2jyt - Revision history

OCA at 08:02, 7 April 2021

OCA — Wed, 07 Apr 2021 08:02:39 GMT

←Older revision		Revision as of 08:02, 7 April 2021
Line 1:		Line 1:

	==Human Granulin C, isomer 1==		==Human Granulin C, isomer 1==
-	<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2jyt' size='340' side='right'caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYT FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [~~http~~://pdbe.org/2jyt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jyt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [https://pdbe.org/2jyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [https://www.ebi.ac.uk/pdbsum/2jyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[~~http~~://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref> <ref>PMID:16983685</ref> <ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[~~http~~://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>	+	[[https://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[https://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref> <ref>PMID:16983685</ref> <ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[https://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.	+	[[https://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Ni, F]]		[[Category: Ni, F]]

OCA at 10:50, 18 July 2018

OCA — Wed, 18 Jul 2018 10:50:01 GMT

←Older revision		Revision as of 10:50, 18 July 2018
Line 1:		Line 1:
		+
	==Human Granulin C, isomer 1==		==Human Granulin C, isomer 1==
	<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://pdbe.org/2jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://pdbe.org/2jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jyt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 40:		Line 41:
	[[Category: Wang, P]]		[[Category: Wang, P]]
	[[Category: Xu, P]]		[[Category: Xu, P]]
		+	[[Category: Alternative splicing]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Epithelin]]		[[Category: Epithelin]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Granulin c]]		[[Category: Granulin c]]
		+	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Stack of hairpin]]		[[Category: Stack of hairpin]]

OCA at 11:28, 11 September 2015

OCA — Fri, 11 Sep 2015 11:28:37 GMT

←Older revision		Revision as of 11:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://pdbe.org/2jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jyt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Ni, F]]		[[Category: Ni, F]]
Line 43:		Line 44:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Granulin c]]		[[Category: Granulin c]]
-	[[Category: Human]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Stack of hairpin]]		[[Category: Stack of hairpin]]

OCA at 15:38, 19 January 2015

OCA — Mon, 19 Jan 2015 15:38:27 GMT

←Older revision		Revision as of 15:38, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[http://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref> <ref>PMID:16983685</ref> <ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[http://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>		[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[http://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref> <ref>PMID:16983685</ref> <ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[http://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Ni, F.]]	+	[[Category: Ni, F]]
-	[[Category: Tolkatchev, D.]]	+	[[Category: Tolkatchev, D]]
-	[[Category: Wang, P.]]	+	[[Category: Wang, P]]
-	[[Category: Xu, P.]]	+	[[Category: Xu, P]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Epithelin]]		[[Category: Epithelin]]

OCA at 08:48, 30 September 2014

OCA — Tue, 30 Sep 2014 08:48:50 GMT

←Older revision		Revision as of 08:48, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2jyt\| PDB~~=2jyt \| ~~SCENE~~= }}	+	==Human Granulin C, isomer 1==
-	===~~Human Granulin C, isomer~~ 1===	+	<StructureSection load='2jyt' size='340' side='right' caption='[[2jyt]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_18359860}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYT FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qgm\|1qgm]], [[1g26\|1g26]], [[1fwo\|1fwo]], [[2jye\|2jye]], [[2jyu\|2jyu]], [[2jyv\|2jyv]]</td></tr>
-	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[http://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref><ref>PMID:16983685</ref><ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[http://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jyt RCSB], [http://www.ebi.ac.uk/pdbsum/2jyt PDBsum]</span></td></tr>
-	==Function==	+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[http://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref> <ref>PMID:16983685</ref> <ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[http://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.		[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Progranulin is a secreted protein with important functions in several physiological and pathological processes, such as embryonic development, host defense, and wound repair. Autosomal dominant mutations in the progranulin gene cause frontotemporal dementia, while overexpression of progranulin promotes the invasive progression of a range of tumors, including those of the breast and the brain. Structurally, progranulin consists of seven-and-a-half tandem repeats of the granulin/epithelin module (GEM), several of which have been isolated as discrete 6-kDa GEM peptides. We have expressed all seven human GEMs using recombinant DNA in Escherichia coli. High-resolution NMR showed that only the three GEMs, hGrnA, hGrnC, and hGrnF, contain relatively well-defined three-dimensional structures in solution, while others are mainly mixtures of poorly structured disulfide isomers. The three-dimensional structures of hGrnA, hGrnC, and hGrnF contain a stable stack of two beta-hairpins in their N-terminal subdomains, but showed a more flexible C-terminal subdomain. Interestingly, of the well-structured GEMs, hGrnA demonstrated potent growth inhibition of a breast cancer cell line, while hGrnF was stimulatory. Poorly folded peptides were either weakly inhibitory or without activity. The functionally active and structurally well-characterized human hGrnA offers a unique opportunity for detailed structure-function studies of these important GEM proteins as novel members of mammalian growth factors.

