2l89 - Revision history

OCA at 05:39, 15 May 2024

OCA — Wed, 15 May 2024 05:39:48 GMT

←Older revision		Revision as of 05:39, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [https://pdbe.org/2l89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [https://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [https://pdbe.org/2l89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [https://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:52, 14 June 2023

OCA — Wed, 14 Jun 2023 08:52:43 GMT

←Older revision		Revision as of 08:52, 14 June 2023
Line 1:		Line 1:

	==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==		==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==
-	<StructureSection load='2l89' size='340' side='right'caption='[[2l89~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2l89' size='340' side='right'caption='[[2l89]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [https://pdbe.org/2l89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [https://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [https://pdbe.org/2l89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [https://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDP1_SCHPO PDP1_SCHPO]] Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.<ref>PMID:19250904</ref>	+	[https://www.uniprot.org/uniprot/PDP1_SCHPO PDP1_SCHPO] Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.<ref>PMID:19250904</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Qiu, Y~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Zhang, J~~]]	+	[[Category: Qiu Y]]
-	[[Category: Zhang~~, W~~]]	+	[[Category: Zhang J]]
-	[[Category: ~~Histone binding]]~~	+	[[Category: Zhang W]]
-	~~[[Category: Protein binding~~]]	+

OCA at 07:49, 9 February 2022

OCA — Wed, 09 Feb 2022 07:49:20 GMT

←Older revision		Revision as of 07:49, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2l89' size='340' side='right'caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l89' size='340' side='right'caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [~~http~~://pdbe.org/2l89 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [https://pdbe.org/2l89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [https://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDP1_SCHPO PDP1_SCHPO]] Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.<ref>PMID:19250904</ref>	+	[[https://www.uniprot.org/uniprot/PDP1_SCHPO PDP1_SCHPO]] Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.<ref>PMID:19250904</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:00, 6 May 2020

OCA — Wed, 06 May 2020 07:00:28 GMT

←Older revision		Revision as of 07:00, 6 May 2020
Line 1:		Line 1:

	==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==		==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==
-	<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2l89' size='340' side='right'caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://pdbe.org/2l89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://pdbe.org/2l89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Qiu, Y]]		[[Category: Qiu, Y]]
	[[Category: Zhang, J]]		[[Category: Zhang, J]]

OCA at 19:28, 1 August 2018

OCA — Wed, 01 Aug 2018 19:28:27 GMT

←Older revision		Revision as of 19:28, 1 August 2018
Line 1:		Line 1:
		+
	==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==		==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==
	<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://pdbe.org/2l89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://pdbe.org/2l89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:53, 10 September 2015

OCA — Thu, 10 Sep 2015 10:53:07 GMT

←Older revision		Revision as of 10:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://pdbe.org/2l89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l89" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Qiu, Y]]		[[Category: Qiu, Y]]
	[[Category: Zhang, J]]		[[Category: Zhang, J]]

OCA at 22:51, 24 December 2014

OCA — Wed, 24 Dec 2014 22:51:17 GMT

←Older revision		Revision as of 22:51, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDP1_SCHPO PDP1_SCHPO]] Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.<ref>PMID:19250904</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Qiu, Y.]]	+	[[Category: Qiu, Y]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
-	[[Category: Zhang, W.]]	+	[[Category: Zhang, W]]
	[[Category: Histone binding]]		[[Category: Histone binding]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 11:25, 20 October 2014

OCA — Mon, 20 Oct 2014 11:25:51 GMT

←Older revision		Revision as of 11:25, 20 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2l89.~~png\|left\|200px~~]]	+	==Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA==
		+	<StructureSection load='2l89' size='340' side='right' caption='[[2l89]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L89 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l89 RCSB], [http://www.ebi.ac.uk/pdbsum/2l89 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methylation of H4K20 plays an important role in the regulation of diverse cellular processes. In fission yeast, all the three states of H4K20 methylation are catalyzed by Set9. Pdp1 is a PWWP domain-containing protein, which associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. The structure of Pdp1 PWWP domain, which is the first identified PWWP domain that binds to methyl-lysine at H4K20 site, was determined by solution NMR in the present study. Pdp1 PWWP domain adopts a classical PWWP fold, with a 5-strand antiparallel beta-barrel followed by three alpha-helices. However, it differs significantly from other PWWP domains in some structural aspects that account in part for its molecular recognition. Moreover, we revealed a unique binding pattern of the PWWP domain in that the PWWP domain of Pdp1 bound not only to H4K20me3 but also to dsDNA via an aromatic cage and a positively charged area respectively. Electrophoretic Mobility Shift Assay (EMSA) illustrated the ability of Pdp1 PWWP domain to bind the nucleosome core particle and further mutagenesis experiments indicated the crucial role of this binding activity in histone H4K20 di- and tri- methylation in yeast cells. Our study may shed light on a novel mechanism of histone methylation regulation by the PWWP domain.

-	~~{{STRUCTURE_2l89\| PDB=2l89 \| SCENE= }}~~	+	Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.,Qiu Y, Zhang W, Zhao C, Wang Y, Wang W, Zhang J, Zhang Z, Li G, Shi Y, Tu X, Wu J Biochem J. 2011 Dec 13. PMID:22150589<ref>PMID:22150589</ref>

-	~~===Solution structure~~ of ~~Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22150589}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2l89]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA].~~	+	</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Qiu, Y.]]		[[Category: Qiu, Y.]]

OCA at 10:58, 7 January 2013

OCA — Mon, 07 Jan 2013 10:58:50 GMT

←Older revision		Revision as of 10:58, 7 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2l89.png\|left\|200px]]

-	~~The entry~~ 2l89 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2l89\| PDB=2l89 \| SCENE= }}

-	~~Authors: Qiu, Y., Zhang, J., Zhang, W.~~	+	===Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA===

-	~~Description~~: ~~A protein~~ from ~~yeast~~	+	{{ABSTRACT_PUBMED_22150589}}
		+
		+	==About this Structure==
		+	[[2l89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L89 OCA].
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Qiu, Y.]]
		+	[[Category: Zhang, J.]]
		+	[[Category: Zhang, W.]]
		+	[[Category: Histone binding]]
		+	[[Category: Protein binding]]

OCA at 05:59, 2 February 2011

OCA — Wed, 02 Feb 2011 05:59:25 GMT

←Older revision		Revision as of 05:59, 2 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2l89 is ON HOLD	+	The entry 2l89 is ON HOLD until Paper Publication

	Authors: Qiu, Y., Zhang, J., Zhang, W.		Authors: Qiu, Y., Zhang, J., Zhang, W.

	Description: A protein from yeast		Description: A protein from yeast