2kkz - Revision history

OCA at 13:07, 26 July 2023

OCA — Wed, 26 Jul 2023 13:07:56 GMT

←Older revision		Revision as of 13:07, 26 July 2023
Line 1:		Line 1:

	==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==		==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==
-	<StructureSection load='2kkz' size='340' side='right'caption='[[2kkz~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kkz' size='340' side='right'caption='[[2kkz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~hungary~~/2/1971(~~h3n2~~)) Influenza a virus (a/~~hungary~~/2/1971(~~h3n2~~))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hungary/2/1971(H3N2)) Influenza A virus (A/Hungary/2/1971(H3N2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>NS, NS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~221021 Influenza A virus (A/Hungary/2/1971(H3N2))])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [https://pdbe.org/2kkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [https://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkz ProSAT], [https://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [https://pdbe.org/2kkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [https://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkz ProSAT], [https://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q6XSU2_9INFA Q6XSU2_9INFA]~~] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.~~[SAAS~~:~~SAAS00141143]~~ Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.~~[SAAS~~:~~SAAS00141179]~~	+	[https://www.uniprot.org/uniprot/NS1_I72A2 NS1_I72A2] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.<ref>PMID:9651582</ref> <ref>PMID:9560194</ref> <ref>PMID:16571812</ref> Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells (By similarity).<ref>PMID:9651582</ref> <ref>PMID:9560194</ref> <ref>PMID:16571812</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aramini~~, J M~~]]	+	[[Category: Aramini JM]]
-	[[Category: Ciccosanti, C]]	+	[[Category: Ciccosanti C]]
-	[[Category: Cunningham, K]]	+	[[Category: Cunningham K]]
-	[[Category: Fang, Y]]	+	[[Category: Fang Y]]
-	[[Category: Janjua, H]]	+	[[Category: Janjua H]]
-	[[Category: Krug~~, R M~~]]	+	[[Category: Krug RM]]
-	[[Category: Lee, H]]	+	[[Category: Lee H]]
-	[[Category: Ma, L]]	+	[[Category: Ma L]]
-	[[Category: Montelione~~, G T]]~~	+	[[Category: Montelione GT]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Xiao R]]
-	[[Category: Xiao, R]]	+	[[Category: Zhao L]]
-	[[Category: Zhao, L]]	+
-	~~[[Category: Antiviral protein]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Effector domain]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Influenza some]]~~	+
-	~~[[Category: Interferon antiviral system evasion]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Solution nmr structure]]~~	+
-	~~[[Category: W187r mutant~~]]	+

OCA at 07:27, 14 April 2021

OCA — Wed, 14 Apr 2021 07:27:40 GMT

←Older revision		Revision as of 07:27, 14 April 2021
Line 1:		Line 1:

	==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==		==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==
-	<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kkz' size='340' side='right'caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/hungary/2/1971(h3n2)) Influenza a virus (a/hungary/2/1971(h3n2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/hungary/2/1971(h3n2)) Influenza a virus (a/hungary/2/1971(h3n2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221021 Influenza A virus (A/Hungary/2/1971(H3N2))])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221021 Influenza A virus (A/Hungary/2/1971(H3N2))])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [~~http~~://pdbe.org/2kkz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkz ProSAT], [~~http~~://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [https://pdbe.org/2kkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [https://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkz ProSAT], [https://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q6XSU2_9INFA Q6XSU2_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]	+	[[https://www.uniprot.org/uniprot/Q6XSU2_9INFA Q6XSU2_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aramini, J M]]		[[Category: Aramini, J M]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 08:36, 25 July 2018

OCA — Wed, 25 Jul 2018 08:36:48 GMT

←Older revision		Revision as of 08:36, 25 July 2018
Line 1:		Line 1:
		+
	==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==		==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==
	<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hungary/2/1971(h3n2)) Influenza a virus (a/hungary/2/1971(h3n2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hungary/2/1971(h3n2)) Influenza a virus (a/hungary/2/1971(h3n2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221021 Influenza A virus (A/Hungary/2/1971(H3N2))])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221021 Influenza A virus (A/Hungary/2/1971(H3N2))])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://pdbe.org/2kkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://pdbe.org/2kkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkz ProSAT], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 24:
	[[Category: Zhao, L]]		[[Category: Zhao, L]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
		+	[[Category: Cytoplasm]]
	[[Category: Effector domain]]		[[Category: Effector domain]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]

OCA at 00:41, 11 September 2015

OCA — Fri, 11 Sep 2015 00:41:28 GMT

←Older revision		Revision as of 00:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hungary/2/1971(h3n2)) Influenza a virus (a/hungary/2/1971(h3n2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~11320~~ Influenza A virus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221021 Influenza A virus (A/Hungary/2/1971(H3N2))])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://pdbe.org/2kkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 10:		Line 10:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]
	[[Category: Aramini, J M]]		[[Category: Aramini, J M]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 08:31, 25 December 2014

