2l9s - Revision history

OCA at 05:40, 15 May 2024

OCA — Wed, 15 May 2024 05:40:36 GMT

←Older revision		Revision as of 05:40, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [https://pdbe.org/2l9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [https://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [https://pdbe.org/2l9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [https://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:27, 18 January 2023

OCA — Wed, 18 Jan 2023 08:27:35 GMT

←Older revision		Revision as of 08:27, 18 January 2023
Line 1:		Line 1:

	==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==		==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==
-	<StructureSection load='2l9s' size='340' side='right'caption='[[2l9s~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2l9s' size='340' side='right'caption='[[2l9s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9S FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s5q\|1s5q]], [[1s5r\|1s5r]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [https://pdbe.org/2l9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [https://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [https://pdbe.org/2l9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [https://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PHF12_HUMAN PHF12_HUMAN]] Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.<ref>PMID:11390640</ref> [[https://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>	+	[https://www.uniprot.org/uniprot/PHF12_HUMAN PHF12_HUMAN] Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.<ref>PMID:11390640</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Kumar, G Senthil~~]]	+	[[Category: Radhakrishnan I]]
-	[[Category: ~~Radhakrishnan, I~~]]	+	[[Category: Senthil Kumar G]]
-	[[Category: Xie, T]]	+	[[Category: Xie T]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Amphipathic helix motif]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:38, 14 April 2021

OCA — Wed, 14 Apr 2021 07:38:50 GMT

←Older revision		Revision as of 07:38, 14 April 2021
Line 1:		Line 1:

	==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==		==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==
-	<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2l9s' size='340' side='right'caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L9S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9S FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s5q\|1s5q]], [[1s5r\|1s5r]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [~~http~~://pdbe.org/2l9s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [https://pdbe.org/2l9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [https://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PHF12_HUMAN PHF12_HUMAN]] Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.<ref>PMID:11390640</ref> [[~~http~~://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>	+	[[https://www.uniprot.org/uniprot/PHF12_HUMAN PHF12_HUMAN]] Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.<ref>PMID:11390640</ref> [[https://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Kumar, G Senthil]]		[[Category: Kumar, G Senthil]]

OCA at 20:10, 1 August 2018

OCA — Wed, 01 Aug 2018 20:10:37 GMT

←Older revision		Revision as of 20:10, 1 August 2018
Line 1:		Line 1:
		+
	==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==		==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==
	<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://pdbe.org/2l9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://pdbe.org/2l9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:00, 10 September 2015

OCA — Thu, 10 Sep 2015 03:00:53 GMT

←Older revision		Revision as of 03:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Kiaa4126, Sin3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Kiaa4126, Sin3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://pdbe.org/2l9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l9s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Kumar, G Senthil]]		[[Category: Kumar, G Senthil]]
	[[Category: Radhakrishnan, I]]		[[Category: Radhakrishnan, I]]

OCA at 16:28, 24 December 2014

OCA — Wed, 24 Dec 2014 16:28:11 GMT

←Older revision		Revision as of 16:28, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHF12_HUMAN PHF12_HUMAN]] Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.<ref>PMID:11390640</ref> [[http://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:17, 17 December 2014

