2lby - Revision history

OCA at 05:41, 15 May 2024

OCA — Wed, 15 May 2024 05:41:15 GMT

←Older revision		Revision as of 05:41, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [https://pdbe.org/2lby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [https://www.ebi.ac.uk/pdbsum/2lby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [https://pdbe.org/2lby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [https://www.ebi.ac.uk/pdbsum/2lby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:55, 14 June 2023

OCA — Wed, 14 Jun 2023 08:55:11 GMT

←Older revision		Revision as of 08:55, 14 June 2023
Line 1:		Line 1:

	==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==		==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==
-	<StructureSection load='2lby' size='340' side='right'caption='[[2lby~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2lby' size='340' side='right'caption='[[2lby]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [https://pdbe.org/2lby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [https://www.ebi.ac.uk/pdbsum/2lby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [https://pdbe.org/2lby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [https://www.ebi.ac.uk/pdbsum/2lby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hatzakis, E]]	+	[[Category: Hatzakis E]]
-	[[Category: Mathad, R]]	+	[[Category: Mathad R]]
-	[[Category: Yang, D]]	+	[[Category: Yang D]]
-	~~[[Category: C-myc]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G-quadruplex~~]]	+

OCA at 07:50, 9 February 2022

OCA — Wed, 09 Feb 2022 07:50:26 GMT

←Older revision		Revision as of 07:50, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2lby' size='340' side='right'caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lby' size='340' side='right'caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [~~http~~://pdbe.org/2lby PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lby PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [https://pdbe.org/2lby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [https://www.ebi.ac.uk/pdbsum/2lby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:02, 6 May 2020

OCA — Wed, 06 May 2020 07:02:17 GMT

←Older revision		Revision as of 07:02, 6 May 2020
Line 1:		Line 1:

	==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==		==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==
-	<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2lby' size='340' side='right'caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://pdbe.org/2lby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://pdbe.org/2lby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hatzakis, E]]		[[Category: Hatzakis, E]]
	[[Category: Mathad, R]]		[[Category: Mathad, R]]

OCA at 19:45, 1 August 2018

OCA — Wed, 01 Aug 2018 19:45:18 GMT

←Older revision		Revision as of 19:45, 1 August 2018
Line 1:		Line 1:
		+
	==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==		==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==
	<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://pdbe.org/2lby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://pdbe.org/2lby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lby ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:03, 9 September 2015

OCA — Wed, 09 Sep 2015 22:03:32 GMT

←Older revision		Revision as of 22:03, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://pdbe.org/2lby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lby" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:38, 19 January 2015

OCA — Mon, 19 Jan 2015 15:38:05 GMT

←Older revision		Revision as of 15:38, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hatzakis, E.]]	+	[[Category: Hatzakis, E]]
-	[[Category: Mathad, R.]]	+	[[Category: Mathad, R]]
-	[[Category: Yang, D.]]	+	[[Category: Yang, D]]
	[[Category: C-myc]]		[[Category: C-myc]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: G-quadruplex]]		[[Category: G-quadruplex]]

OCA at 21:47, 1 October 2014

OCA — Wed, 01 Oct 2014 21:47:18 GMT

←Older revision		Revision as of 21:47, 1 October 2014
Line 1:		Line 1:
-	==~~Myc~~ G-quadruplex formed at the 5'-end of ~~NHEIII~~ element==	+	==G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter==
	<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. <br>	+	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class='plainlinks'~~>[~~http://en.wikipedia.org/wiki/Glucokinase Glucokinase~~], ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2~~] ~~</span>~~</td></tr>	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xav\|1xav]], [[2l7v\|2l7v]], [[2f8u\|2f8u]], [[2m27\|2m27]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>
	<table>		<table>
Line 12:		Line 12:
	c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability.,Mathad RI, Hatzakis E, Dai J, Yang D Nucleic Acids Res. 2011 Nov 1;39(20):9023-33. Epub 2011 Jul 27. PMID:21795379<ref>PMID:21795379</ref>		c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability.,Mathad RI, Hatzakis E, Dai J, Yang D Nucleic Acids Res. 2011 Nov 1;39(20):9023-33. Epub 2011 Jul 27. PMID:21795379<ref>PMID:21795379</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:36, 1 May 2014