OCA — Thu, 25 Dec 2014 08:31:41 GMT

←Older revision		Revision as of 08:31, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6XSU2_9INFA Q6XSU2_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Aramini, J M.]]	+	[[Category: Aramini, J M]]
-	[[Category: Ciccosanti, C.]]	+	[[Category: Ciccosanti, C]]
-	[[Category: Cunningham, K.]]	+	[[Category: Cunningham, K]]
-	[[Category: Fang, Y.]]	+	[[Category: Fang, Y]]
-	[[Category: Janjua, H.]]	+	[[Category: Janjua, H]]
-	[[Category: Krug, R M.]]	+	[[Category: Krug, R M]]
-	[[Category: Lee, H.]]	+	[[Category: Lee, H]]
-	[[Category: Ma, L.]]	+	[[Category: Ma, L]]
-	[[Category: Montelione, G T.]]	+	[[Category: Montelione, G T]]
-	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Xiao, R.]]	+	[[Category: Xiao, R]]
-	[[Category: Zhao, L.]]	+	[[Category: Zhao, L]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
	[[Category: Effector domain]]		[[Category: Effector domain]]
Line 27:		Line 29:
	[[Category: Interferon antiviral system evasion]]		[[Category: Interferon antiviral system evasion]]
	[[Category: Nesg]]		[[Category: Nesg]]
-	[[Category: ~~Northeast structural genomics consortium]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi-2~~]]	+
	[[Category: Solution nmr structure]]		[[Category: Solution nmr structure]]
-	[[Category: Structural genomic]]
	[[Category: W187r mutant]]		[[Category: W187r mutant]]

OCA at 15:39, 12 October 2014

OCA — Sun, 12 Oct 2014 15:39:11 GMT

←Older revision		Revision as of 15:39, 12 October 2014
Line 1:		Line 1:
-	~~[[Image:2kkz.png\|left\|200px]]~~	+	==Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].==
-		+	<StructureSection load='2kkz' size='340' side='right' caption='[[2kkz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2kkz\| PDB=2kkz \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKZ FirstGlance]. <br>
-	===Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].===	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS, NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kkz RCSB], [http://www.ebi.ac.uk/pdbsum/2kkz PDBsum], [http://www.topsan.org/Proteins/NESGC/2kkz TOPSAN]</span></td></tr>
-	~~{{ABSTRACT_PUBMED_021622573}}~~	+	</table>
-		+	__TOC__
-	==~~About this Structure~~==	+	</StructureSection>
-	[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA].	+
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Aramini, J M.]]		[[Category: Aramini, J M.]]

OCA: Protected "2kkz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:06:38 GMT

Protected "2kkz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:06, 7 January 2013

OCA at 12:06, 7 January 2013

OCA — Mon, 07 Jan 2013 12:06:34 GMT

←Older revision		Revision as of 12:06, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2kkz.png\|left\|200px]]
-	[[Image:2kkz.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kkz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kkz\| PDB=2kkz \| SCENE= }}		{{STRUCTURE_2kkz\| PDB=2kkz \| SCENE= }}

	===Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].===		===Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].===

		+	{{ABSTRACT_PUBMED_021622573}}

	==About this Structure==		==About this Structure==
-	~~2KKZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA].	+	[[2kkz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA].
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Aramini, J M.]]		[[Category: Aramini, J M.]]
Line 29:		Line 23:
	[[Category: Zhao, L.]]		[[Category: Zhao, L.]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
-	[[Category: Cytoplasm]]
	[[Category: Effector domain]]		[[Category: Effector domain]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
Line 41:		Line 34:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: W187r mutant]]		[[Category: W187r mutant]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:29:23 2009''

OCA at 17:29, 22 July 2009

OCA — Wed, 22 Jul 2009 17:29:25 GMT

←Older revision		Revision as of 17:29, 22 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2kkz.jpg\|left\|200px]]

-	The ~~entry 2kkz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2kkz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2kkz\| PDB=2kkz \| SCENE= }}

-	~~Authors: Aramini, J~~.~~M., Ma, L., Lee, H., Zhao, L., Cunningham, K., Ciccosanti, C., Janjua, H., Fang, Y., Xiao, R., Krug, R.M., Montelione, G.T.,~~ Northeast Structural Genomics ~~Consortium (NESG)~~	+	===Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].===

-	Description: Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~8 09~~:09:51 2009''	+	==About this Structure==
		+	2KKZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKZ OCA].
		+	[[Category: Influenza a virus]]
		+	[[Category: Aramini, J M.]]
		+	[[Category: Ciccosanti, C.]]
		+	[[Category: Cunningham, K.]]
		+	[[Category: Fang, Y.]]
		+	[[Category: Janjua, H.]]
		+	[[Category: Krug, R M.]]
		+	[[Category: Lee, H.]]
		+	[[Category: Ma, L.]]
		+	[[Category: Montelione, G T.]]
		+	[[Category: NESG, Northeast Structural Genomics Consortium.]]
		+	[[Category: Xiao, R.]]
		+	[[Category: Zhao, L.]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Effector domain]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Influenza some]]
		+	[[Category: Interferon antiviral system evasion]]
		+	[[Category: Nesg]]
		+	[[Category: Northeast structural genomics consortium]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Solution nmr structure]]
		+	[[Category: Structural genomic]]
		+	[[Category: W187r mutant]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:29:23 2009''

OCA: New page: '''Unreleased structure''' The entry 2kkz is ON HOLD Authors: Aramini, J.M., Ma, L., Lee, H., Zhao, L., Cunningham, K., Ciccosanti, C., Janjua, H., Fang, Y., Xiao, R., Krug, R.M., Monte...

OCA — Wed, 08 Jul 2009 06:09:51 GMT

New page: '''Unreleased structure''' The entry 2kkz is ON HOLD Authors: Aramini, J.M., Ma, L., Lee, H., Zhao, L., Cunningham, K., Ciccosanti, C., Janjua, H., Fang, Y., Xiao, R., Krug, R.M., Monte...

New page

'''Unreleased structure'''

The entry 2kkz is ON HOLD

Authors: Aramini, J.M., Ma, L., Lee, H., Zhao, L., Cunningham, K., Ciccosanti, C., Janjua, H., Fang, Y., Xiao, R., Krug, R.M., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)

Description: Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:09:51 2009''