2koj - Revision history

OCA at 09:40, 22 May 2024

OCA — Wed, 22 May 2024 09:40:50 GMT

←Older revision		Revision as of 09:40, 22 May 2024
Line 1:		Line 1:

	==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==		==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==
-	<StructureSection load='2koj' size='340' side='right'caption='[[2koj~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2koj' size='340' side='right'caption='[[2koj]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Par-3, Par3, Pard3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [https://pdbe.org/2koj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [https://www.ebi.ac.uk/pdbsum/2koj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2koj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [https://pdbe.org/2koj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [https://www.ebi.ac.uk/pdbsum/2koj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2koj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PARD3_MOUSE PARD3_MOUSE]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.	+	[https://www.uniprot.org/uniprot/PARD3_MOUSE PARD3_MOUSE] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Peterson FC]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Tyler RC]]
-	[[Category: Tyler~~, R C~~]]	+	[[Category: Volkman BF]]
-	[[Category: Volkman~~, B F]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cesg]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Par-3]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Tight junction~~]]	+

OCA at 07:29, 14 April 2021

OCA — Wed, 14 Apr 2021 07:29:35 GMT

←Older revision		Revision as of 07:29, 14 April 2021
Line 1:		Line 1:

	==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==		==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==
-	<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2koj' size='340' side='right'caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [~~http~~://pdbe.org/2koj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2koj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2koj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [https://pdbe.org/2koj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [https://www.ebi.ac.uk/pdbsum/2koj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2koj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PARD3_MOUSE PARD3_MOUSE]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.	+	[[https://www.uniprot.org/uniprot/PARD3_MOUSE PARD3_MOUSE]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 08:31, 25 July 2018

OCA — Wed, 25 Jul 2018 08:31:23 GMT

←Older revision		Revision as of 08:31, 25 July 2018
Line 1:		Line 1:
		+
	==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==		==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==
	<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://pdbe.org/2koj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://pdbe.org/2koj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2koj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	[[Category: Tyler, R C]]		[[Category: Tyler, R C]]
	[[Category: Volkman, B F]]		[[Category: Volkman, B F]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cesg]]		[[Category: Cesg]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 10:14, 8 February 2016

OCA — Mon, 08 Feb 2016 10:14:08 GMT

←Older revision		Revision as of 10:14, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2koj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 10:33, 10 September 2015

OCA — Thu, 10 Sep 2015 10:33:24 GMT

←Older revision		Revision as of 10:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://pdbe.org/2koj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Peterson, F C]]		[[Category: Peterson, F C]]

OCA at 22:36, 24 December 2014

OCA — Wed, 24 Dec 2014 22:36:20 GMT

←Older revision		Revision as of 22:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PARD3_MOUSE PARD3_MOUSE]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~CESG, Center for Eukaryotic~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Peterson, F C.]]	+	[[Category: Peterson, F C]]
-	[[Category: Tyler, R C.]]	+	[[Category: Tyler, R C]]
-	[[Category: Volkman, B F.]]	+	[[Category: Volkman, B F]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
-	[[Category: Center for eukaryotic structural genomic]]
	[[Category: Cesg]]		[[Category: Cesg]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
Line 33:		Line 34:
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2~~]]	+
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	[[Category: Structural genomic]]
	[[Category: Tight junction]]		[[Category: Tight junction]]

OCA at 08:17, 30 September 2014

OCA — Tue, 30 Sep 2014 08:17:03 GMT

←Older revision		Revision as of 08:17, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2koj.png\|left\|200px]]~~	+	==Solution structure of mouse Par-3 PDZ2 (residues 450-558)==
-		+	<StructureSection load='2koj' size='340' side='right' caption='[[2koj]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2koj\| PDB=2koj \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOJ FirstGlance]. <br>
-	===Solution structure of mouse Par-3 PDZ2 (residues 450-558)===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Par-3, Par3, Pard3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2koj RCSB], [http://www.ebi.ac.uk/pdbsum/2koj PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: CESG, Center for Eukaryotic Structural Genomics.]]		[[Category: CESG, Center for Eukaryotic Structural Genomics.]]

OCA: Protected "2koj" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:43:37 GMT

Protected "2koj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 7 January 2013

OCA at 10:43, 7 January 2013

OCA — Mon, 07 Jan 2013 10:43:33 GMT

←Older revision		Revision as of 10:43, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2koj.png\|left\|200px]]
-	[[Image:2koj.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2koj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2koj\| PDB=2koj \| SCENE= }}		{{STRUCTURE_2koj\| PDB=2koj \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2KOJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA].	+	[[2koj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA].
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: CESG, Center for Eukaryotic Structural Genomics.]]		[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
Line 20:		Line 13:
	[[Category: Tyler, R C.]]		[[Category: Tyler, R C.]]
	[[Category: Volkman, B F.]]		[[Category: Volkman, B F.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]
Line 26:		Line 18:
	[[Category: Center for eukaryotic structural genomic]]		[[Category: Center for eukaryotic structural genomic]]
	[[Category: Cesg]]		[[Category: Cesg]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 38:		Line 28:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Tight junction]]		[[Category: Tight junction]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:12:44 2009''

OCA at 20:12, 11 November 2009

OCA — Wed, 11 Nov 2009 20:12:47 GMT

←Older revision		Revision as of 20:12, 11 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2koj.jpg\|left\|200px]]

-	The ~~entry 2koj~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2koj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2koj\| PDB=2koj \| SCENE= }}

-	~~Authors: Volkman, B.F., Tyler, R.C., Peterson, F.C., Center for Eukaryotic Structural Genomics~~ (~~CESG~~)	+	===Solution structure of mouse Par-3 PDZ2 (residues 450-558)===

-	Description: Solution structure of mouse Par-3 PDZ2 (residues 450-558)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 14 10~~:00:20 2009''	+	==About this Structure==
		+	2KOJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOJ OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
		+	[[Category: Peterson, F C.]]
		+	[[Category: Tyler, R C.]]
		+	[[Category: Volkman, B F.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Cell junction]]
		+	[[Category: Center for eukaryotic structural genomic]]
		+	[[Category: Cesg]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Membrane]]
		+	[[Category: Par-3]]
		+	[[Category: Pdz domain]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tight junction]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:12:44 2009''