2kz1 - Revision history

OCA at 07:34, 14 April 2021

OCA — Wed, 14 Apr 2021 07:34:04 GMT

←Older revision		Revision as of 07:34, 14 April 2021
Line 1:		Line 1:

	==Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY==		==Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY==
-	<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2kz1' size='340' side='right'caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNABR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNABR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [~~http~~://pdbe.org/2kz1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kz1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [https://pdbe.org/2kz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. [[~~http~~://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN]] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>	+	[[https://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. [[https://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN]] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Interferon\|Interferon]]	+	*[[Interferon 3D structures\|Interferon 3D structures]]
-	*[[Interferon receptor\|Interferon receptor]]	+	*[[Interferon receptor 3D structures\|Interferon receptor 3D structures]]
	*[[Multiple sclerosis\|Multiple sclerosis]]		*[[Multiple sclerosis\|Multiple sclerosis]]
	== References ==		== References ==
Line 39:		Line 39:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Interferons]]		[[Category: Interferons]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Akabayov, S R]]		[[Category: Akabayov, S R]]

OCA at 08:31, 25 July 2018

OCA — Wed, 25 Jul 2018 08:31:01 GMT

←Older revision		Revision as of 08:31, 25 July 2018
Line 1:		Line 1:
		+
	==Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY==		==Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY==
	<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNABR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNABR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://pdbe.org/2kz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://pdbe.org/2kz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kz1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:24, 10 September 2015

OCA — Thu, 10 Sep 2015 17:24:45 GMT

←Older revision		Revision as of 17:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), IFNABR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNABR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://pdbe.org/2kz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities.	+	[[http://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. [[http://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN]] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kz1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Interferons]]		[[Category: Interferons]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]

OCA at 03:34, 25 December 2014

OCA — Thu, 25 Dec 2014 03:34:46 GMT

←Older revision		Revision as of 03:34, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:45, 22 December 2014

OCA — Mon, 22 Dec 2014 06:45:46 GMT

←Older revision		Revision as of 06:45, 22 December 2014
Line 1:		Line 1:
-	[[~~Image~~:2kz1.~~png\|left~~\|200px]]	+	==Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY==
		+	<StructureSection load='2kz1' size='340' side='right' caption='[[2kz1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ1 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IFNABR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz1 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type I interferons (IFNs) make up a family of homologous helical cytokines initiating strong antiviral and antiproliferative activity. All type I IFNs bind to a common cell surface receptor consisting of two subunits, IFNAR1 and IFNAR2, associating upon binding of interferon. We studied intermolecular interactions between IFNAR2-EC and IFNalpha2 using asymmetric reverse-protonation of the different complex components and two-dimensional homonuclear NOESY. This new approach revealed with an excellent signal-to-noise ratio 24 new intermolecular NOEs between the two molecules despite the low concentration of the complex (0.25 mM) and its high molecular mass (44 kDa). Sequential and side chain assignment of IFNAR2-EC and IFNalpha2 in their binary complex helped assign the intermolecular NOEs to the corresponding protons. A docking model of the IFNAR2-EC-IFNalpha2 complex was calculated on the basis of the intermolecular interactions found in this study as well as four double mutant cycle constraints, previously observed NOEs between a single pair of residues and the NMR mapping of the binding sites on IFNAR2-EC and IFNalpha2. Our docking model doubles the buried surface area of the previous model and significantly increases the number of intermolecular hydrogen bonds, salt bridges, and van der Waals interactions. Furthermore, our model reveals the participation of several new regions in the binding site such as the N-terminus and A helix of IFNalpha2 and the C domain of IFNAR2-EC. As a result of these additions, the orientation of IFNAR2-EC relative to IFNalpha2 has changed by 30 degrees in comparison with a previously calculated model that was based on NMR mapping of the binding sites and double mutant cycle constraints. In addition, the new model strongly supports the recently proposed allosteric changes in IFNalpha2 upon binding of IFNAR1-EC to the binary IFNalpha2-IFNAR2-EC complex.

