2k2n - Revision history

OCA at 07:31, 27 January 2022

OCA — Thu, 27 Jan 2022 07:31:07 GMT

←Older revision		Revision as of 07:31, 27 January 2022
Line 3:		Line 3:
	<StructureSection load='2k2n' size='340' side='right'caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2k2n' size='340' side='right'caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Synr3 Synr3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2K2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synr3 Synr3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [~~http~~://pdbe.org/2k2n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2n ProSAT], [~~http~~://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [https://pdbe.org/2k2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [https://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2n ProSAT], [https://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:30, 22 April 2020

OCA — Wed, 22 Apr 2020 06:30:59 GMT

←Older revision		Revision as of 06:30, 22 April 2020
Line 1:		Line 1:

	==Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state==		==Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state==
-	<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2k2n' size='340' side='right'caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synr3 Synr3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2K2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synr3 Synr3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2K2N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://pdbe.org/2k2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2n ProSAT], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://pdbe.org/2k2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2n ProSAT], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
		+	[[Category: Large Structures]]
	[[Category: Synr3]]		[[Category: Synr3]]
	[[Category: Cornilescu, C C]]		[[Category: Cornilescu, C C]]

OCA at 11:17, 18 July 2018

OCA — Wed, 18 Jul 2018 11:17:09 GMT

←Older revision		Revision as of 11:17, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state==		==Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state==
	<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://pdbe.org/2k2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://pdbe.org/2k2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2n ProSAT], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:13, 9 February 2016

OCA — Tue, 09 Feb 2016 05:13:53 GMT

←Older revision		Revision as of 05:13, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:58, 10 September 2015

OCA — Thu, 10 Sep 2015 18:58:24 GMT

←Older revision		Revision as of 18:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_sp. Synechococcus sp.~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K2N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synr3 Synr3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K2N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://pdbe.org/2k2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2k2n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
-	[[Category: ~~Synechococcus sp~~]]	+	[[Category: Synr3]]
	[[Category: Cornilescu, C C]]		[[Category: Cornilescu, C C]]
	[[Category: Cornilescu, G]]		[[Category: Cornilescu, G]]

OCA at 18:38, 19 January 2015

OCA — Mon, 19 Jan 2015 18:38:02 GMT

←Older revision		Revision as of 18:38, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K2N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
-	[[Category: Synechococcus sp.]]	+	[[Category: Synechococcus sp]]
-	[[Category: Cornilescu, C C.]]	+	[[Category: Cornilescu, C C]]
-	[[Category: Cornilescu, G.]]	+	[[Category: Cornilescu, G]]
-	[[Category: Markley, J L.]]	+	[[Category: Markley, J L]]
-	[[Category: Ulijasz, A T.]]	+	[[Category: Ulijasz, A T]]
-	[[Category: Vierstra, R D.]]	+	[[Category: Vierstra, R D]]
	[[Category: Bacteriophytochrome]]		[[Category: Bacteriophytochrome]]
	[[Category: Cyanobacterial phytochrome]]		[[Category: Cyanobacterial phytochrome]]

OCA at 10:55, 30 September 2014

OCA — Tue, 30 Sep 2014 10:55:39 GMT

←Older revision		Revision as of 10:55, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2k2n.~~png\|left~~\|200px]]	+	==Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state==
		+	<StructureSection load='2k2n' size='340' side='right' caption='[[2k2n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K2N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k2n RCSB], [http://www.ebi.ac.uk/pdbsum/2k2n PDBsum], [http://www.topsan.org/Proteins/CESG/2k2n TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The unique photochromic absorption behavior of phytochromes (Phys) depends on numerous reversible interactions between the bilin chromophore and the associated polypeptide. To help define these dynamic interactions, we determined by NMR spectroscopy the first solution structure of the chromophore-binding cGMP phosphodiesterase/adenylcyclase/FhlA (GAF) domain from a cyanobacterial Phy assembled with phycocyanobilin (PCB). The three-dimensional NMR structure of Synechococcus OS-B' cyanobacterial Phy 1 in the red-light-absorbing state of Phy (Pr) revealed that PCB is bound to Cys138 of the GAF domain via the A-ring ethylidene side chain and is buried within the GAF domain in a ZZZsyn,syn,anti configuration. The D ring of the chromophore sits within a hydrophobic pocket and is tilted by approximately 80 degrees relative to the B/C rings by contacts with Lys52 and His169. The solution structure revealed remarkable flexibility for PCB and several adjacent amino acids, indicating that the Pr chromophore has more freedom in the binding pocket than anticipated. The propionic acid side chains of rings B and C and Arg101 and Arg133 nearby are especially mobile and can assume several distinct and energetically favorable conformations. Mutagenic studies on these arginines, which are conserved within the Phy superfamily, revealed that they have opposing roles, with Arg101 and Arg133 helping stabilize and destabilize the far-red-light-absorbing state of Phy (Pfr), respectively. Given the fact that the Synechococcus OS-B' GAF domain can, by itself, complete the Pr --> Pfr photocycle, it should now be possible to determine the solution structure of the Pfr chromophore and surrounding pocket using this Pr structure as a framework.

-	~~{{STRUCTURE_2k2n\| PDB=2k2n \| SCENE= }}~~	+	Solution structure of a cyanobacterial phytochrome GAF domain in the red-light-absorbing ground state.,Cornilescu G, Ulijasz AT, Cornilescu CC, Markley JL, Vierstra RD J Mol Biol. 2008 Nov 7;383(2):403-13. Epub 2008 Aug 22. PMID:18762196<ref>PMID:18762196</ref>

-	~~===Solution structure~~ of ~~a cyanobacterial phytochrome GAF domain in~~ the ~~red light-absorbing ground state===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18762196}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2k2n]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_sp~~. ~~Synechococcus sp.]. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018762196<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
	[[Category: Synechococcus sp.]]		[[Category: Synechococcus sp.]]

OCA: Protected "2k2n" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:42:25 GMT

Protected "2k2n" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 7 January 2013

OCA at 12:42, 7 January 2013

OCA — Mon, 07 Jan 2013 12:42:22 GMT

←Older revision		Revision as of 12:42, 7 January 2013
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-	{{Seed}}
	[[Image:2k2n.png\|left\|200px]]		[[Image:2k2n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2k2n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2k2n\| PDB=2k2n \| SCENE= }}		{{STRUCTURE_2k2n\| PDB=2k2n \| SCENE= }}

	===Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state===		===Solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18762196}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18762196 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18762196}}		{{ABSTRACT_PUBMED_18762196}}

	==About this Structure==		==About this Structure==
-	~~2K2N~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA].	+	[[2k2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18762196~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018762196</ref><references group="xtra"/>
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
	[[Category: Synechococcus sp.]]		[[Category: Synechococcus sp.]]
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	[[Category: Phytochrome]]		[[Category: Phytochrome]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:16:04 2009''

OCA at 19:11, 10 June 2009

OCA — Wed, 10 Jun 2009 19:11:53 GMT

←Older revision		Revision as of 19:11, 10 June 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2K2N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA].	+	2K2N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2N OCA].

	==Reference==		==Reference==
Line 41:		Line 41:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 06~~:45:19 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:16:04 2009''