2l3o - Revision history

OCA at 08:16, 18 January 2023

OCA — Wed, 18 Jan 2023 08:16:04 GMT

←Older revision		Revision as of 08:16, 18 January 2023
Line 1:		Line 1:

	==Solution structure of murine interleukin 3==		==Solution structure of murine interleukin 3==
-	<StructureSection load='2l3o' size='340' side='right'caption='[[2l3o~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2l3o' size='340' side='right'caption='[[2l3o]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [https://pdbe.org/2l3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [https://www.ebi.ac.uk/pdbsum/2l3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3o ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [https://pdbe.org/2l3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [https://www.ebi.ac.uk/pdbsum/2l3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3o ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IL3_MOUSE IL3_MOUSE] Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:8378315, PubMed:10376805). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).[UniProtKB:P08700]<ref>PMID:10376805</ref> <ref>PMID:8378315</ref> <ref>PMID:9446636</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Murphy~~, J M~~]]	+	[[Category: Murphy JM]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Norton RS]]
-	[[Category: Yao, S]]	+	[[Category: Yao S]]
-	[[Category: Young~~, I G]]~~	+	[[Category: Young IG]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Murine interleukin-3~~]]	+

OCA at 07:35, 14 April 2021

OCA — Wed, 14 Apr 2021 07:35:51 GMT

←Older revision		Revision as of 07:35, 14 April 2021
Line 1:		Line 1:

	==Solution structure of murine interleukin 3==		==Solution structure of murine interleukin 3==
-	<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2l3o' size='340' side='right'caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [~~http~~://pdbe.org/2l3o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l3o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [https://pdbe.org/2l3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [https://www.ebi.ac.uk/pdbsum/2l3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Murphy, J M]]		[[Category: Murphy, J M]]

OCA at 07:51, 25 July 2018

OCA — Wed, 25 Jul 2018 07:51:26 GMT

←Older revision		Revision as of 07:51, 25 July 2018
Line 1:		Line 1:
		+
	==Solution structure of murine interleukin 3==		==Solution structure of murine interleukin 3==
	<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://pdbe.org/2l3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://pdbe.org/2l3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:47, 10 September 2015

OCA — Thu, 10 Sep 2015 10:47:29 GMT

←Older revision		Revision as of 10:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://pdbe.org/2l3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l3o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Murphy, J M]]		[[Category: Murphy, J M]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]

OCA at 14:53, 19 January 2015

OCA — Mon, 19 Jan 2015 14:53:58 GMT

←Older revision		Revision as of 14:53, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Murphy, J M.]]	+	[[Category: Murphy, J M]]
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
-	[[Category: Yao, S.]]	+	[[Category: Yao, S]]
-	[[Category: Young, I G.]]	+	[[Category: Young, I G]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Murine interleukin-3]]		[[Category: Murine interleukin-3]]

OCA at 02:47, 29 September 2014

OCA — Mon, 29 Sep 2014 02:47:53 GMT

←Older revision		Revision as of 02:47, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2l3o.~~png~~\|~~left\|200px~~]]	+	==Solution structure of murine interleukin 3==
		+	<StructureSection load='2l3o' size='340' side='right' caption='[[2l3o]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il3, mCG_13767, mIL-3, RP23-309E16.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3o RCSB], [http://www.ebi.ac.uk/pdbsum/2l3o PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin-3 (IL-3), a cytokine produced primarily by activated T-cells during immune responses, is a crucial regulator of allergic inflammation. The three-dimensional structure of murine IL-3 (mIL-3) has remained elusive owing to its poor solubility and strong tendency toward aggregation under solution conditions typically used for structural studies. Here we describe the solution properties and structure of mIL-3 determined by NMR using an engineered construct of mIL-3 (mIL-3(33-156)). mIL-3 adopts a four-helical bundle fold, typical of proteins belonging to the short-chain cytokine family, and features a core of highly conserved hydrophobic residues. While significant line broadening and peak disappearance were observed in NMR spectra at higher temperatures, there was no evidence for temperature-dependent changes of the oligomeric state of mIL-3(33-156). Further analysis of the temperature dependence of amide (1)H chemical shifts and backbone (15)N relaxation parameters, including (15)N relaxation dispersion, revealed the presence of significant conformational exchange and local conformational heterogeneity. Residues recently shown by mutagenesis to play key roles in beta(IL-3) receptor recognition and activation, which are located within the alpha(A) and alpha(C) helices and aligned on one face of the mIL-3(33-156) structure, are relatively rigid. In contrast, pronounced conformational heterogeneity was observed for a cluster of residues located on the opposite side of mIL-3, which corresponds spatially to sites in the related cytokines human IL-3, IL-5, and GM-CSF that are known to mediate interactions with their respective alpha-receptor subunits. Such conformational heterogeneity may facilitate the interaction of mIL-3 with each of two naturally occurring mIL-3Ralpha isoforms, leading to structurally distinct high-affinity complexes.

-	~~{{STRUCTURE_2l3o\| PDB=2l3o \| SCENE= }}~~	+	Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.,Yao S, Young IG, Norton RS, Murphy JM Biochemistry. 2011 Apr 5;50(13):2464-77. Epub 2011 Mar 2. PMID:21329364<ref>PMID:21329364</ref>

-	~~===Solution structure~~ of ~~murine interleukin 3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21329364}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2l3o]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].~~	+

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021329364<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Murphy, J M.]]		[[Category: Murphy, J M.]]

OCA at 09:54, 20 October 2012

OCA — Sat, 20 Oct 2012 09:54:10 GMT

←Older revision		Revision as of 09:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2l3o]] is a 1 chain structure ~~of [[Interleukin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].	+	[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].

	==See Also==		==See Also==

OCA at 00:19, 26 July 2012

OCA — Thu, 26 Jul 2012 00:19:07 GMT

←Older revision		Revision as of 00:19, 26 July 2012
Line 1:		Line 1:
-	[[Image:2l3o.~~jpg~~\|left\|200px]]	+	[[Image:2l3o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2l3o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2l3o\| PDB=2l3o \| SCENE= }}		{{STRUCTURE_2l3o\| PDB=2l3o \| SCENE= }}

	===Solution structure of murine interleukin 3===		===Solution structure of murine interleukin 3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21329364}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21329364 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21329364}}		{{ABSTRACT_PUBMED_21329364}}

	==About this Structure==		==About this Structure==
-	[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].	+	[[2l3o]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]

	==Reference==		==Reference==

OCA: Protected "2l3o" [edit=sysop:move=sysop]

OCA — Wed, 10 Aug 2011 06:01:06 GMT

Protected "2l3o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:01, 10 August 2011

OCA at 06:01, 10 August 2011

OCA — Wed, 10 Aug 2011 06:01:03 GMT

←Older revision		Revision as of 06:01, 10 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2l3o.jpg\|left\|200px]]

-	The ~~entry 2l3o~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2l3o", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2l3o\| PDB=2l3o \| SCENE= }}

-	~~Authors: Yao, S., Young, I.G., Norton, R.S., Murphy, J.M.~~	+	===Solution structure of murine interleukin 3===

-	Description: Solution structure of murine interleukin 3

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Oct 20 06~~:13:~~47 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21329364}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21329364 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21329364}}
		+
		+	==About this Structure==
		+	[[2l3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3O OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021329364</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Murphy, J M.]]
		+	[[Category: Norton, R S.]]
		+	[[Category: Yao, S.]]
		+	[[Category: Young, I G.]]
		+	[[Category: Cytokine]]
		+	[[Category: Murine interleukin-3]]