2kjw - Revision history

OCA at 06:46, 1 May 2024

OCA — Wed, 01 May 2024 06:46:19 GMT

←Older revision		Revision as of 06:46, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [https://pdbe.org/2kjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [https://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [https://pdbe.org/2kjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [https://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]		[https://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The ribosomal protein S6 from Thermus thermophilus has served as a model system for the study of protein folding, especially for understanding the effects of circular permutations of secondary structure elements. This study presents the structure of a permutant protein, the 96-residue P(54-55), and the structure of its 101-residue parent protein S6(wt) in solution. The data also characterizes the effects of circular permutation on the backbone dynamics of S6. Consistent with crystallographic data on S6(wt), the overall solution structures of both P(54-55) and S6(wt) show a beta-sheet of four antiparallel beta-strands with two alpha-helices packed on one side of the sheet. In clear contrast to the crystal data, however, the solution structure of S6(wt) reveals a disordered loop in the region between beta-strands 2 and 3 (Leu43-Phe60) instead of a well-ordered stretch and associated hydrophobic mini-core observed in the crystal structure. Moreover, the data for P(54-55) show that the joined wild-type N- and C-terminals form a dynamically robust stretch with a hairpin structure that complies with the in silico design. Taken together, the results explain why the loop region of the S6(wt) structure is relatively insensitive to mutational perturbations, and why P(54-55) is more stable than S6(wt): the permutant incision at Lys54-Asp55 is energetically neutral by being located in an already disordered loop whereas the new hairpin between the wild-type N- and C-termini is stabilizing.
-
-	Solution structures and backbone dynamics of the ribosomal protein S6 and its permutant P(54-55).,Ohman A, Oman T, Oliveberg M Protein Sci. 2010 Jan;19(1):183-9. PMID:19937661<ref>PMID:19937661</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribosomal protein S6\|Ribosomal protein S6]]		*[[Ribosomal protein S6\|Ribosomal protein S6]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 18 January 2023

OCA — Wed, 18 Jan 2023 08:04:04 GMT

←Older revision		Revision as of 08:04, 18 January 2023
Line 1:		Line 1:

	==Solution structure and backbone dynamics of the permutant P54-55==		==Solution structure and backbone dynamics of the permutant P54-55==
-	<StructureSection load='2kjw' size='340' side='right'caption='[[2kjw~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kjw' size='340' side='right'caption='[[2kjw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ris\|1ris]], [[2kjv\|2kjv]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [https://pdbe.org/2kjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [https://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [https://pdbe.org/2kjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [https://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~RS6_THETH RS6_THETH]~~] Located on the outer edge of the platform on the body of the 30S subunit ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ohman, A~~]]	+	[[Category: Thermus thermophilus]]
-	[[Category: ~~Oliveberg, M~~]]	+	[[Category: Ohman A]]
-	[[Category: ~~Oman, T~~]]	+	[[Category: Oliveberg M]]
-	[[Category: ~~Backbone dynamic]]~~	+	[[Category: Oman T]]
-	~~[[Category: Folding]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Ribosomal protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rrna-binding]]~~	+
-	~~[[Category: S6 permutant]]~~	+
-	~~[[Category: Solution structure~~]]	+

OCA at 07:27, 14 April 2021

OCA — Wed, 14 Apr 2021 07:27:17 GMT

←Older revision		Revision as of 07:27, 14 April 2021
Line 1:		Line 1:

	==Solution structure and backbone dynamics of the permutant P54-55==		==Solution structure and backbone dynamics of the permutant P54-55==
-	<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kjw' size='340' side='right'caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ris\|1ris]], [[2kjv\|2kjv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [~~http~~://pdbe.org/2kjw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [https://pdbe.org/2kjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [https://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).	+	[[https://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S6\|Ribosomal protein S6]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]		[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
		+	[[Category: Large Structures]]
	[[Category: Ohman, A]]		[[Category: Ohman, A]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]

OCA at 07:51, 22 November 2017

OCA — Wed, 22 Nov 2017 07:51:31 GMT

←Older revision		Revision as of 07:51, 22 November 2017
Line 1:		Line 1:
		+
	==Solution structure and backbone dynamics of the permutant P54-55==		==Solution structure and backbone dynamics of the permutant P54-55==
	<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://pdbe.org/2kjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://pdbe.org/2kjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ribosomal protein S6\|Ribosomal protein S6]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:56, 11 September 2015

OCA — Fri, 11 Sep 2015 07:56:33 GMT

←Older revision		Revision as of 07:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 ~~Thermus thermophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://pdbe.org/2kjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kjw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: Ohman, A]]		[[Category: Ohman, A]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]

