2jzv - Revision history

OCA at 19:08, 29 May 2024

OCA — Wed, 29 May 2024 19:08:03 GMT

←Older revision		Revision as of 19:08, 29 May 2024
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	==Solution structure of S. aureus PrsA-PPIase==		==Solution structure of S. aureus PrsA-PPIase==
-	<StructureSection load='2jzv' size='340' side='right'caption='[[2jzv~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>	+	<StructureSection load='2jzv' size='340' side='right'caption='[[2jzv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZV FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>prsA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1280~~ "~~Micrococcus aureus~~" ~~(Rosenbach 1884) Zopf 1885])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [https://pdbe.org/2jzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [https://www.ebi.ac.uk/pdbsum/2jzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [https://pdbe.org/2jzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [https://www.ebi.ac.uk/pdbsum/2jzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRSA_STAAM PRSA_STAAM]] Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).	+	[https://www.uniprot.org/uniprot/PRSA_STAAM PRSA_STAAM] Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Peptidylprolyl isomerase]]
-	[[Category: Heikkinen, S]]
-	[[Category: Kontinen, V]]
-	[[Category: Koskela, H]]
-	[[Category: Permi, P]]
-	[[Category: Seppala, R]]
-	[[Category: Tossavainen, H]]
-	[[Category: Foldase]]
-	[[Category: Isomerase]]
-	[[Category: Lipoprotein]]
-	[[Category: Membrane]]
-	[[Category: Palmitate]]
-	[[Category: Parvulin]]
-	[[Category: Ppiase]]
-	[[Category: Proline isomerase]]
-	[[Category: Rotamase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
		+	[[Category: Heikkinen S]]
		+	[[Category: Kontinen V]]
		+	[[Category: Koskela H]]
		+	[[Category: Permi P]]
		+	[[Category: Seppala R]]
		+	[[Category: Tossavainen H]]

OCA at 08:04, 7 April 2021

OCA — Wed, 07 Apr 2021 08:04:04 GMT

←Older revision		Revision as of 08:04, 7 April 2021
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	==Solution structure of S. aureus PrsA-PPIase==		==Solution structure of S. aureus PrsA-PPIase==
-	<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>	+	<StructureSection load='2jzv' size='340' side='right'caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [~~http~~://pdbe.org/2jzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [https://pdbe.org/2jzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [https://www.ebi.ac.uk/pdbsum/2jzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRSA_STAAM PRSA_STAAM]] Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).	+	[[https://www.uniprot.org/uniprot/PRSA_STAAM PRSA_STAAM]] Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Heikkinen, S]]		[[Category: Heikkinen, S]]

OCA at 10:50, 18 July 2018

OCA — Wed, 18 Jul 2018 10:50:48 GMT

←Older revision		Revision as of 10:50, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of S. aureus PrsA-PPIase==		==Solution structure of S. aureus PrsA-PPIase==
	<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://pdbe.org/2jzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://pdbe.org/2jzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:16, 9 February 2016

OCA — Tue, 09 Feb 2016 15:16:25 GMT

←Older revision		Revision as of 15:16, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jzv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:29, 10 September 2015

OCA — Thu, 10 Sep 2015 23:29:38 GMT

←Older revision		Revision as of 23:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JZV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://pdbe.org/2jzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jzv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Staphylococcus aureus]]
	[[Category: Heikkinen, S]]		[[Category: Heikkinen, S]]
	[[Category: Kontinen, V]]		[[Category: Kontinen, V]]
Line 48:		Line 48:
	[[Category: Proline isomerase]]		[[Category: Proline isomerase]]
	[[Category: Rotamase]]		[[Category: Rotamase]]
		+	[[Category: Staphylococcus aureus]]

OCA at 07:39, 25 December 2014

OCA — Thu, 25 Dec 2014 07:39:32 GMT

←Older revision		Revision as of 07:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JZV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JZV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRSA_STAAM PRSA_STAAM]] Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Heikkinen, S.]]	+	[[Category: Heikkinen, S]]
-	[[Category: Kontinen, V.]]	+	[[Category: Kontinen, V]]
-	[[Category: Koskela, H.]]	+	[[Category: Koskela, H]]
-	[[Category: Permi, P.]]	+	[[Category: Permi, P]]
-	[[Category: Seppala, R.]]	+	[[Category: Seppala, R]]
-	[[Category: Tossavainen, H.]]	+	[[Category: Tossavainen, H]]
	[[Category: Foldase]]		[[Category: Foldase]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
Line 46:		Line 48:
	[[Category: Proline isomerase]]		[[Category: Proline isomerase]]
	[[Category: Rotamase]]		[[Category: Rotamase]]
-	[[Category: Staphylococcus aureus]]

