2kg1 - Revision history

OCA at 06:45, 1 May 2024

OCA — Wed, 01 May 2024 06:45:43 GMT

←Older revision		Revision as of 06:45, 1 May 2024
Line 1:		Line 1:

	==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==		==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==
-	<StructureSection load='2kg1' size='340' side='right'caption='[[2kg1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kg1' size='340' side='right'caption='[[2kg1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [https://pdbe.org/2kg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [https://pdbe.org/2kg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN]] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>	+	[https://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The heterogeneous nuclear ribonucleoprotein (hnRNP) F is involved in the regulation of mRNA metabolism by specifically recognizing G-tract RNA sequences. We have determined the solution structures of the three quasi-RNA-recognition motifs (qRRMs) of hnRNP F in complex with G-tract RNA. These structures show that qRRMs bind RNA in a very unusual manner, with the G-tract 'encaged', making the qRRM a novel RNA binding domain. We defined a consensus signature sequence for qRRMs and identified other human qRRM-containing proteins that also specifically recognize G-tract RNAs. Our structures explain how qRRMs can sequester G-tracts, maintaining them in a single-stranded conformation. We also show that isolated qRRMs of hnRNP F are sufficient to regulate the alternative splicing of the Bcl-x pre-mRNA, suggesting that hnRNP F would act by remodeling RNA secondary and tertiary structures.
-
-	Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.,Dominguez C, Fisette JF, Chabot B, Allain FH Nat Struct Mol Biol. 2010 Jul;17(7):853-61. Epub 2010 Jun 6. PMID:20526337<ref>PMID:20526337</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2kg1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allain~~, F H.T~~]]	+	[[Category: Allain FHT]]
-	[[Category: Dominguez, C]]	+	[[Category: Dominguez C]]
-	~~[[Category: G tract]]~~	+
-	~~[[Category: Mrna processing]]~~	+
-	~~[[Category: Mrna splicing]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polyadenylation regulation]]~~	+
-	~~[[Category: Protein-rna complex]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Rna binding protein-rna complex]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Spliceosome]]~~	+
-	~~[[Category: Splicing regulation~~]]	+

OCA at 07:04, 1 December 2021

OCA — Wed, 01 Dec 2021 07:04:50 GMT

←Older revision		Revision as of 07:04, 1 December 2021
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	<StructureSection load='2kg1' size='340' side='right'caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kg1' size='340' side='right'caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [~~http~~://pdbe.org/2kg1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kg1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [https://pdbe.org/2kg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN]] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>	+	[[https://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN]] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:35, 26 February 2020

OCA — Wed, 26 Feb 2020 09:35:01 GMT

←Older revision		Revision as of 09:35, 26 February 2020
Line 1:		Line 1:

	==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==		==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==
-	<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kg1' size='340' side='right'caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Dominguez, C]]		[[Category: Dominguez, C]]

OCA at 11:07, 18 July 2018

OCA — Wed, 18 Jul 2018 11:07:37 GMT

←Older revision		Revision as of 11:07, 18 July 2018
Line 1:		Line 1:
		+
	==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==		==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==
	<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://pdbe.org/2kg1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://pdbe.org/2kg1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:18, 9 September 2015

OCA — Wed, 09 Sep 2015 22:18:57 GMT

←Older revision		Revision as of 22:18, 9 September 2015
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	<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://pdbe.org/2kg1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kg1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Dominguez, C]]		[[Category: Dominguez, C]]

OCA at 08:13, 24 December 2014

OCA — Wed, 24 Dec 2014 08:13:47 GMT

←Older revision		Revision as of 08:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN]] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Allain, F H.T.]]	+	[[Category: Allain, F H.T]]
-	[[Category: Dominguez, C.]]	+	[[Category: Dominguez, C]]
	[[Category: G tract]]		[[Category: G tract]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]

OCA at 03:10, 29 September 2014

OCA — Mon, 29 Sep 2014 03:10:46 GMT

←Older revision		Revision as of 03:10, 29 September 2014
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-	[[~~Image:~~2kg1.~~png~~\|~~left~~\|200px]]	+	==Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA==
		+	<StructureSection load='2kg1' size='340' side='right' caption='[[2kg1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KG1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgn\|2hgn]], [[2kfy\|2kfy]], [[2kg0\|2kg0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kg1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heterogeneous nuclear ribonucleoprotein (hnRNP) F is involved in the regulation of mRNA metabolism by specifically recognizing G-tract RNA sequences. We have determined the solution structures of the three quasi-RNA-recognition motifs (qRRMs) of hnRNP F in complex with G-tract RNA. These structures show that qRRMs bind RNA in a very unusual manner, with the G-tract 'encaged', making the qRRM a novel RNA binding domain. We defined a consensus signature sequence for qRRMs and identified other human qRRM-containing proteins that also specifically recognize G-tract RNAs. Our structures explain how qRRMs can sequester G-tracts, maintaining them in a single-stranded conformation. We also show that isolated qRRMs of hnRNP F are sufficient to regulate the alternative splicing of the Bcl-x pre-mRNA, suggesting that hnRNP F would act by remodeling RNA secondary and tertiary structures.

-	~~{{STRUCTURE_2kg1\| PDB=2kg1 \| SCENE= }}~~	+	Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.,Dominguez C, Fisette JF, Chabot B, Allain FH Nat Struct Mol Biol. 2010 Jul;17(7):853-61. Epub 2010 Jun 6. PMID:20526337<ref>PMID:20526337</ref>

-	~~===Structure~~ of the ~~third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20526337}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2kg1]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA].~~	+

	==See Also==		==See Also==
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020526337<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.T.]]		[[Category: Allain, F H.T.]]

OCA at 05:43, 20 October 2012

OCA — Sat, 20 Oct 2012 05:43:20 GMT

←Older revision		Revision as of 05:43, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2kg1]] is a 2 chain structure ~~of [[Nucleoprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA].	+	[[2kg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA].

	==See Also==		==See Also==

OCA: Protected "2kg1" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 10:55:50 GMT

Protected "2kg1" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:55, 25 July 2012

OCA at 10:55, 25 July 2012

OCA — Wed, 25 Jul 2012 10:55:48 GMT

←Older revision		Revision as of 10:55, 25 July 2012
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-	{{Seed}}
	[[Image:2kg1.png\|left\|200px]]		[[Image:2kg1.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2kg1\| PDB=2kg1 \| SCENE= }}		{{STRUCTURE_2kg1\| PDB=2kg1 \| SCENE= }}

	===Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA===		===Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20526337}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20526337 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20526337}}		{{ABSTRACT_PUBMED_20526337}}

	==About this Structure==		==About this Structure==
-	~~2KG1~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA].	+	[[2kg1]] is a 2 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG1 OCA].
		+
		+	==See Also==
		+	*[[Nucleoprotein\|Nucleoprotein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20526337~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020526337</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.T.]]		[[Category: Allain, F H.T.]]
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	[[Category: Spliceosome]]		[[Category: Spliceosome]]
	[[Category: Splicing regulation]]		[[Category: Splicing regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 09:49:14 2010''