2l66 - Revision history

OCA at 06:53, 1 May 2024

OCA — Wed, 01 May 2024 06:53:38 GMT

←Older revision		Revision as of 06:53, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_98/2 Saccharolobus solfataricus 98/2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_98/2 Saccharolobus solfataricus 98/2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/D0KRA5_SACS9 D0KRA5_SACS9]		[https://www.uniprot.org/uniprot/D0KRA5_SACS9 D0KRA5_SACS9]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.
-
-	The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2l66" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:22, 18 January 2023

OCA — Wed, 18 Jan 2023 08:22:52 GMT

←Older revision		Revision as of 08:22, 18 January 2023
Line 1:		Line 1:

	==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==		==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
-	<StructureSection load='2l66' size='340' side='right'caption='[[2l66~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='2l66' size='340' side='right'caption='[[2l66]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Suls9 Suls9~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_98/2 Saccharolobus solfataricus 98/2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0KRA5_SACS9 D0KRA5_SACS9]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Suls9~~]]	+	[[Category: Saccharolobus solfataricus 98/2]]
-	[[Category: Hsu, C H]]	+	[[Category: Hsu C-H]]
-	[[Category: Wang~~, A H.~~J]]	+	[[Category: Wang AH-J]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Transcription regulator~~]]	+

OCA at 07:37, 14 April 2021

OCA — Wed, 14 Apr 2021 07:37:10 GMT

←Older revision		Revision as of 07:37, 14 April 2021
Line 1:		Line 1:

	==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==		==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
-	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='2l66' size='340' side='right'caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Suls9 Suls9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Suls9 Suls9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [~~http~~://pdbe.org/2l66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Suls9]]		[[Category: Suls9]]
	[[Category: Hsu, C H]]		[[Category: Hsu, C H]]

OCA at 19:48, 1 August 2018

OCA — Wed, 01 Aug 2018 19:48:25 GMT

←Older revision		Revision as of 19:48, 1 August 2018
Line 1:		Line 1:
		+
	==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==		==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Suls9 Suls9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Suls9 Suls9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://pdbe.org/2l66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://pdbe.org/2l66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:44, 10 September 2015

OCA — Thu, 10 Sep 2015 22:44:15 GMT

←Older revision		Revision as of 22:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Suls9 Suls9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~2287 Sulfolobus solfataricus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://pdbe.org/2l66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l66" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Suls9]]
	[[Category: Hsu, C H]]		[[Category: Hsu, C H]]
	[[Category: Wang, A H.J]]		[[Category: Wang, A H.J]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 05:37, 22 December 2014

OCA — Mon, 22 Dec 2014 05:37:46 GMT

←Older revision		Revision as of 05:37, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>	+	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>		The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
-	[[Category: Hsu, C H.]]	+	[[Category: Hsu, C H]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 09:42, 1 May 2014

OCA — Thu, 01 May 2014 09:42:08 GMT

←Older revision		Revision as of 09:42, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>	+	<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ssol_1031 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.		Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.
Line 11:		Line 14:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 30 April 2014

OCA — Wed, 30 Apr 2014 10:03:13 GMT

←Older revision		Revision as of 10:03, 30 April 2014
Line 4:		Line 4:
	[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>		[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [http://www.ebi.ac.uk/pdbsum/2l66 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.		Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.

OCA at 08:25, 30 April 2014

OCA — Wed, 30 Apr 2014 08:25:47 GMT

←Older revision		Revision as of 08:25, 30 April 2014
Line 1:		Line 1:
-	[[~~Image:~~2l66~~.jpg~~\|~~left\|200px~~]]	+	==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
		+	<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.

-	<!--	+	The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2l66"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2l66\| PDB=2l66 \| SCENE= }}~~	+

-	~~===The DNA-recognition fold of Sso7c4 suggests~~ a ~~new member~~ of ~~SpoVT-AbrB superfamily from archaea.===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-		+	<references/>
-	~~<!--~~	+	__TOC__
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21546550}}, adds~~ the ~~Publication Abstract to the page~~	+	</StructureSection>
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21546550 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21546550}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~[[2l66]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA].~~	+
-		+
-	~~==Reference==~~	+
-	<~~ref group="xtra">PMID:021546550</ref><references group="xtra"~~/>	+
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Hsu, C H.]]		[[Category: Hsu, C H.]]

OCA at 06:11, 7 September 2011

OCA — Wed, 07 Sep 2011 06:11:39 GMT

←Older revision		Revision as of 06:11, 7 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2l66.jpg\|left\|200px]]

-	The ~~entry 2l66~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2l66", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2l66\| PDB=2l66 \| SCENE= }}

-	~~Authors: Hsu, C., Wang, A.H.~~-J.	+	===The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.===

-	~~Description: The DNA~~-~~recognition fold of Sso7c4 suggests an ancestral role in~~ the ~~evolution of~~ the ~~beta~~-~~barrel~~ protein ~~family~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21546550}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21546550 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21546550}}
		+
		+	==About this Structure==
		+	[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021546550</ref><references group="xtra"/>
		+	[[Category: Sulfolobus solfataricus]]
		+	[[Category: Hsu, C H.]]
		+	[[Category: Wang, A H.J.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Transcription regulator]]