OCA at 08:49, 30 September 2014

OCA — Tue, 30 Sep 2014 08:49:48 GMT

←Older revision		Revision as of 08:49, 30 September 2014
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-	[[~~Image~~:2jzv.~~png\|left~~\|200px]]	+	==Solution structure of S. aureus PrsA-PPIase==
		+	<StructureSection load='2jzv' size='340' side='right' caption='[[2jzv]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JZV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jzv RCSB], [http://www.ebi.ac.uk/pdbsum/2jzv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Staphylococcus aureus is a Gram-positive pathogenic bacterium causing many kinds of infections from mild respiratory tract infections to life-threatening states as sepsis. Recent emergence of S. aureus strains resistant to numerous antibiotics has created a need for new antimicrobial agents and novel drug targets. S. aureus PrsA is a membrane associated extra-cytoplasmic lipoprotein which contains a parvulin-type peptidyl-prolyl cis-trans isomerase domain. PrsA is known to act as an essential folding factor for secreted proteins in Gram-positive bacteria and thus it is a potential target for antimicrobial drugs against S. aureus. RESULTS: We have solved a high-resolution solution structure of the parvulin-type peptidyl-prolyl cis-trans isomerase domain of S. aureus PrsA (PrsA-PPIase). The results of substrate peptide titrations pinpoint the active site and demonstrate the substrate preference of the enzyme. With detailed NMR spectroscopic investigation of the orientation and tautomeric state of the active site histidines we are able to give further insight into the structure of the catalytic site. NMR relaxation analysis gives information on the dynamic behaviour of PrsA-PPIase. CONCLUSION: Detailed structural description of the S. aureus PrsA-PPIase lays the foundation for structure-based design of enzyme inhibitors. The structure resembles hPin1-type parvulins both structurally and regarding substrate preference. Even though a wealth of structural data is available on parvulins, the catalytic mechanism has yet to be resolved. The structure of S. aureus PrsA-PPIase and our findings on the role of the conserved active site histidines help in designing further experiments to solve the detailed catalytic mechanism.

-	~~{{STRUCTURE_2jzv\| PDB=2jzv \| SCENE= }}~~	+	Solution structure of the parvulin-type PPIase domain of Staphylococcus aureus PrsA--implications for the catalytic mechanism of parvulins.,Heikkinen O, Seppala R, Tossavainen H, Heikkinen S, Koskela H, Permi P, Kilpelainen I BMC Struct Biol. 2009 Mar 24;9:17. PMID:19309529<ref>PMID:19309529</ref>

-	~~===Solution structure~~ of S. ~~aureus PrsA-PPIase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19309529}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jzv]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019309529<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA: Protected "2jzv" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:10:24 GMT

Protected "2jzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:10, 7 January 2013

OCA at 11:10, 7 January 2013

OCA — Mon, 07 Jan 2013 11:10:21 GMT

←Older revision		Revision as of 11:10, 7 January 2013
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-	{{Seed}}
	[[Image:2jzv.png\|left\|200px]]		[[Image:2jzv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jzv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jzv\| PDB=2jzv \| SCENE= }}		{{STRUCTURE_2jzv\| PDB=2jzv \| SCENE= }}

	===Solution structure of S. aureus PrsA-PPIase===		===Solution structure of S. aureus PrsA-PPIase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19309529}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19309529 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19309529}}		{{ABSTRACT_PUBMED_19309529}}

	==About this Structure==		==About this Structure==
-	~~2JZV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA].	+	[[2jzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19309529~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019309529</ref><references group="xtra"/>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
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	[[Category: Tossavainen, H.]]		[[Category: Tossavainen, H.]]
	[[Category: Foldase]]		[[Category: Foldase]]
		+	[[Category: Isomerase]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
	[[Category: Membrane]]		[[Category: Membrane]]
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	[[Category: Rotamase]]		[[Category: Rotamase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:24:24 2009''

OCA at 12:24, 2 April 2009

OCA — Thu, 02 Apr 2009 12:24:25 GMT

←Older revision		Revision as of 12:24, 2 April 2009
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	{{Seed}}		{{Seed}}
-	[[Image:2jzv.~~jpg~~\|left\|200px]]	+	[[Image:2jzv.png\|left\|200px]]

	<!--		<!--
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	===Solution structure of S. aureus PrsA-PPIase===		===Solution structure of S. aureus PrsA-PPIase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19309529}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19309529 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19309529}}

	==About this Structure==		==About this Structure==
	2JZV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA].		2JZV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19309529</ref><references group="xtra"/>
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
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	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 21 10~~:34:57 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:24:24 2009''