OCA — Thu, 01 May 2014 09:36:46 GMT

←Older revision		Revision as of 09:36, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lby' size='340' side='right' caption='[[2lby]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. <br>	+	<table><tr><td colspan='2'>[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5' runs of guanines of c-MYC promoter NHE III(1,) which have recently been shown to form in a supercoiled plasmid system in aqueous solution. We determined the NMR solution structure of the 1:2:1 parallel-stranded loop isomer, one of the two major loop isomers formed in Myc1234 in K(+) solution. This major loop isomer, although sharing the same folding structure, appears to be markedly less stable than the major loop isomer formed in the single-stranded c-MYC NHE III(1) oligonucleotide, the Myc2345 G-quadruplex. Our NMR structures indicated that the different thermostabilities of the two 1:2:1 parallel c-MYC G-quadruplexes are likely caused by the different base conformations of the single nucleotide loops. The observation of the formation of the Myc1234 G-quadruplex in the supercoiled plasmid thus points to the potential role of supercoiling in the G-quadruplex formation in promoter sequences. We also performed a systematic thermodynamic analysis of modified c-MYC NHE III(1) sequences, which provided quantitative measure of the contributions of various loop sequences to the thermostabilities of parallel-stranded G-quadruplexes. This information is important for understanding the equilibrium of promoter G-quadruplex loop isomers and for their drug targeting.		We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5' runs of guanines of c-MYC promoter NHE III(1,) which have recently been shown to form in a supercoiled plasmid system in aqueous solution. We determined the NMR solution structure of the 1:2:1 parallel-stranded loop isomer, one of the two major loop isomers formed in Myc1234 in K(+) solution. This major loop isomer, although sharing the same folding structure, appears to be markedly less stable than the major loop isomer formed in the single-stranded c-MYC NHE III(1) oligonucleotide, the Myc2345 G-quadruplex. Our NMR structures indicated that the different thermostabilities of the two 1:2:1 parallel c-MYC G-quadruplexes are likely caused by the different base conformations of the single nucleotide loops. The observation of the formation of the Myc1234 G-quadruplex in the supercoiled plasmid thus points to the potential role of supercoiling in the G-quadruplex formation in promoter sequences. We also performed a systematic thermodynamic analysis of modified c-MYC NHE III(1) sequences, which provided quantitative measure of the contributions of various loop sequences to the thermostabilities of parallel-stranded G-quadruplexes. This information is important for understanding the equilibrium of promoter G-quadruplex loop isomers and for their drug targeting.
Line 11:		Line 13:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:55, 30 April 2014

OCA — Wed, 30 Apr 2014 09:55:44 GMT

←Older revision		Revision as of 09:55, 30 April 2014
Line 4:		Line 4:
	[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. <br>		[[2lby]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBY OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lby RCSB], [http://www.ebi.ac.uk/pdbsum/2lby PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5' runs of guanines of c-MYC promoter NHE III(1,) which have recently been shown to form in a supercoiled plasmid system in aqueous solution. We determined the NMR solution structure of the 1:2:1 parallel-stranded loop isomer, one of the two major loop isomers formed in Myc1234 in K(+) solution. This major loop isomer, although sharing the same folding structure, appears to be markedly less stable than the major loop isomer formed in the single-stranded c-MYC NHE III(1) oligonucleotide, the Myc2345 G-quadruplex. Our NMR structures indicated that the different thermostabilities of the two 1:2:1 parallel c-MYC G-quadruplexes are likely caused by the different base conformations of the single nucleotide loops. The observation of the formation of the Myc1234 G-quadruplex in the supercoiled plasmid thus points to the potential role of supercoiling in the G-quadruplex formation in promoter sequences. We also performed a systematic thermodynamic analysis of modified c-MYC NHE III(1) sequences, which provided quantitative measure of the contributions of various loop sequences to the thermostabilities of parallel-stranded G-quadruplexes. This information is important for understanding the equilibrium of promoter G-quadruplex loop isomers and for their drug targeting.		We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5' runs of guanines of c-MYC promoter NHE III(1,) which have recently been shown to form in a supercoiled plasmid system in aqueous solution. We determined the NMR solution structure of the 1:2:1 parallel-stranded loop isomer, one of the two major loop isomers formed in Myc1234 in K(+) solution. This major loop isomer, although sharing the same folding structure, appears to be markedly less stable than the major loop isomer formed in the single-stranded c-MYC NHE III(1) oligonucleotide, the Myc2345 G-quadruplex. Our NMR structures indicated that the different thermostabilities of the two 1:2:1 parallel c-MYC G-quadruplexes are likely caused by the different base conformations of the single nucleotide loops. The observation of the formation of the Myc1234 G-quadruplex in the supercoiled plasmid thus points to the potential role of supercoiling in the G-quadruplex formation in promoter sequences. We also performed a systematic thermodynamic analysis of modified c-MYC NHE III(1) sequences, which provided quantitative measure of the contributions of various loop sequences to the thermostabilities of parallel-stranded G-quadruplexes. This information is important for understanding the equilibrium of promoter G-quadruplex loop isomers and for their drug targeting.