2ke4 - Revision history

OCA at 05:36, 15 May 2024

OCA — Wed, 15 May 2024 05:36:15 GMT

←Older revision		Revision as of 05:36, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:44, 14 June 2023

OCA — Wed, 14 Jun 2023 08:44:15 GMT

←Older revision		Revision as of 08:44, 14 June 2023
Line 1:		Line 1:

	==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==		==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==
-	<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN]] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>	+	[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inagaki, F]]	+	[[Category: Inagaki F]]
-	[[Category: Kanoh, D]]	+	[[Category: Kanoh D]]
-	[[Category: Kobashigawa, Y]]	+	[[Category: Kobashigawa Y]]
-	[[Category: Kumeta, H]]	+	[[Category: Kumeta H]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cdc42]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cip4]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Lysosome]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Tc10~~]]	+

OCA at 07:04, 1 December 2021

OCA — Wed, 01 Dec 2021 07:04:39 GMT

←Older revision		Revision as of 07:04, 1 December 2021
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	<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [~~http~~://pdbe.org/2ke4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN]] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>	+	[[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN]] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:34, 26 February 2020

OCA — Wed, 26 Feb 2020 09:34:30 GMT

←Older revision		Revision as of 09:34, 26 February 2020
Line 1:		Line 1:

	==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==		==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==
-	<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kanoh, D]]		[[Category: Kanoh, D]]

OCA at 11:08, 18 July 2018

OCA — Wed, 18 Jul 2018 11:08:56 GMT

←Older revision		Revision as of 11:08, 18 July 2018
Line 1:		Line 1:
		+
	==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==		==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==
	<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://pdbe.org/2ke4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://pdbe.org/2ke4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ke4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ke4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	[[Category: Kobashigawa, Y]]		[[Category: Kobashigawa, Y]]
	[[Category: Kumeta, H]]		[[Category: Kumeta, H]]
		+	[[Category: Alternative splicing]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Cip4]]		[[Category: Cip4]]
		+	[[Category: Coiled coil]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]

OCA at 13:45, 8 February 2016

OCA — Mon, 08 Feb 2016 13:45:14 GMT

←Older revision		Revision as of 13:45, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ke4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 12:08, 10 September 2015

OCA — Thu, 10 Sep 2015 12:08:20 GMT

←Older revision		Revision as of 12:08, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://pdbe.org/2ke4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kanoh, D]]		[[Category: Kanoh, D]]

OCA at 23:45, 24 December 2014

OCA — Wed, 24 Dec 2014 23:45:03 GMT

←Older revision		Revision as of 23:45, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN]] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Inagaki, F.]]	+	[[Category: Inagaki, F]]
-	[[Category: Kanoh, D.]]	+	[[Category: Kanoh, D]]
-	[[Category: Kobashigawa, Y.]]	+	[[Category: Kobashigawa, Y]]
-	[[Category: Kumeta, H.]]	+	[[Category: Kumeta, H]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 10:09, 30 September 2014

OCA — Tue, 30 Sep 2014 10:09:58 GMT

←Older revision		Revision as of 10:09, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2ke4.png\|left\|200px]]~~	+	==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==
-		+	<StructureSection load='2ke4' size='340' side='right' caption='[[2ke4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2ke4\| PDB=2ke4 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
-	===The NMR structure of the TC10 and Cdc42 interacting domain of CIP4===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIP10, CIP4, STOT, STP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ke4 PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2ke4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-		+	Check<jmol>
-	==~~Reference~~==	+	<jmolCheckbox>
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~019387844~~</~~ref~~><~~references group~~="~~xtra~~"/>	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ke4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inagaki, F.]]		[[Category: Inagaki, F.]]

OCA: Protected "2ke4" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:59:30 GMT

Protected "2ke4" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:59, 7 January 2013