2lf8 - Revision history

OCA at 05:42, 15 May 2024

OCA — Wed, 15 May 2024 05:42:32 GMT

←Older revision		Revision as of 05:42, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [https://pdbe.org/2lf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [https://pdbe.org/2lf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:57, 15 February 2023

OCA — Wed, 15 Feb 2023 10:57:04 GMT

←Older revision		Revision as of 10:57, 15 February 2023
Line 1:		Line 1:

	==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==		==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==
-	<StructureSection load='2lf8' size='340' side='right'caption='[[2lf8~~]], [[NMR_Ensembles_of_Models \| 19 NMR models~~]]' scene=''>	+	<StructureSection load='2lf8' size='340' side='right'caption='[[2lf8]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lf7\|2lf7]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [https://pdbe.org/2lf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [https://pdbe.org/2lf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ETV6_MOUSE ETV6_MOUSE]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.	+	[https://www.uniprot.org/uniprot/ETV6_MOUSE ETV6_MOUSE] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Graves, B J]]~~	+	[[Category: Coyne III H]]
-	~~[[Category: Green, S M~~]]	+	[[Category: Graves BJ]]
-	[[Category: III, H ~~Coyne~~]]	+	[[Category: Green SM]]
-	[[Category: ~~Mcintosh, L P~~]]	+	[[Category: Mcintosh LP]]
-	[[Category: ~~Auto-inhibition~~]]	+
-	[[Category: ~~Transcription~~]]	+

OCA at 10:09, 12 May 2021

OCA — Wed, 12 May 2021 10:09:50 GMT

←Older revision		Revision as of 10:09, 12 May 2021
Line 1:		Line 1:

	==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==		==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==
-	<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>	+	<StructureSection load='2lf8' size='340' side='right'caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lf7\|2lf7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [~~http~~://pdbe.org/2lf8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [https://pdbe.org/2lf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ETV6_MOUSE ETV6_MOUSE]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.	+	[[https://www.uniprot.org/uniprot/ETV6_MOUSE ETV6_MOUSE]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Graves, B J]]		[[Category: Graves, B J]]

OCA at 20:11, 1 August 2018

OCA — Wed, 01 Aug 2018 20:11:27 GMT

←Older revision		Revision as of 20:11, 1 August 2018
Line 1:		Line 1:
		+
	==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==		==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==
	<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://pdbe.org/2lf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://pdbe.org/2lf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:11, 11 September 2015

OCA — Fri, 11 Sep 2015 02:11:09 GMT

←Older revision		Revision as of 02:11, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://pdbe.org/2lf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lf8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Graves, B J]]		[[Category: Graves, B J]]
	[[Category: Green, S M]]		[[Category: Green, S M]]

OCA at 09:38, 25 December 2014

OCA — Thu, 25 Dec 2014 09:38:39 GMT

←Older revision		Revision as of 09:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETV6_MOUSE ETV6_MOUSE]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain.,Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP J Mol Biol. 2012 Aug 3;421(1):67-84. Epub 2012 May 12. PMID:22584210<ref>PMID:22584210</ref>		Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain.,Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP J Mol Biol. 2012 Aug 3;421(1):67-84. Epub 2012 May 12. PMID:22584210<ref>PMID:22584210</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Graves, B J.]]	+	[[Category: Graves, B J]]
-	[[Category: Green, S M.]]	+	[[Category: Green, S M]]
-	[[Category: III, H Coyne.]]	+	[[Category: III, H Coyne]]
-	[[Category: Mcintosh, L P.]]	+	[[Category: Mcintosh, L P]]
	[[Category: Auto-inhibition]]		[[Category: Auto-inhibition]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 10:43, 28 May 2014

OCA — Wed, 28 May 2014 10:43:49 GMT

←Older revision		Revision as of 10:43, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2lf8.~~png~~\|~~left~~\|~~200px~~]]	+	==Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458==
		+	<StructureSection load='2lf8' size='340' side='right' caption='[[2lf8]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lf7\|2lf7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Etv6, mouse ETV6, Tel, Tel1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf8 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ETV6 (or TEL), a transcriptional repressor belonging to the ETS family, is frequently involved in chromosomal translocations linked with human cancers. It displays a DNA-binding mode distinct from other ETS proteins due to the presence of a self-associating PNT domain. In this study, we used NMR spectroscopy to dissect the structural and dynamic bases for the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS domain. The C-terminal inhibitory domain (CID) contains two helices, H4 and H5, which sterically block the DNA-binding interface of the ETS domain. Importantly, these appended helices are only marginally stable as revealed by amide hydrogen exchange and (15)N relaxation measurements. The CID is thus poised to undergo a facile conformational change as required for DNA binding. The CID also dampens millisecond timescale motions of the ETS domain hypothesized to be critical for the recognition of specific ETS target sequences. This work illustrates the use of appended sequences on conserved structural domains to generate biological diversity and complements previous studies of the allosteric mechanism of ETS1 autoinhibition to reveal both common and divergent features underlying the regulation of DNA binding by ETS transcription factors.

-	~~{{STRUCTURE_2lf8\| PDB=2lf8 \| SCENE= }}~~	+	Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain.,Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP J Mol Biol. 2012 Aug 3;421(1):67-84. Epub 2012 May 12. PMID:22584210<ref>PMID:22584210</ref>

-	~~===Intramolecular regulation~~ of the ~~ETS Domain within ETV6 sequence R335 to R458===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22584210}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2lf8]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022584210<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Graves, B J.]]		[[Category: Graves, B J.]]

OCA at 06:29, 25 July 2012

OCA — Wed, 25 Jul 2012 06:29:32 GMT

←Older revision		Revision as of 06:29, 25 July 2012
Line 1:		Line 1:
-	[[Image:2lf8.~~jpg~~\|left\|200px]]	+	[[Image:2lf8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lf8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lf8\| PDB=2lf8 \| SCENE= }}		{{STRUCTURE_2lf8\| PDB=2lf8 \| SCENE= }}

	===Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458===		===Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458===

		+	{{ABSTRACT_PUBMED_22584210}}

	==About this Structure==		==About this Structure==
	[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA].		[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022584210</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Graves, B J.]]		[[Category: Graves, B J.]]

OCA at 06:08, 23 May 2012

OCA — Wed, 23 May 2012 06:08:16 GMT

←Older revision		Revision as of 06:08, 23 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lf8.jpg\|left\|200px]]

-	The ~~entry 2lf8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lf8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lf8\| PDB=2lf8 \| SCENE= }}

-	~~Authors: Coyne III, H., Green, S.M., Graves, B.J., Mcintosh, L.P.~~	+	===Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458===

-	~~Description: Intramolecular regulation of the ETS Domain within ETV6~~ sequence ~~R335 to R458~~	+
		+	==About this Structure==
		+	[[2lf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF8 OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Graves, B J.]]
		+	[[Category: Green, S M.]]
		+	[[Category: III, H Coyne.]]
		+	[[Category: Mcintosh, L P.]]
		+	[[Category: Auto-inhibition]]
		+	[[Category: Transcription]]

OCA at 05:59, 20 July 2011

OCA — Wed, 20 Jul 2011 05:59:29 GMT

←Older revision		Revision as of 05:59, 20 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lf8 is ON HOLD	+	The entry 2lf8 is ON HOLD until Paper Publication

-	Authors: Coyne, H.~~, III~~, Green, S.M., Graves, B.J., ~~McIntosh~~, L.P.	+	Authors: Coyne III, H., Green, S.M., Graves, B.J., Mcintosh, L.P.

-	Description: R458	+	Description: Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458