2l8j - Revision history

OCA at 05:39, 15 May 2024

OCA — Wed, 15 May 2024 05:39:56 GMT

←Older revision		Revision as of 05:39, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [https://pdbe.org/2l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [https://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [https://pdbe.org/2l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [https://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:26, 18 January 2023

OCA — Wed, 18 Jan 2023 08:26:24 GMT

←Older revision		Revision as of 08:26, 18 January 2023
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	==GABARAPL-1 NBR1-LIR complex structure==		==GABARAPL-1 NBR1-LIR complex structure==
-	<StructureSection load='2l8j' size='340' side='right'caption='[[2l8j~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2l8j' size='340' side='right'caption='[[2l8j]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [https://pdbe.org/2l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [https://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [https://pdbe.org/2l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [https://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> ~~[[https://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>~~	+	[https://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dikic, I]]	+	[[Category: Dikic I]]
-	[[Category: Doetsch, V]]	+	[[Category: Doetsch V]]
-	[[Category: Guentert, P]]	+	[[Category: Guentert P]]
-	[[Category: Loehr, F]]	+	[[Category: Loehr F]]
-	[[Category: Rogov~~, V V~~]]	+	[[Category: Rogov VV]]
-	[[Category: Rogova~~, N Y~~]]	+	[[Category: Rogova NY]]
-	[[Category: Rozenknop, A]]	+	[[Category: Rozenknop A]]
-	~~[[Category: Lc3 protein]]~~	+
-	~~[[Category: Selective autophagy]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signaling protein-protein binding complex~~]]	+

OCA at 07:38, 14 April 2021

OCA — Wed, 14 Apr 2021 07:38:17 GMT

←Older revision		Revision as of 07:38, 14 April 2021
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	==GABARAPL-1 NBR1-LIR complex structure==		==GABARAPL-1 NBR1-LIR complex structure==
-	<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2l8j' size='340' side='right'caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [~~http~~://pdbe.org/2l8j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [https://pdbe.org/2l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [https://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[~~http~~://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>	+	[[https://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[https://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[GABA~~(A)~~ receptor-associated protein\|GABA~~(A)~~ receptor-associated protein]]	+	*[[GABA receptor-associated protein 3D structures\|GABA receptor-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dikic, I]]		[[Category: Dikic, I]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]

OCA at 19:27, 1 August 2018

OCA — Wed, 01 Aug 2018 19:27:11 GMT

←Older revision		Revision as of 19:27, 1 August 2018
Line 1:		Line 1:
		+
	==GABARAPL-1 NBR1-LIR complex structure==		==GABARAPL-1 NBR1-LIR complex structure==
	<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://pdbe.org/2l8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://pdbe.org/2l8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2l8j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2l8j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GABA(A) receptor-associated protein\|GABA(A) receptor-associated protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:37, 11 September 2015

OCA — Fri, 11 Sep 2015 01:37:03 GMT

←Older revision		Revision as of 01:37, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://pdbe.org/2l8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l8j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dikic, I]]		[[Category: Dikic, I]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]

OCA at 09:14, 25 December 2014

OCA — Thu, 25 Dec 2014 09:14:12 GMT

←Older revision		Revision as of 09:14, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[http://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:45, 18 December 2014

OCA — Thu, 18 Dec 2014 11:45:36 GMT

←Older revision		Revision as of 11:45, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2l8j~~\| ~~PDB~~=2l8j \| ~~SCENE~~= }}	+	==GABARAPL-1 NBR1-LIR complex structure==
-	===GABARAPL-1 NBR1-LIR complex ~~structure===~~	+	<StructureSection load='2l8j' size='340' side='right' caption='[[2l8j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_21620860}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8J FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8j RCSB], [http://www.ebi.ac.uk/pdbsum/2l8j PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes. Recognition of autophagy receptors by autophagy effectors takes place through an LC3 interaction region (LIR). The canonical LIR motif consists of a WXXL sequence, N-terminally preceded by negatively charged residues. The LIR motif of NBR1 presents differences to this classical LIR motif with a tyrosine residue and an isoleucine residue substituting the tryptophan residue and the leucine residue, respectively. We have determined the structure of the GABARAPL-1/NBR1-LIR complex and studied the influence of the different residues belonging to the LIR motif for the interaction with several mammalian autophagy modifiers (LC3B and GABARAPL-1). Our results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity. Substitution by other aromatic amino acids or increasing the number of negatively charged residues at the N-terminus of the LIR motif, however, has little effect on the binding affinity due to enthalpy-entropy compensation. This indicates that different LIRs can interact with autophagy modifiers with unique binding properties.

