2kqh - Revision history

OCA at 06:47, 1 May 2024

OCA — Wed, 01 May 2024 06:47:47 GMT

←Older revision		Revision as of 06:47, 1 May 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale.
-
-	A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869<ref>PMID:19705869</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2kqh" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:25, 8 November 2023

OCA — Wed, 08 Nov 2023 17:25:24 GMT

←Older revision		Revision as of 17:25, 8 November 2023
Line 1:		Line 1:

	==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==		==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==
-	<StructureSection load='2kqh' size='340' side='right'caption='[[2kqh~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2kqh' size='340' side='right'caption='[[2kqh]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow: auto; max-height~~: ~~3em;~~'>~~[[2kqg\|2kqg]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Balasubramanian, S]]	+	[[Category: Balasubramanian S]]
-	[[Category: Bugaut, A]]	+	[[Category: Bugaut A]]
-	[[Category: Hsu, S ~~T.D~~]]	+	[[Category: Hsu S-TD]]
-	[[Category: Neidle, S]]	+	[[Category: Neidle S]]
-	[[Category: Reszka~~, A P~~]]	+	[[Category: Reszka AP]]
-	[[Category: Varnai, P]]	+	[[Category: Varnai P]]
-	~~[[Category: C-kit2]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G-quadruplex]]~~	+
-	~~[[Category: Oncogene]]~~	+
-	~~[[Category: Promoter~~]]	+

OCA at 07:35, 2 February 2022

OCA — Wed, 02 Feb 2022 07:35:39 GMT

←Older revision		Revision as of 07:35, 2 February 2022
Line 3:		Line 3:
	<StructureSection load='2kqh' size='340' side='right'caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kqh' size='340' side='right'caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kqg\|2kqg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [~~http~~://pdbe.org/2kqh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:34, 29 April 2020

OCA — Wed, 29 Apr 2020 07:34:57 GMT

←Older revision		Revision as of 07:34, 29 April 2020
Line 1:		Line 1:

	==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==		==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==
-	<StructureSection load='2kqh' size='340' side='right' caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2kqh' size='340' side='right'caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://pdbe.org/2kqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://pdbe.org/2kqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Balasubramanian, S]]		[[Category: Balasubramanian, S]]
	[[Category: Bugaut, A]]		[[Category: Bugaut, A]]

OCA at 08:21, 25 July 2018

OCA — Wed, 25 Jul 2018 08:21:39 GMT

←Older revision		Revision as of 08:21, 25 July 2018
Line 1:		Line 1:
		+
	==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==		==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==
	<StructureSection load='2kqh' size='340' side='right' caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kqh' size='340' side='right' caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://pdbe.org/2kqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://pdbe.org/2kqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:56, 10 September 2015

OCA — Thu, 10 Sep 2015 01:56:24 GMT

←Older revision		Revision as of 01:56, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://pdbe.org/2kqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kqh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:56, 25 January 2015

OCA — Sun, 25 Jan 2015 09:56:35 GMT

←Older revision		Revision as of 09:56, 25 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Balasubramanian, S.]]	+	[[Category: Balasubramanian, S]]
-	[[Category: Bugaut, A.]]	+	[[Category: Bugaut, A]]
-	[[Category: Hsu, S T.D.]]	+	[[Category: Hsu, S T.D]]
-	[[Category: Neidle, S.]]	+	[[Category: Neidle, S]]
-	[[Category: Reszka, A P.]]	+	[[Category: Reszka, A P]]
-	[[Category: Varnai, P.]]	+	[[Category: Varnai, P]]
	[[Category: C-kit2]]		[[Category: C-kit2]]
	[[Category: Dna]]		[[Category: Dna]]

OCA at 09:23, 5 November 2014

OCA — Wed, 05 Nov 2014 09:23:59 GMT

←Older revision		Revision as of 09:23, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2kqh.~~png~~\|~~left~~\|~~200px~~]]	+	==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics==
		+	<StructureSection load='2kqh' size='340' side='right' caption='[[2kqh]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KQH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kqg\|2kqg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [http://www.ebi.ac.uk/pdbsum/2kqh PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale.

-	~~{{STRUCTURE_2kqh\| PDB=2kqh \| SCENE= }}~~	+	A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869<ref>PMID:19705869</ref>

-	~~===A G-rich sequence within the c-kit oncogene promoter forms~~ a ~~parallel G-quadruplex having asymmetric G-tetrad dynamics===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19705869}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2kqh]] is a 1 chain structure. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019705869<~~/~~ref~~><~~ref group="xtra">PMID:016784237</ref><references group="xtra"~~/>	+
	[[Category: Balasubramanian, S.]]		[[Category: Balasubramanian, S.]]
	[[Category: Bugaut, A.]]		[[Category: Bugaut, A.]]

OCA at 13:04, 30 January 2013

OCA — Wed, 30 Jan 2013 13:04:14 GMT

←Older revision		Revision as of 13:04, 30 January 2013
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	[[Image:2kqh.png\|left\|200px]]		[[Image:2kqh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kqh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kqh\| PDB=2kqh \| SCENE= }}		{{STRUCTURE_2kqh\| PDB=2kqh \| SCENE= }}

	===A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics===		===A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19705869}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19705869 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19705869}}		{{ABSTRACT_PUBMED_19705869}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19705869~~</ref><ref group="xtra">PMID:~~16784237~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019705869</ref><ref group="xtra">PMID:016784237</ref><references group="xtra"/>
	[[Category: Balasubramanian, S.]]		[[Category: Balasubramanian, S.]]
	[[Category: Bugaut, A.]]		[[Category: Bugaut, A.]]

OCA: Protected "2kqh" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 20:41:16 GMT

Protected "2kqh" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:41, 14 March 2011