2kok - Revision history

OCA at 09:49, 9 May 2024

OCA — Thu, 09 May 2024 09:49:46 GMT

←Older revision		Revision as of 09:49, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [https://pdbe.org/2kok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [https://www.ebi.ac.uk/pdbsum/2kok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [https://pdbe.org/2kok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [https://www.ebi.ac.uk/pdbsum/2kok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:46, 14 June 2023

OCA — Wed, 14 Jun 2023 08:46:24 GMT

←Older revision		Revision as of 08:46, 14 June 2023
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	==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==		==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==
-	<StructureSection load='2kok' size='340' side='right'caption='[[2kok~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kok' size='340' side='right'caption='[[2kok]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_abortus"_schmidt_in_schmidt_and_weis_1901 "bacterium~~ abortus~~" schmidt in schmidt and weis 1901~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacterium abortus" Schmidt in Schmidt and Weis 1901])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [https://pdbe.org/2kok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [https://www.ebi.ac.uk/pdbsum/2kok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [https://pdbe.org/2kok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [https://www.ebi.ac.uk/pdbsum/2kok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2YMA4_BRUA2 Q2YMA4_BRUA2]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ abortus ~~schmidt in schmidt and weis 1901~~]]	+	[[Category: Brucella abortus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buchko~~, G W~~]]	+	[[Category: Buchko GW]]
-	[[Category: Hewitt~~, S N~~]]	+	[[Category: Hewitt SN]]
-	[[Category: Napuli~~, A J]]~~	+	[[Category: Napuli AJ]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Van Voorhis WC]]
-	[[Category: Voorhis~~, W C.Van]]~~	+
-	~~[[Category: Arsenate reductase]]~~	+
-	~~[[Category: Brucellosis]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Zoonotic~~]]	+

OCA at 07:08, 1 December 2021

OCA — Wed, 01 Dec 2021 07:08:22 GMT

←Older revision		Revision as of 07:08, 1 December 2021
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	<StructureSection load='2kok' size='340' side='right'caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kok' size='340' side='right'caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_abortus"_schmidt_in_schmidt_and_weis_1901 "bacterium abortus" schmidt in schmidt and weis 1901]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_abortus"_schmidt_in_schmidt_and_weis_1901 "bacterium abortus" schmidt in schmidt and weis 1901]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacterium abortus" Schmidt in Schmidt and Weis 1901])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacterium abortus" Schmidt in Schmidt and Weis 1901])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [~~http~~://pdbe.org/2kok PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kok PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [https://pdbe.org/2kok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [https://www.ebi.ac.uk/pdbsum/2kok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:41, 26 February 2020

OCA — Wed, 26 Feb 2020 09:41:50 GMT

←Older revision		Revision as of 09:41, 26 February 2020
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	==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==		==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==
-	<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kok' size='340' side='right'caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_of_abortion~~"~~_bang_1897~~ "~~bacillus of abortion~~" ~~bang 1897~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_abortus"_schmidt_in_schmidt_and_weis_1901 "bacterium abortus" schmidt in schmidt and weis 1901]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "~~Bacillus of abortion~~" ~~Bang 1897~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacterium abortus" Schmidt in Schmidt and Weis 1901])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://pdbe.org/2kok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://pdbe.org/2kok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>
	</table>		</table>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Arsenate reductase\|Arsenate reductase]]	+	*[[Arsenate reductase 3D structures\|Arsenate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus of abortion bang 1897~~]]	+	[[Category: Bacterium abortus schmidt in schmidt and weis 1901]]
		+	[[Category: Large Structures]]
	[[Category: Buchko, G W]]		[[Category: Buchko, G W]]
	[[Category: Hewitt, S N]]		[[Category: Hewitt, S N]]

OCA at 08:24, 25 July 2018

OCA — Wed, 25 Jul 2018 08:24:28 GMT

←Older revision		Revision as of 08:24, 25 July 2018
Line 1:		Line 1:
		+
	==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==		==Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.==
	<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_of_abortion"_bang_1897 "bacillus of abortion" bang 1897]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_of_abortion"_bang_1897 "bacillus of abortion" bang 1897]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacillus of abortion" Bang 1897])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacillus of abortion" Bang 1897])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://pdbe.org/2kok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://pdbe.org/2kok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kok ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kok_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kok_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 2kok" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2kok" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arsenate reductase\|Arsenate reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	[[Category: Hewitt, S N]]		[[Category: Hewitt, S N]]
	[[Category: Napuli, A J]]		[[Category: Napuli, A J]]
		+	[[Category: Structural genomic]]
	[[Category: Voorhis, W C.Van]]		[[Category: Voorhis, W C.Van]]
	[[Category: Arsenate reductase]]		[[Category: Arsenate reductase]]
	[[Category: Brucellosis]]		[[Category: Brucellosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Structural genomic]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	[[Category: Zoonotic]]		[[Category: Zoonotic]]

OCA at 20:59, 9 February 2016

OCA — Tue, 09 Feb 2016 20:59:53 GMT

←Older revision		Revision as of 20:59, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kok ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:59, 11 September 2015

OCA — Fri, 11 Sep 2015 01:59:04 GMT

←Older revision		Revision as of 01:59, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Brucella_abortus Brucella abortus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_of_abortion"_bang_1897 "bacillus of abortion" bang 1897]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 ~~Brucella abortus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 "Bacillus of abortion" Bang 1897])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://pdbe.org/2kok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kok" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brucella abortus~~]]	+	[[Category: Bacillus of abortion bang 1897]]
	[[Category: Buchko, G W]]		[[Category: Buchko, G W]]
	[[Category: Hewitt, S N]]		[[Category: Hewitt, S N]]

