2kcj - Revision history

OCA at 09:37, 22 May 2024

OCA — Wed, 22 May 2024 09:37:30 GMT

←Older revision		Revision as of 09:37, 22 May 2024
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	==solution structure of FAPP1 PH domain==		==solution structure of FAPP1 PH domain==
-	<StructureSection load='2kcj' size='340' side='right'caption='[[2kcj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kcj' size='340' side='right'caption='[[2kcj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PLEKHA3, FAPP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [https://pdbe.org/2kcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [https://www.ebi.ac.uk/pdbsum/2kcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [https://pdbe.org/2kcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [https://www.ebi.ac.uk/pdbsum/2kcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PKHA3_HUMAN PKHA3_HUMAN]] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).<ref>PMID:15107860</ref>	+	[https://www.uniprot.org/uniprot/PKHA3_HUMAN PKHA3_HUMAN] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).<ref>PMID:15107860</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coskun, U]]	+	[[Category: Coskun U]]
-	[[Category: James, J]]	+	[[Category: James J]]
-	[[Category: Lenoir, M]]	+	[[Category: Lenoir M]]
-	[[Category: Overduin, M]]	+	[[Category: Overduin M]]
-	[[Category: Simons, K]]	+	[[Category: Simons K]]
-	~~[[Category: Fapp1]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Ph domain~~]]	+

OCA at 08:16, 7 April 2021

OCA — Wed, 07 Apr 2021 08:16:55 GMT

←Older revision		Revision as of 08:16, 7 April 2021
Line 1:		Line 1:

	==solution structure of FAPP1 PH domain==		==solution structure of FAPP1 PH domain==
-	<StructureSection load='2kcj' size='340' side='right' caption='[[2kcj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kcj' size='340' side='right'caption='[[2kcj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [~~http~~://pdbe.org/2kcj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kcj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [https://pdbe.org/2kcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [https://www.ebi.ac.uk/pdbsum/2kcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PKHA3_HUMAN PKHA3_HUMAN]] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).<ref>PMID:15107860</ref>	+	[[https://www.uniprot.org/uniprot/PKHA3_HUMAN PKHA3_HUMAN]] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).<ref>PMID:15107860</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Coskun, U]]		[[Category: Coskun, U]]
	[[Category: James, J]]		[[Category: James, J]]

OCA at 10:26, 18 July 2018

OCA — Wed, 18 Jul 2018 10:26:14 GMT

←Older revision		Revision as of 10:26, 18 July 2018
Line 1:		Line 1:
		+
	==solution structure of FAPP1 PH domain==		==solution structure of FAPP1 PH domain==
	<StructureSection load='2kcj' size='340' side='right' caption='[[2kcj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kcj' size='340' side='right' caption='[[2kcj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://pdbe.org/2kcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://pdbe.org/2kcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/2kcj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/2kcj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:32, 8 February 2016

OCA — Mon, 08 Feb 2016 21:32:39 GMT

←Older revision		Revision as of 21:32, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kcj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:34, 10 September 2015

OCA — Thu, 10 Sep 2015 15:34:57 GMT

←Older revision		Revision as of 15:34, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://pdbe.org/2kcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kcj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:17, 25 December 2014

OCA — Thu, 25 Dec 2014 02:17:20 GMT

←Older revision		Revision as of 02:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PKHA3_HUMAN PKHA3_HUMAN]] Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).<ref>PMID:15107860</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Coskun, U.]]	+	[[Category: Coskun, U]]
-	[[Category: James, J.]]	+	[[Category: James, J]]
-	[[Category: Lenoir, M.]]	+	[[Category: Lenoir, M]]
-	[[Category: Overduin, M.]]	+	[[Category: Overduin, M]]
-	[[Category: Simons, K.]]	+	[[Category: Simons, K]]
	[[Category: Fapp1]]		[[Category: Fapp1]]
	[[Category: Lipid-binding]]		[[Category: Lipid-binding]]