OCA at 13:31, 25 December 2014

OCA — Thu, 25 Dec 2014 13:31:59 GMT

←Older revision		Revision as of 13:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Ohman, A.]]	+	[[Category: Ohman, A]]
-	[[Category: Oliveberg, M.]]	+	[[Category: Oliveberg, M]]
-	[[Category: Oman, T.]]	+	[[Category: Oman, T]]
	[[Category: Backbone dynamic]]		[[Category: Backbone dynamic]]
	[[Category: Folding]]		[[Category: Folding]]

OCA at 04:45, 29 September 2014

OCA — Mon, 29 Sep 2014 04:45:18 GMT

←Older revision		Revision as of 04:45, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2kjw.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure and backbone dynamics of the permutant P54-55==
		+	<StructureSection load='2kjw' size='340' side='right' caption='[[2kjw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ris\|1ris]], [[2kjv\|2kjv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, rps6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kjw RCSB], [http://www.ebi.ac.uk/pdbsum/2kjw PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ribosomal protein S6 from Thermus thermophilus has served as a model system for the study of protein folding, especially for understanding the effects of circular permutations of secondary structure elements. This study presents the structure of a permutant protein, the 96-residue P(54-55), and the structure of its 101-residue parent protein S6(wt) in solution. The data also characterizes the effects of circular permutation on the backbone dynamics of S6. Consistent with crystallographic data on S6(wt), the overall solution structures of both P(54-55) and S6(wt) show a beta-sheet of four antiparallel beta-strands with two alpha-helices packed on one side of the sheet. In clear contrast to the crystal data, however, the solution structure of S6(wt) reveals a disordered loop in the region between beta-strands 2 and 3 (Leu43-Phe60) instead of a well-ordered stretch and associated hydrophobic mini-core observed in the crystal structure. Moreover, the data for P(54-55) show that the joined wild-type N- and C-terminals form a dynamically robust stretch with a hairpin structure that complies with the in silico design. Taken together, the results explain why the loop region of the S6(wt) structure is relatively insensitive to mutational perturbations, and why P(54-55) is more stable than S6(wt): the permutant incision at Lys54-Asp55 is energetically neutral by being located in an already disordered loop whereas the new hairpin between the wild-type N- and C-termini is stabilizing.

-	~~{{STRUCTURE_2kjw\| PDB=2kjw \| SCENE= }}~~	+	Solution structures and backbone dynamics of the ribosomal protein S6 and its permutant P(54-55).,Ohman A, Oman T, Oliveberg M Protein Sci. 2010 Jan;19(1):183-9. PMID:19937661<ref>PMID:19937661</ref>

-	~~===Solution structure and backbone dynamics~~ of the ~~permutant P54-55===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19937661}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2kjw]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA].~~	+

	==See Also==		==See Also==
	*[[Ribosomal protein S6\|Ribosomal protein S6]]		*[[Ribosomal protein S6\|Ribosomal protein S6]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019937661<~~/~~ref~~><~~ref group="xtra">PMID:019966220</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Ohman, A.]]		[[Category: Ohman, A.]]

OCA at 17:16, 20 October 2012

OCA — Sat, 20 Oct 2012 17:16:13 GMT

←Older revision		Revision as of 17:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2kjw]] is a 1 chain structure ~~of [[Ribosomal protein S6]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA].	+	[[2kjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJW OCA].

	==See Also==		==See Also==

OCA at 00:22, 27 July 2012

OCA — Fri, 27 Jul 2012 00:22:08 GMT

←Older revision		Revision as of 00:22, 27 July 2012
Line 1:		Line 1:
	[[Image:2kjw.png\|left\|200px]]		[[Image:2kjw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kjw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kjw\| PDB=2kjw \| SCENE= }}		{{STRUCTURE_2kjw\| PDB=2kjw \| SCENE= }}

	===Solution structure and backbone dynamics of the permutant P54-55===		===Solution structure and backbone dynamics of the permutant P54-55===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19937661}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19937661 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19937661}}		{{ABSTRACT_PUBMED_19937661}}

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	==See Also==		==See Also==
-	*[[Ribosomal protein S6]]	+	*[[Ribosomal protein S6\|Ribosomal protein S6]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19937661~~</ref><ref group="xtra">PMID:~~19966220~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019937661</ref><ref group="xtra">PMID:019966220</ref><references group="xtra"/>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Ohman, A.]]		[[Category: Ohman, A.]]

OCA: Protected "2kjw" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 18:55:34 GMT

Protected "2kjw" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:55, 14 March 2011