-	~~==Function==~~	+	Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1.,Rozenknop A, Rogov VV, Rogova NY, Lohr F, Guntert P, Dikic I, Dotsch V J Mol Biol. 2011 Jul 15;410(3):477-87. Epub 2011 May 18. PMID:21620860<ref>PMID:21620860</ref>
-	~~[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression~~ of ~~kappa~~-~~type opioid receptor through facilitating anterograde intracellular trafficking of~~ the ~~receptor. Involved in formation~~ of ~~autophagosomal vacuoles~~.~~<ref>PMID~~:~~16431922</ref> <ref>~~PMID:~~20404487</ref> [[http://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.~~<ref>PMID:~~19250911~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2l8j]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021620860</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dikic, I.]]	+	[[Category: Dikic, I]]
-	[[Category: Doetsch, V.]]	+	[[Category: Doetsch, V]]
-	[[Category: Guentert, P.]]	+	[[Category: Guentert, P]]
-	[[Category: Loehr, F.]]	+	[[Category: Loehr, F]]
-	[[Category: Rogov, V V.]]	+	[[Category: Rogov, V V]]
-	[[Category: Rogova, N Y.]]	+	[[Category: Rogova, N Y]]
-	[[Category: Rozenknop, A.]]	+	[[Category: Rozenknop, A]]
	[[Category: Lc3 protein]]		[[Category: Lc3 protein]]
	[[Category: Selective autophagy]]		[[Category: Selective autophagy]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Signaling protein-protein binding complex]]		[[Category: Signaling protein-protein binding complex]]

OCA at 08:18, 8 May 2013

OCA — Wed, 08 May 2013 08:18:25 GMT

←Older revision		Revision as of 08:18, 8 May 2013
Line 1:		Line 1:
-	[[Image:2l8j.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2l8j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2l8j\| PDB=2l8j \| SCENE= }}		{{STRUCTURE_2l8j\| PDB=2l8j \| SCENE= }}
-
	===GABARAPL-1 NBR1-LIR complex structure===		===GABARAPL-1 NBR1-LIR complex structure===
		+	{{ABSTRACT_PUBMED_21620860}}

-		+	==Function==
-	<!--	+	[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[http://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN]] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21620860}}, adds the Publication Abstract to~~ the ~~page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21620860 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21620860}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021620860</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021620860</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dikic, I.]]		[[Category: Dikic, I.]]

OCA at 18:07, 6 July 2011

OCA — Wed, 06 Jul 2011 18:07:28 GMT

←Older revision		Revision as of 18:07, 6 July 2011
Line 1:		Line 1:
-	[[Image:2l8j.~~jpg~~\|left\|200px]]	+	[[Image:2l8j.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===GABARAPL-1 NBR1-LIR complex structure===		===GABARAPL-1 NBR1-LIR complex structure===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21620860}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21620860 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21620860}}

	==About this Structure==		==About this Structure==
	[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA].		[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021620860</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dikic, I.]]		[[Category: Dikic, I.]]
Line 22:		Line 31:
	[[Category: Rogova, N Y.]]		[[Category: Rogova, N Y.]]
	[[Category: Rozenknop, A.]]		[[Category: Rozenknop, A.]]
		+	[[Category: Lc3 protein]]
		+	[[Category: Selective autophagy]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signaling protein-protein binding complex]]

OCA at 04:46, 12 May 2011

OCA — Thu, 12 May 2011 04:46:20 GMT

←Older revision		Revision as of 04:46, 12 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2l8j.jpg\|left\|200px]]

-	The ~~entry 2l8j~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2l8j", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2l8j\| PDB=2l8j \| SCENE= }}

-	~~Authors: Rogov, V.V., Rozenknop, A., Rogova, N.Y., Loehr, F., Guentert, P., Dikic, I., Doetsch, V.~~	+	===GABARAPL-1 NBR1-LIR complex structure===

-	~~Description~~: ~~GABARAPL~~-~~1 NBR1-LIR complex structure~~	+
		+	==About this Structure==
		+	[[2l8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8J OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Dikic, I.]]
		+	[[Category: Doetsch, V.]]
		+	[[Category: Guentert, P.]]
		+	[[Category: Loehr, F.]]
		+	[[Category: Rogov, V V.]]
		+	[[Category: Rogova, N Y.]]
		+	[[Category: Rozenknop, A.]]