2lc6 - Revision history

OCA at 08:31, 18 January 2023

OCA — Wed, 18 Jan 2023 08:31:51 GMT

←Older revision		Revision as of 08:31, 18 January 2023
Line 1:		Line 1:

	==Solution structure of Par-6 Q144C/L164C==		==Solution structure of Par-6 Q144C/L164C==
-	<StructureSection load='2lc6' size='340' side='right'caption='[[2lc6~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lc6' size='340' side='right'caption='[[2lc6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lc7\|2lc7]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [https://pdbe.org/2lc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [https://pdbe.org/2lc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O97111_DROME O97111_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Peterson FC]]
-	[[Category: Volkman~~, B F~~]]	+	[[Category: Volkman BF]]
-	[[Category: Whitney~~, D S]]~~	+	[[Category: Whitney DS]]
-	~~[[Category: Cdc42]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Crib]]~~	+
-	~~[[Category: Pdz domain~~]]	+

OCA at 07:40, 14 April 2021

OCA — Wed, 14 Apr 2021 07:40:19 GMT

←Older revision		Revision as of 07:40, 14 April 2021
Line 1:		Line 1:

	==Solution structure of Par-6 Q144C/L164C==		==Solution structure of Par-6 Q144C/L164C==
-	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lc6' size='340' side='right'caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lc7\|2lc7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [~~http~~://pdbe.org/2lc6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [https://pdbe.org/2lc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Peterson, F C]]		[[Category: Peterson, F C]]
	[[Category: Volkman, B F]]		[[Category: Volkman, B F]]

OCA at 19:54, 1 August 2018

OCA — Wed, 01 Aug 2018 19:54:32 GMT

←Older revision		Revision as of 19:54, 1 August 2018
Line 1:		Line 1:
		+
	==Solution structure of Par-6 Q144C/L164C==		==Solution structure of Par-6 Q144C/L164C==
	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://pdbe.org/2lc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://pdbe.org/2lc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:28, 11 September 2015

OCA — Fri, 11 Sep 2015 15:28:40 GMT

←Older revision		Revision as of 15:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://pdbe.org/2lc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lc6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Peterson, F C]]		[[Category: Peterson, F C]]
	[[Category: Volkman, B F]]		[[Category: Volkman, B F]]

OCA at 05:48, 22 December 2014

OCA — Mon, 22 Dec 2014 05:48:43 GMT

←Older revision		Revision as of 05:48, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>	+	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	A Conformational Switch in the CRIB-PDZ Module of Par-6.,Whitney DS, Peterson FC, Volkman BF Structure. 2011 Nov 9;19(11):1711-22. PMID:22078569<ref>PMID:22078569</ref>		A Conformational Switch in the CRIB-PDZ Module of Par-6.,Whitney DS, Peterson FC, Volkman BF Structure. 2011 Nov 9;19(11):1711-22. PMID:22078569<ref>PMID:22078569</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Peterson, F C.]]	+	[[Category: Peterson, F C]]
-	[[Category: Volkman, B F.]]	+	[[Category: Volkman, B F]]
-	[[Category: Whitney, D S.]]	+	[[Category: Whitney, D S]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Crib]]		[[Category: Crib]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]

OCA at 09:48, 1 May 2014

OCA — Thu, 01 May 2014 09:48:01 GMT

←Older revision		Revision as of 09:48, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>	+	<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>
-	<b>[[Related_structure\|Related:]]</b> [[2lc7\|2lc7]]<br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lc7\|2lc7]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG5884, Dmel_CG5884, par-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.		Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.
Line 12:		Line 15:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:10, 30 April 2014

OCA — Wed, 30 Apr 2014 10:10:13 GMT

←Older revision		Revision as of 10:10, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>		[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>
-	<b>Related:</b> [[2lc7\|2lc7]]<br>	+	<b>[[Related_structure\|Related:]]</b> [[2lc7\|2lc7]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc6 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.		Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.

OCA at 08:31, 30 April 2014

OCA — Wed, 30 Apr 2014 08:31:05 GMT

←Older revision		Revision as of 08:31, 30 April 2014
Line 1:		Line 1:
-	[[~~Image:~~2lc6.~~png~~\|~~left\|200px~~]]	+	==Solution structure of Par-6 Q144C/L164C==
		+	<StructureSection load='2lc6' size='340' side='right' caption='[[2lc6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. <br>
		+	<b>Related:</b> [[2lc7\|2lc7]]<br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.

-	<!--	+	A Conformational Switch in the CRIB-PDZ Module of Par-6.,Whitney DS, Peterson FC, Volkman BF Structure. 2011 Nov 9;19(11):1711-22. PMID:22078569<ref>PMID:22078569</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2lc6"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2lc6\| PDB=2lc6 \| SCENE= }}~~	+

-	~~===Solution structure of Par-6 Q144C~~/~~L164C===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-		+	<references/>
-	~~<!--~~	+	__TOC__
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22078569}}, adds~~ the ~~Publication Abstract to the page~~	+	</StructureSection>
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22078569 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22078569}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~[[2lc6]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA].~~	+
-		+
-	~~==Reference==~~	+
-	<~~ref group="xtra">PMID:022078569</ref><references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Peterson, F C.]]		[[Category: Peterson, F C.]]

OCA at 08:07, 7 December 2011

OCA — Wed, 07 Dec 2011 08:07:38 GMT

←Older revision		Revision as of 08:07, 7 December 2011
Line 1:		Line 1:
-	[[Image:2lc6.~~jpg~~\|left\|200px]]	+	[[Image:2lc6.png\|left\|200px]]

	<!--		<!--

OCA at 06:20, 30 November 2011

OCA — Wed, 30 Nov 2011 06:20:36 GMT

←Older revision		Revision as of 06:20, 30 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lc6.jpg\|left\|200px]]

-	The ~~entry 2lc6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lc6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lc6\| PDB=2lc6 \| SCENE= }}

-	~~Authors: Volkman, B.F., Whitney, D.S., Peterson, F.C.~~	+	===Solution structure of Par-6 Q144C/L164C===

-	~~Description~~: ~~Solution~~ structure ~~of Par~~-~~6 Q144C~~/~~L164C~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22078569}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22078569 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22078569}}
		+
		+	==About this Structure==
		+	[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022078569</ref><references group="xtra"/>
		+	[[Category: Drosophila melanogaster]]
		+	[[Category: Peterson, F C.]]
		+	[[Category: Volkman, B F.]]
		+	[[Category: Whitney, D S.]]
		+	[[Category: Cdc42]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Crib]]
		+	[[Category: Pdz domain]]