-	~~==About this~~ Structure==	+	Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities.,Tolkatchev D, Malik S, Vinogradova A, Wang P, Chen Z, Xu P, Bennett HP, Bateman A, Ni F Protein Sci. 2008 Apr;17(4):711-24. PMID:18359860<ref>PMID:18359860</ref>
-	~~[[2jyt]] is a 1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018359860</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]

OCA at 11:18, 24 March 2013

OCA — Sun, 24 Mar 2013 11:18:00 GMT

←Older revision		Revision as of 11:18, 24 March 2013
Line 1:		Line 1:
-	[[Image:2jyt.png\|left\|200px]]
-
	{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}		{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}
-
	===Human Granulin C, isomer 1===		===Human Granulin C, isomer 1===
		+	{{ABSTRACT_PUBMED_18359860}}

-	~~{{ABSTRACT_PUBMED_18359860}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:[http://omim.org/entry/607485 607485]]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.<ref>PMID:16862116</ref><ref>PMID:16983685</ref><ref>PMID:18183624</ref> Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:[http://omim.org/entry/614706 614706]]. A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.<ref>PMID:22608501</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GRN_HUMAN GRN_HUMAN]] Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018359860</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018359860</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]

OCA: Protected "2jyt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:09:38 GMT

Protected "2jyt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:09, 7 January 2013

OCA at 11:09, 7 January 2013

OCA — Mon, 07 Jan 2013 11:09:35 GMT

←Older revision		Revision as of 11:09, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jyt.png\|left\|200px]]		[[Image:2jyt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jyt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}		{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}

	===Human Granulin C, isomer 1===		===Human Granulin C, isomer 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18359860}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18359860 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18359860}}		{{ABSTRACT_PUBMED_18359860}}
-
-	==Disease==
-	Known disease associated with this structure: Frontotemporal lobar degeneration with ubiquitin-positive inclusions OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138945 138945]]

	==About this Structure==		==About this Structure==
-	~~2JYT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].	+	[[2jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18359860~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018359860</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
Line 33:		Line 18:
	[[Category: Wang, P.]]		[[Category: Wang, P.]]
	[[Category: Xu, P.]]		[[Category: Xu, P.]]
-	[[Category: Alternative splicing]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Epithelin]]		[[Category: Epithelin]]
Line 39:		Line 23:
	[[Category: Granulin c]]		[[Category: Granulin c]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Stack of hairpin]]		[[Category: Stack of hairpin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:57:00 2009''

OCA at 18:57, 17 February 2009

OCA — Tue, 17 Feb 2009 18:57:01 GMT

←Older revision		Revision as of 18:57, 17 February 2009
Line 23:		Line 23:

	==About this Structure==		==About this Structure==
-	2JYT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].	+	2JYT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].

	==Reference==		==Reference==
-	Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities., Tolkatchev D, Malik S, Vinogradova A, Wang P, Chen Z, Xu P, Bennett HP, Bateman A, Ni F, Protein Sci. 2008 Apr;17(4):711-24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18359860 18359860]~~	+	<ref group="xtra">PMID:18359860</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
	[[Category: Ni, F.]]		[[Category: Ni, F.]]
Line 44:		Line 43:
	[[Category: Stack of hairpin]]		[[Category: Stack of hairpin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:56:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:57:00 2009''

OCA at 01:56, 29 July 2008

OCA — Tue, 29 Jul 2008 01:56:51 GMT

←Older revision		Revision as of 01:56, 29 July 2008
Line 1:		Line 1:
-	[[Image:2jyt.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2jyt.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}		{{STRUCTURE_2jyt\| PDB=2jyt \| SCENE= }}

-	~~'''~~Human Granulin C, isomer 1~~'''~~	+	===Human Granulin C, isomer 1===


-	~~==Overview==~~	+	<!--
-	~~Progranulin is a secreted protein with important functions in several physiological and pathological processes~~, ~~such as embryonic development~~, ~~host defense, and wound repair. Autosomal dominant mutations in~~ the ~~progranulin gene cause frontotemporal dementia, while overexpression of progranulin promotes~~ the ~~invasive progression of a range of tumors, including those of the breast and the brain. Structurally, progranulin consists of seven-and-a-half tandem repeats of the granulin/epithelin module~~ (~~GEM), several of which have been isolated~~ as ~~discrete 6-kDa GEM peptides~~. ~~We have expressed all seven human GEMs using recombinant DNA in Escherichia coli~~. ~~High-resolution NMR showed that only the three GEMs~~, hGrnA, hGrnC, and hGrnF, contain relatively well-defined three-dimensional structures in solution, while others are mainly mixtures of poorly structured disulfide isomers. The three-dimensional structures of hGrnA, hGrnC, and hGrnF contain a stable stack of two beta-hairpins in their N-terminal subdomains, but showed a more flexible C-terminal subdomain. Interestingly, of the ~~well-structured GEMs, hGrnA demonstrated potent growth inhibition of a breast cancer cell line, while hGrnF was stimulatory~~. ~~Poorly folded peptides were either weakly inhibitory or without activity. The functionally active and structurally well~~-~~characterized human hGrnA offers a unique opportunity for detailed structure~~-~~function studies of these important GEM proteins as novel members of mammalian growth factors.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18359860}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18359860 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18359860}}

	==Disease==		==Disease==
Line 19:		Line 23:

	==About this Structure==		==About this Structure==
-	2JYT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].	+	2JYT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYT OCA].

	==Reference==		==Reference==
Line 39:		Line 43:
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Stack of hairpin]]		[[Category: Stack of hairpin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 24 09~~:37:47 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:56:48 2008''