OCA at 14:08, 19 January 2015

OCA — Mon, 19 Jan 2015 14:08:15 GMT

←Older revision		Revision as of 14:08, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 Brucella abortus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 Brucella abortus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Brucella abortus]]		[[Category: Brucella abortus]]
-	[[Category: Buchko, G W.]]	+	[[Category: Buchko, G W]]
-	[[Category: Hewitt, S N.]]	+	[[Category: Hewitt, S N]]
-	[[Category: Napuli, A J.]]	+	[[Category: Napuli, A J]]
-	[[Category: Voorhis, W C.Van.]]	+	[[Category: Voorhis, W C.Van]]
	[[Category: Arsenate reductase]]		[[Category: Arsenate reductase]]
	[[Category: Brucellosis]]		[[Category: Brucellosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
-	[[Category: Ssgcid]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Ssgcid]]
	[[Category: Zoonotic]]		[[Category: Zoonotic]]

OCA at 10:28, 3 October 2014

OCA — Fri, 03 Oct 2014 10:28:40 GMT

←Older revision		Revision as of 10:28, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 Brucella abortus])</td></tr>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 Brucella abortus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>
	<table>		<table>
Line 23:		Line 22:
	Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.,Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1129-36. Epub 2011 Aug 16. PMID:21904062<ref>PMID:21904062</ref>		Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.,Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1129-36. Epub 2011 Aug 16. PMID:21904062<ref>PMID:21904062</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:49, 1 May 2014

OCA — Thu, 01 May 2014 09:49:10 GMT

←Older revision		Revision as of 09:49, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kok' size='340' side='right' caption='[[2kok]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. <br>	+	<table><tr><td colspan='2'>[[2kok]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_abortus Brucella abortus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOK OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ArsC, BruAb1_0395 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235 Brucella abortus])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kok RCSB], [http://www.ebi.ac.uk/pdbsum/2kok PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 15:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Brucella melitensis is the etiological agent responsible for brucellosis. Present in the B. melitensis genome is a 116-residue protein related to arsenate reductases (Bm-YffB; BR0369). Arsenate reductases (ArsC) convert arsenate ion (H(2)AsO(4)(-)), a compound that is toxic to bacteria, to arsenite ion (AsO(2)(-)), a product that may be efficiently exported out of the cell. Consequently, Bm-YffB is a potential drug target because if arsenate reduction is the protein's major biological function then disabling the cell's ability to reduce arsenate would make these cells more sensitive to the deleterious effects of arsenate. Size-exclusion chromatography and NMR spectroscopy indicate that Bm-YffB is a monomer in solution. The solution structure of Bm-YffB (PDB entry 2kok) shows that the protein consists of two domains: a four-stranded mixed beta-sheet flanked by two alpha-helices on one side and an alpha-helical bundle. The alpha/beta domain is characteristic of the fold of thioredoxin-like proteins and the overall structure is generally similar to those of known arsenate reductases despite the marginal sequence similarity. Chemical shift perturbation studies with (15)N-labeled Bm-YffB show that the protein binds reduced glutathione at a site adjacent to a region similar to the HX(3)CX(3)R catalytic sequence motif that is important for arsenic detoxification activity in the classical arsenate-reductase family of proteins. The latter observation supports the hypothesis that the ArsC-YffB family of proteins may function as glutathione-dependent thiol reductases. However, comparison of the structure of Bm-YffB with the structures of proteins from the classical ArsC family suggest that the mechanism and possibly the function of Bm-YffB and other related proteins (ArsC-YffB) may differ from those of the ArsC family of proteins.		Brucella melitensis is the etiological agent responsible for brucellosis. Present in the B. melitensis genome is a 116-residue protein related to arsenate reductases (Bm-YffB; BR0369). Arsenate reductases (ArsC) convert arsenate ion (H(2)AsO(4)(-)), a compound that is toxic to bacteria, to arsenite ion (AsO(2)(-)), a product that may be efficiently exported out of the cell. Consequently, Bm-YffB is a potential drug target because if arsenate reduction is the protein's major biological function then disabling the cell's ability to reduce arsenate would make these cells more sensitive to the deleterious effects of arsenate. Size-exclusion chromatography and NMR spectroscopy indicate that Bm-YffB is a monomer in solution. The solution structure of Bm-YffB (PDB entry 2kok) shows that the protein consists of two domains: a four-stranded mixed beta-sheet flanked by two alpha-helices on one side and an alpha-helical bundle. The alpha/beta domain is characteristic of the fold of thioredoxin-like proteins and the overall structure is generally similar to those of known arsenate reductases despite the marginal sequence similarity. Chemical shift perturbation studies with (15)N-labeled Bm-YffB show that the protein binds reduced glutathione at a site adjacent to a region similar to the HX(3)CX(3)R catalytic sequence motif that is important for arsenic detoxification activity in the classical arsenate-reductase family of proteins. The latter observation supports the hypothesis that the ArsC-YffB family of proteins may function as glutathione-dependent thiol reductases. However, comparison of the structure of Bm-YffB with the structures of proteins from the classical ArsC family suggest that the mechanism and possibly the function of Bm-YffB and other related proteins (ArsC-YffB) may differ from those of the ArsC family of proteins.
Line 21:		Line 24:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>