OCA at 11:35, 3 October 2014

OCA — Fri, 03 Oct 2014 11:35:00 GMT

←Older revision		Revision as of 11:35, 3 October 2014
Line 22:		Line 22:
	Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains.,Lenoir M, Coskun U, Grzybek M, Cao X, Buschhorn SB, James J, Simons K, Overduin M EMBO Rep. 2010 Apr;11(4):279-84. doi: 10.1038/embor.2010.28. Epub 2010 Mar 19. PMID:20300118<ref>PMID:20300118</ref>		Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains.,Lenoir M, Coskun U, Grzybek M, Cao X, Buschhorn SB, James J, Simons K, Overduin M EMBO Rep. 2010 Apr;11(4):279-84. doi: 10.1038/embor.2010.28. Epub 2010 Mar 19. PMID:20300118<ref>PMID:20300118</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 06:54, 28 May 2014

OCA — Wed, 28 May 2014 06:54:51 GMT

←Older revision		Revision as of 06:54, 28 May 2014
Line 1:		Line 1:
-	[[~~Image~~:2kcj.~~png\|left~~\|200px]]	+	==solution structure of FAPP1 PH domain==
		+	<StructureSection load='2kcj' size='340' side='right' caption='[[2kcj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KCJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA3, FAPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kcj RCSB], [http://www.ebi.ac.uk/pdbsum/2kcj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/2kcj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mechanisms underlying Golgi targeting and vesiculation are unknown, although the responsible phosphatidylinositol 4-phosphate (PtdIns(4)P) ligand and four-phosphate-adaptor protein (FAPP) modules have been defined. The micelle-bound structure of the FAPP1 pleckstrin homology domain reveals how its prominent wedge independently tubulates Golgi membranes by leaflet penetration. Mutations compromising the exposed hydrophobicity of full-length FAPP2 abolish lipid monolayer binding and compression. The trafficking process begins with an electrostatic approach, phosphoinositide sampling and perpendicular penetration. Extensive protein contacts with PtdIns(4)P and neighbouring phospholipids reshape the bilayer and initiate tubulation through a conserved wedge with features shared by diverse protein modules.

-	~~{{STRUCTURE_2kcj\| PDB=2kcj \| SCENE= }}~~	+	Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains.,Lenoir M, Coskun U, Grzybek M, Cao X, Buschhorn SB, James J, Simons K, Overduin M EMBO Rep. 2010 Apr;11(4):279-84. doi: 10.1038/embor.2010.28. Epub 2010 Mar 19. PMID:20300118<ref>PMID:20300118</ref>

-	~~===solution structure~~ of ~~FAPP1 PH domain===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	==~~About this Structure~~==	+	<references/>
-	~~[[2kcj]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA].~~	+	__TOC__
-	[[Category: ~~Homo sapiens~~]]	+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Coskun, U.]]		[[Category: Coskun, U.]]
	[[Category: James, J.]]		[[Category: James, J.]]

OCA: Protected "2kcj" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:57:26 GMT

Protected "2kcj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:57, 7 January 2013

OCA at 14:57, 7 January 2013

OCA — Mon, 07 Jan 2013 14:57:21 GMT

←Older revision		Revision as of 14:57, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2kcj.png\|left\|200px]]
-	[[Image:2kcj.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kcj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2kcj\| PDB=2kcj \| SCENE= }}		{{STRUCTURE_2kcj\| PDB=2kcj \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2KCJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA].	+	[[2kcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCJ OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coskun, U.]]		[[Category: Coskun, U.]]
Line 21:		Line 14:
	[[Category: Overduin, M.]]		[[Category: Overduin, M.]]
	[[Category: Simons, K.]]		[[Category: Simons, K.]]
-	[[Category: Cytoplasm]]
	[[Category: Fapp1]]		[[Category: Fapp1]]
	[[Category: Lipid-binding]]		[[Category: Lipid-binding]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
-	[[Category: Nmr]]
	[[Category: Ph domain]]		[[Category: Ph domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:59:40 2009''