-	~~{{STRUCTURE_2kz1\| PDB=2kz1 \| SCENE= }}~~	+	Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY.,Nudelman I, Akabayov SR, Schnur E, Biron Z, Levy R, Xu Y, Yang D, Anglister J Biochemistry. 2010 Jun 29;49(25):5117-33. PMID:20496919<ref>PMID:20496919</ref>

-	~~===Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20496919}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2kz1]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1~~&~~id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule~~ of the ~~Month] feature on ''Interferons'' by David Goodsell is [http://dx~~.~~doi~~.~~org/10~~.~~2210~~/~~rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].~~	+

	==See Also==		==See Also==
	*[[Interferon\|Interferon]]		*[[Interferon\|Interferon]]
		+	*[[Interferon receptor\|Interferon receptor]]
	*[[Multiple sclerosis\|Multiple sclerosis]]		*[[Multiple sclerosis\|Multiple sclerosis]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020496919<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Interferons]]		[[Category: Interferons]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Akabayov, S R.]]	+	[[Category: Akabayov, S R]]
-	[[Category: Anglister, J.]]	+	[[Category: Anglister, J]]
-	[[Category: Biron, Z.]]	+	[[Category: Biron, Z]]
-	[[Category: Levy, R.]]	+	[[Category: Levy, R]]
-	[[Category: Nudelman, I.]]	+	[[Category: Nudelman, I]]
-	[[Category: Schnur, E.]]	+	[[Category: Schnur, E]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Yang, D.]]	+	[[Category: Yang, D]]
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]

OCA at 12:13, 20 October 2012

OCA — Sat, 20 Oct 2012 12:13:05 GMT

←Older revision		Revision as of 12:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2kz1]] is a 2 chain structure ~~of [[Multiple sclerosis]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].	+	[[2kz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].

	==See Also==		==See Also==

OCA at 10:59, 6 August 2012

OCA — Mon, 06 Aug 2012 10:59:56 GMT

←Older revision		Revision as of 10:59, 6 August 2012
Line 11:		Line 11:

	==See Also==		==See Also==
-	*[[~~Interferons~~\|~~Interferons~~]]	+	*[[Interferon\|Interferon]]
	*[[Multiple sclerosis\|Multiple sclerosis]]		*[[Multiple sclerosis\|Multiple sclerosis]]

OCA: Protected "2kz1" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 07:59:08 GMT

Protected "2kz1" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:59, 26 July 2012

OCA at 07:59, 26 July 2012

OCA — Thu, 26 Jul 2012 07:59:06 GMT

←Older revision		Revision as of 07:59, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2kz1.png\|left\|200px]]		[[Image:2kz1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kz1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kz1\| PDB=2kz1 \| SCENE= }}		{{STRUCTURE_2kz1\| PDB=2kz1 \| SCENE= }}

	===Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY===		===Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20496919}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20496919 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20496919}}		{{ABSTRACT_PUBMED_20496919}}

	==About this Structure==		==About this Structure==
-	~~2KZ1~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].	+	[[2kz1]] is a 2 chain structure of [[Multiple sclerosis]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. The August 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].
		+
		+	==See Also==
		+	*[[Interferons\|Interferons]]
		+	*[[Multiple sclerosis\|Multiple sclerosis]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20496919~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020496919</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Interferons]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Akabayov, S R.]]		[[Category: Akabayov, S R.]]
	[[Category: Anglister, J.]]		[[Category: Anglister, J.]]
Line 43:		Line 37:
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:08:46 2010''

OCA at 04:03, 7 July 2010

OCA — Wed, 07 Jul 2010 04:03:17 GMT

←Older revision		Revision as of 04:03, 7 July 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2kz1.~~jpg~~\|left\|200px]]	+	[[Image:2kz1.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY===		===Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20496919}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20496919 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20496919}}

	==About this Structure==		==About this Structure==
	2KZ1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].		2KZ1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ksx 2ksx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20496919</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Akabayov, S R.]]		[[Category: Akabayov, S R.]]
Line 32:		Line 41:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Interferon]]		[[Category: Interferon]]
-	[[Category: Pharmaceutical]]
-	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 23~~ 08:44:59 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:08:46 2010''