OCA — Wed, 17 Dec 2014 14:17:11 GMT

←Older revision		Revision as of 14:17, 17 December 2014
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-	~~{{STRUCTURE_2l9s\| PDB=2l9s \| SCENE= }}~~	+	==Solution structure of Pf1 SID1-mSin3A PAH2 Complex==
-	===Solution structure of Pf1 SID1-mSin3A PAH2 Complex===	+	<StructureSection load='2l9s' size='340' side='right' caption='[[2l9s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_21440557}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2l9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9S FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s5q\|1s5q]], [[1s5r\|1s5r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1523, Pf1, PHF12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Kiaa4126, Sin3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9s RCSB], [http://www.ebi.ac.uk/pdbsum/2l9s PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histone deacetylation constitutes an important mechanism for silencing genes. The histone-deacetylase-associated mammalian Rpd3S/Sin3S corepressor complex plays key roles in repressing aberrant gene transcription from cryptic transcription initiation sites and in mitigating RNA polymerase II progression in intragenic regions of actively transcribed genes. The Sin3 corepressor functions as a molecular adaptor linking histone deacetylases on the one hand, with the chromatin targeting subunits Pf1 and MRG15 on the other. Pf1 also functions as an adaptor by interacting with MRG15 and engaging in multivalent interactions with Sin3 targeting among other domains the two N-terminal paired amphipathic helix (PAH) domains that serve as sites of interaction with sequence-specific DNA-binding transcription factors. Here, we structurally and functionally evaluate the interaction between the PAH2 domain of mSin3A and the Sin3 interaction domain 1 (SID1) motif of Pf1 and find the structural aspects to be reminiscent of the interaction between the Mad1/Mxd1 transcription factor and Sin3. Pf1 residues within a highly conserved sequence motif immediately C-terminal to SID1 appear not to be important for the interaction with Sin3 PAH2. Unexpectedly, the MRG15 subunit competes, rather than collaborates, with Sin3 for the Pf1 segment encompassing the two conserved motifs, implying competition between two subunits for another subunit of the same chromatin-modifying complex.

-	~~==About this~~ Structure==	+	Solution Structure of the mSin3A PAH2-Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S Complex.,Kumar GS, Xie T, Zhang Y, Radhakrishnan I J Mol Biol. 2011 May 20;408(5):987-1000. Epub 2011 Apr 1. PMID:21440557<ref>PMID:21440557</ref>
-	~~[[2l9s]] is a 2 chain structure with sequence from [http~~://en.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:021440557<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Kumar, G Senthil.]]	+	[[Category: Kumar, G Senthil]]
-	[[Category: Radhakrishnan, I.]]	+	[[Category: Radhakrishnan, I]]
-	[[Category: Xie, T.]]	+	[[Category: Xie, T]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Amphipathic helix motif]]		[[Category: Amphipathic helix motif]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 11:11, 13 March 2013

OCA — Wed, 13 Mar 2013 11:11:02 GMT

←Older revision		Revision as of 11:11, 13 March 2013
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-	[[Image:2l9s.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_2l9s\| PDB=2l9s \| SCENE= }}		{{STRUCTURE_2l9s\| PDB=2l9s \| SCENE= }}
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	===Solution structure of Pf1 SID1-mSin3A PAH2 Complex===		===Solution structure of Pf1 SID1-mSin3A PAH2 Complex===
-
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-	<!--
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	[[Category: Xie, T.]]		[[Category: Xie, T.]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
		+	[[Category: Amphipathic helix motif]]
		+	[[Category: Protein-peptide complex]]
		+	[[Category: Transcription]]

OCA at 04:44, 12 May 2011

OCA — Thu, 12 May 2011 04:44:36 GMT

←Older revision		Revision as of 04:44, 12 May 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2l9s.jpg\|left\|200px]]

-	The ~~entry 2l9s~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2l9s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2l9s\| PDB=2l9s \| SCENE= }}

-	~~Authors: Senthil Kumar, G., Xie, T., Zhang, Y., Radhakrishnan, I.~~	+	===Solution structure of Pf1 SID1-mSin3A PAH2 Complex===

-	~~Description~~: ~~Solution~~ structure ~~of Pf1 SID1~~-~~mSin3A PAH2 Complex~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21440557}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21440557 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21440557}}
		+
		+	==About this Structure==
		+	[[2l9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021440557</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Kumar, G Senthil.]]
		+	[[Category: Radhakrishnan, I.]]
		+	[[Category: Xie, T.]]
		+	[[Category: Zhang, Y.]]

OCA at 07:51, 16 March 2011

OCA — Wed, 16 Mar 2011 07:51:13 GMT

←Older revision		Revision as of 07:51, 16 March 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2l9s is ON HOLD	+	The entry 2l9s is ON HOLD until Paper Publication

	Authors: Senthil Kumar, G., Xie, T., Zhang, Y., Radhakrishnan, I.		Authors: Senthil Kumar, G., Xie, T., Zhang, Y., Radhakrishnan, I.

	Description: Solution structure of Pf1 SID1-mSin3A PAH2 Complex		Description: Solution structure of Pf1 SID1-mSin3A PAH2 Complex