[Category: Taylor~~, J D~~]]	+	[[Category: Taylor JD]]
-	[[Category: Williams~~, M A]]~~	+	[[Category: Williams MA]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Myristate]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Oncogene]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Sh2]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Src]]~~	+
-	~~[[Category: Src homology 2]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tyrosine-protein kinase~~]]	+

OCA at 08:02, 7 April 2021

OCA — Wed, 07 Apr 2021 08:02:35 GMT

←Older revision		Revision as of 08:02, 7 April 2021
Line 1:		Line 1:

	==NMR structure of the apo v-Src SH2 domain==		==NMR structure of the apo v-Src SH2 domain==
-	<StructureSection load='2jyq' size='340' side='right' caption='[[2jyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jyq' size='340' side='right'caption='[[2jyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [~~http~~://pdbe.org/2jyq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jyq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [https://pdbe.org/2jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [https://www.ebi.ac.uk/pdbsum/2jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SRC_RSVSE SRC_RSVSE]] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro (By similarity).	+	[[https://www.uniprot.org/uniprot/SRC_RSVSE SRC_RSVSE]] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Tyrosine kinase\|Tyrosine kinase]]	+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]

OCA at 11:23, 18 July 2018

OCA — Wed, 18 Jul 2018 11:23:45 GMT

←Older revision		Revision as of 11:23, 18 July 2018
Line 1:		Line 1:
		+
	==NMR structure of the apo v-Src SH2 domain==		==NMR structure of the apo v-Src SH2 domain==
	<StructureSection load='2jyq' size='340' side='right' caption='[[2jyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jyq' size='340' side='right' caption='[[2jyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://pdbe.org/2jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://pdbe.org/2jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jyq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:11, 12 September 2015

OCA — Sat, 12 Sep 2015 01:11:33 GMT

←Older revision		Revision as of 01:11, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://pdbe.org/2jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jyq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine kinase\|Tyrosine kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:50, 25 December 2014

OCA — Thu, 25 Dec 2014 21:50:36 GMT

←Older revision		Revision as of 21:50, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SRC_RSVSE SRC_RSVSE]] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]
-	[[Category: Ababou, A.]]	+	[[Category: Ababou, A]]
-	[[Category: Ladbury, J E.]]	+	[[Category: Ladbury, J E]]
-	[[Category: Taylor, J D.]]	+	[[Category: Taylor, J D]]
-	[[Category: Williams, M A.]]	+	[[Category: Williams, M A]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 09:09, 30 September 2014

OCA — Tue, 30 Sep 2014 09:09:35 GMT

←Older revision		Revision as of 09:09, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jyq.~~png\|left~~\|200px]]	+	==NMR structure of the apo v-Src SH2 domain==
		+	<StructureSection load='2jyq' size='340' side='right' caption='[[2jyq]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyq RCSB], [http://www.ebi.ac.uk/pdbsum/2jyq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SH2 domains provide fundamental recognition sites in tyrosine kinase-mediated signaling pathways which, when aberrant, give rise to disease states such as cancer, diabetes, and immune deficiency. Designing specific inhibitors that target the SH2 domain-binding site, however, have presented a major challenge. Despite well over a decade of intensive research, clinically useful SH2 domain inhibitors have yet to become available. A better understanding of the structural, dynamic, and thermodynamic contributions to ligand binding of individual SH2 domains will provide some insight as to whether inhibitor development is possible. We report the first high resolution solution structure of the apo-v-Src SH2 domain. This is accompanied by the analysis of backbone dynamics and pK(a) values within the apo- and peptide-bound states. Our results indicate that the phosphotyrosine (pY) pocket is tightly structured and hence not adaptable to exogenous ligands. On the other hand, the pocket which accommodates residues proximal and C-terminal of the pY (pY + 3) or so-called specificity determining region, is a large dynamic-binding surface. This appears to allow a high level of promiscuity in binding. Binding of a series of synthetic, phosphotyrosyl, peptidomimetic compounds designed to explore interactions in the pY + 3 pocket further demonstrates the ability of the SH2 domain to accommodate diverse ligands. The thermodynamic parameters of these interactions show dramatic enthalpy/entropy compensation. These data suggest that the v-Src SH2 domain does not have a highly specific secondary-binding site, which clearly presents a major hurdle to design selective inhibitors. Proteins 2008. (c) 2008 Wiley-Liss, Inc.

-	~~{{STRUCTURE_2jyq\| PDB=2jyq \| SCENE= }}~~	+	Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design.,Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE Proteins. 2008 Jun 5;. PMID:18536014<ref>PMID:18536014</ref>

-	~~===NMR structure~~ of the ~~apo v-Src SH2 domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18536014}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jyq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rous_sarcoma_virus Rous sarcoma virus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018536014<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]

OCA: Protected "2jyq" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:05:14 GMT

Protected "2jyq" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:05, 7 January 2013

OCA at 14:05, 7 January 2013

OCA — Mon, 07 Jan 2013 14:05:13 GMT

←Older revision		Revision as of 14:05, 7 January 2013
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-	{{Seed}}
	[[Image:2jyq.png\|left\|200px]]		[[Image:2jyq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jyq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jyq\| PDB=2jyq \| SCENE= }}		{{STRUCTURE_2jyq\| PDB=2jyq \| SCENE= }}

	===NMR structure of the apo v-Src SH2 domain===		===NMR structure of the apo v-Src SH2 domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18536014}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18536014 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18536014}}		{{ABSTRACT_PUBMED_18536014}}

	==About this Structure==		==About this Structure==
-	~~2JYQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA].	+	[[2jyq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18536014~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018536014</ref><references group="xtra"/>
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]
Line 45:		Line 33:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:56:57 2009''

OCA at 06:56, 18 February 2009

OCA — Wed, 18 Feb 2009 06:56:58 GMT

←Older revision		Revision as of 06:56, 18 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	~~Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design., Taylor JD, Ababou A, Fawaz RR, Hobbs CJ, Williams MA, Ladbury JE, Proteins. 2008 Jun 5;.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18536014 18536014]~~	+	<ref group="xtra">PMID:18536014</ref><references group="xtra"/>
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]
Line 46:		Line 46:
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Nov 27 13~~:48:~~39 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:56:57 2009''

OCA at 11:48, 27 November 2008

OCA — Thu, 27 Nov 2008 11:48:42 GMT

←Older revision		Revision as of 11:48, 27 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2JYQ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA].	+	2JYQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYQ OCA].

	==Reference==		==Reference==
Line 26:		Line 26:
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rous sarcoma virus]]		[[Category: Rous sarcoma virus]]
-	[[Category: Single protein]]
	[[Category: Ababou, A.]]		[[Category: Ababou, A.]]
	[[Category: Ladbury, J E.]]		[[Category: Ladbury, J E.]]
Line 47:		Line 46:
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov ~~26 20~~:39:40 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:48:39 2008''