2lgy - Revision history

OCA at 05:43, 15 May 2024

OCA — Wed, 15 May 2024 05:43:36 GMT

←Older revision		Revision as of 05:43, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [https://pdbe.org/2lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [https://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [https://pdbe.org/2lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [https://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2lgy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2lgy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:59, 15 February 2023

OCA — Wed, 15 Feb 2023 10:59:52 GMT

←Older revision		Revision as of 10:59, 15 February 2023
Line 1:		Line 1:

	==Ubiquitin-like domain from HOIL-1==		==Ubiquitin-like domain from HOIL-1==
-	<StructureSection load='2lgy' size='340' side='right'caption='[[2lgy~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lgy' size='340' side='right'caption='[[2lgy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [https://pdbe.org/2lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [https://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [https://pdbe.org/2lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [https://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis.	+	[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN] Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>	+	[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beasley~~, S A~~]]	+	[[Category: Beasley SA]]
-	[[Category: Shaw~~, G S]]~~	+	[[Category: Shaw GS]]
-	~~[[Category: E3 ligase]]~~	+
-	~~[[Category: Hoip]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Ubiquitin]]~~	+
-	~~[[Category: Ubld~~]]	+

OCA at 10:10, 12 May 2021

OCA — Wed, 12 May 2021 10:10:44 GMT

←Older revision		Revision as of 10:10, 12 May 2021
Line 1:		Line 1:

	==Ubiquitin-like domain from HOIL-1==		==Ubiquitin-like domain from HOIL-1==
-	<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lgy' size='340' side='right'caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [~~http~~://pdbe.org/2lgy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [https://pdbe.org/2lgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [https://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis.	+	[[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>	+	[[https://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Beasley, S A]]		[[Category: Beasley, S A]]
	[[Category: Shaw, G S]]		[[Category: Shaw, G S]]

OCA at 20:09, 1 August 2018

OCA — Wed, 01 Aug 2018 20:09:01 GMT

←Older revision		Revision as of 20:09, 1 August 2018
Line 1:		Line 1:
		+
	==Ubiquitin-like domain from HOIL-1==		==Ubiquitin-like domain from HOIL-1==
	<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [http://pdbe.org/2lgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [http://www.ebi.ac.uk/pdbsum/2lgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [http://pdbe.org/2lgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [http://www.ebi.ac.uk/pdbsum/2lgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 11:04, 11 September 2015

OCA — Fri, 11 Sep 2015 11:04:33 GMT

←Older revision		Revision as of 11:04, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [http://www.ebi.ac.uk/pdbsum/2lgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [http://pdbe.org/2lgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [http://www.ebi.ac.uk/pdbsum/2lgy PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lgy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Beasley, S A]]		[[Category: Beasley, S A]]
	[[Category: Shaw, G S]]		[[Category: Shaw, G S]]

OCA at 22:19, 3 January 2015

OCA — Sat, 03 Jan 2015 22:19:54 GMT

←Older revision		Revision as of 22:19, 3 January 2015
Line 1:		Line 1:
-	[[~~Image:~~2lgy.~~png~~\|~~left\|200px~~]]	+	==Ubiquitin-like domain from HOIL-1==
		+	<StructureSection load='2lgy' size='340' side='right' caption='[[2lgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGY FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgy RCSB], [http://www.ebi.ac.uk/pdbsum/2lgy PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HOIL1_HUMAN HOIL1_HUMAN]] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The E3 ligases HOIL-1 and parkin are each comprised of an N-terminal ubiquitin-like (Ubl) domain followed by a zinc-binding region and C-terminal RING-In-between-RING-RING domains. These two proteins, involved in the ubiquitin-mediated degradation pathway, are the only two known E3 ligases to share this type of multidomain architecture. Further, the Ubl domain of both HOIL-1 and parkin has been shown to interact with the S5a subunit of the 26S proteasome. The solution structure of the HOIL-1 Ubl domain was solved using NMR spectroscopy to compare it with that of parkin to determine the structural elements responsible for S5a intermolecular interactions. The final ensemble of 20 structures had a beta-grasp Ubl-fold with an overall backbone RMSD of 0.59 +/- 0.10 A in the structured regions between I55 and L131. HOIL-1 had a unique extension of both beta1 and beta2 sheets compared to parkin and other Ubl domains, a result of a four-residue insertion in this region. A similar 15-residue hydrophobic core in the HOIL-1 Ubl domain resulted in a comparable stability to the parkin Ubl, but significantly lower than that observed for ubiquitin. A comparison with parkin and other Ubl domains indicates that HOIL-1 likely uses a conserved hydrophobic patch (W58, V102, Y127, Y129) found on the beta1 face, the beta3-beta4 loop and beta5, as well as a C-terminal basic residue (R134) to recruit the S5a subunit as part of the ubiquitin-mediated proteolysis pathway.

-	~~{{STRUCTURE_2lgy\| PDB=2lgy \| SCENE= }}~~	+	Solution structure of the E3 ligase HOIL-1 Ubl domain.,Beasley SA, Safadi SS, Barber KR, Shaw GS Protein Sci. 2012 Jul;21(7):1085-92. doi: 10.1002/pro.2080. Epub 2012 May 24. PMID:22517668<ref>PMID:22517668</ref>

-	~~===Ubiquitin-like domain from HOIL-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22517668}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2lgy]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022517668<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Beasley, S A.]]	+	[[Category: Beasley, S A]]
-	[[Category: Shaw, G S.]]	+	[[Category: Shaw, G S]]
	[[Category: E3 ligase]]		[[Category: E3 ligase]]
	[[Category: Hoip]]		[[Category: Hoip]]

OCA at 04:54, 27 June 2012

OCA — Wed, 27 Jun 2012 04:54:57 GMT

←Older revision		Revision as of 04:54, 27 June 2012
Line 1:		Line 1:
-	[[Image:2lgy.~~jpg~~\|left\|200px]]	+	[[Image:2lgy.png\|left\|200px]]

	{{STRUCTURE_2lgy\| PDB=2lgy \| SCENE= }}		{{STRUCTURE_2lgy\| PDB=2lgy \| SCENE= }}

OCA at 07:49, 20 June 2012

OCA — Wed, 20 Jun 2012 07:49:55 GMT

←Older revision		Revision as of 07:49, 20 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lgy.jpg\|left\|200px]]

-	~~The entry~~ 2lgy ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lgy\| PDB=2lgy \| SCENE= }}

-	~~Authors: Beasley, S.A., Shaw, G.S.~~	+	===Ubiquitin-like domain from HOIL-1===

-	~~Description~~: ~~Ubiquitin-like domain~~ from ~~HOIL~~-1	+	{{ABSTRACT_PUBMED_22517668}}
		+
		+	==About this Structure==
		+	[[2lgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022517668</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Beasley, S A.]]
		+	[[Category: Shaw, G S.]]
		+	[[Category: E3 ligase]]
		+	[[Category: Hoip]]
		+	[[Category: Ligase]]
		+	[[Category: Ubiquitin]]
		+	[[Category: Ubld]]

OCA at 05:19, 21 September 2011

OCA — Wed, 21 Sep 2011 05:19:00 GMT

←Older revision		Revision as of 05:19, 21 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lgy is ON HOLD	+	The entry 2lgy is ON HOLD until Paper Publication

	Authors: Beasley, S.A., Shaw, G.S.		Authors: Beasley, S.A., Shaw, G.S.

	Description: Ubiquitin-like domain from HOIL-1		Description: Ubiquitin-like domain from HOIL-1

OCA at 05:38, 17 August 2011

OCA — Wed, 17 Aug 2011 05:38:29 GMT

←Older revision		Revision as of 05:38, 17 August 2011
Line 3:		Line 3:
	The entry 2lgy is ON HOLD		The entry 2lgy is ON HOLD

-	Authors: Beasley, S.A., Shaw, G.S~~., Beasley, S.A~~.	+	Authors: Beasley, S.A., Shaw, G.S.

	Description: Ubiquitin-like domain from HOIL-1		Description: Ubiquitin-like domain from HOIL-1