2lia - Revision history

OCA at 05:44, 15 May 2024

OCA — Wed, 15 May 2024 05:44:03 GMT

←Older revision		Revision as of 05:44, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [https://pdbe.org/2lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [https://www.ebi.ac.uk/pdbsum/2lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [https://pdbe.org/2lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [https://www.ebi.ac.uk/pdbsum/2lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:00, 14 June 2023

OCA — Wed, 14 Jun 2023 09:00:58 GMT

←Older revision		Revision as of 09:00, 14 June 2023
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	==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==		==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==
-	<StructureSection load='2lia' size='340' side='right'caption='[[2lia~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2lia' size='340' side='right'caption='[[2lia]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [https://pdbe.org/2lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [https://www.ebi.ac.uk/pdbsum/2lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [https://pdbe.org/2lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [https://www.ebi.ac.uk/pdbsum/2lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ganguly, M]]	+	[[Category: Ganguly M]]
-	[[Category: Gold, B]]	+	[[Category: Gold B]]
-	[[Category: Stone~~, M P~~]]	+	[[Category: Stone MP]]
-	[[Category: Szulik~~, M W~~]]	+	[[Category: Szulik MW]]
-	[[Category: Wang, R]]	+	[[Category: Wang R]]
-	~~[[Category: Dna~~]]	+

OCA at 07:52, 9 February 2022

OCA — Wed, 09 Feb 2022 07:52:11 GMT

←Older revision		Revision as of 07:52, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2lia' size='340' side='right'caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2lia' size='340' side='right'caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [~~http~~://pdbe.org/2lia PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lia PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [https://pdbe.org/2lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [https://www.ebi.ac.uk/pdbsum/2lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:05, 6 May 2020

OCA — Wed, 06 May 2020 07:05:19 GMT

←Older revision		Revision as of 07:05, 6 May 2020
Line 1:		Line 1:

	==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==		==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==
-	<StructureSection load='2lia' size='340' side='right' caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2lia' size='340' side='right'caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://pdbe.org/2lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://pdbe.org/2lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ganguly, M]]		[[Category: Ganguly, M]]
	[[Category: Gold, B]]		[[Category: Gold, B]]

OCA at 19:22, 1 August 2018

OCA — Wed, 01 Aug 2018 19:22:11 GMT

←Older revision		Revision as of 19:22, 1 August 2018
Line 1:		Line 1:
		+
	==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==		==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==
	<StructureSection load='2lia' size='340' side='right' caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2lia' size='340' side='right' caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://pdbe.org/2lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://pdbe.org/2lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lia ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:28, 11 September 2015

OCA — Fri, 11 Sep 2015 07:28:50 GMT

←Older revision		Revision as of 07:28, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://pdbe.org/2lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lia" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:17, 19 January 2015

OCA — Mon, 19 Jan 2015 13:17:27 GMT

←Older revision		Revision as of 13:17, 19 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2lia\| PDB=2lia \| SCENE= }}~~	+	==Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct==
-	===Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct===	+	<StructureSection load='2lia' size='340' side='right' caption='[[2lia]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_24131376}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LIA FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LA:2-AMINO-5-(AMINOMETHYL)-7-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE'>2LA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lia RCSB], [http://www.ebi.ac.uk/pdbsum/2lia PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A cationic 7-aminomethyl-7-deaza-2'-deoxyguanosine (7amG) was incorporated site-specifically into the self-complementary duplex d(G1A2G3A4X5C6G7C8T9C10T11C12)2 (X = 7amG). This construct placed two positively charged amines adjacent to the major groove edges of two symmetry-related guanines, providing a model for probing how cation binding in the major groove modulates the structure and stability of DNA. Molecular dynamics calculations restrained by nuclear magnetic resonance (NMR) data revealed that the tethered cationic amines were in plane with the modified base pairs. The tethered amines did not form salt bridges to the phosphodiester backbone. There was also no indication of the amines being capable of hydrogen bonding to flanking DNA bases. NMR spectroscopy as a function of temperature revealed that the X5 imino resonance remained sharp at 55 degrees C. Additionally, two 5'-neighboring base pairs, A4:T9 and G3:C10, were stabilized with respect to the exchange of their imino protons with solvent. The equilibrium constant for base pair opening at the A4:T9 base pair determined by magnetization transfer from water in the absence and presence of added ammonia base catalyst decreased for the modified duplex compared to that of the A4:T9 base pair in the unmodified duplex, which confirmed that the overall fraction of the A4:T9 base pair in the open state of the modified duplex decreased. This was also observed for the G3:C10 base pair, where alphaKop for the G3:C10 base pair in the modified duplex was 3.0 x 106 versus 4.1 x 106 for the same base pair in the unmodified duplex. In contrast, equilibrium constants for base pair opening at the X5:C8 and C6:G7 base pairs did not change at 15 degrees C. These results argue against the notion that electrostatic interactions with DNA are entirely entropic and suggest that major groove cations can stabilize DNA via enthalpic contributions to the free energy of duplex formation.

-	~~==About this Structure==~~	+	Site-Specific Stabilization of DNA by a Tethered Major Groove Amine, 7-Aminomethyl-7-deaza-2'-deoxyguanosine.,Szulik MW, Voehler MW, Ganguly M, Gold B, Stone MP Biochemistry. 2013 Oct 16. PMID:24131376<ref>PMID:24131376</ref>
-	~~[[2lia]] is~~ a 2 ~~chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2LIA OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024131376</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Ganguly, M.]]	+	== References ==
-	[[Category: Gold, B.]]	+	<references/>
-	[[Category: Stone, M P.]]	+	__TOC__
-	[[Category: Szulik, M W.]]	+	</StructureSection>
-	[[Category: Wang, R.]]	+	[[Category: Ganguly, M]]
		+	[[Category: Gold, B]]
		+	[[Category: Stone, M P]]
		+	[[Category: Szulik, M W]]
		+	[[Category: Wang, R]]
	[[Category: Dna]]		[[Category: Dna]]

OCA at 11:43, 20 November 2013

OCA — Wed, 20 Nov 2013 11:43:47 GMT

←Older revision		Revision as of 11:43, 20 November 2013
Line 1:		Line 1:
-	[[Image:2lia.jpg\|left\|200px]]
-
	{{STRUCTURE_2lia\| PDB=2lia \| SCENE= }}		{{STRUCTURE_2lia\| PDB=2lia \| SCENE= }}
-
	===Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct===		===Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct===
-		+	{{ABSTRACT_PUBMED_24131376}}

	==About this Structure==		==About this Structure==
	[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA].		[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024131376</ref><references group="xtra"/><references/>
	[[Category: Ganguly, M.]]		[[Category: Ganguly, M.]]
	[[Category: Gold, B.]]		[[Category: Gold, B.]]

OCA at 05:15, 29 August 2012

OCA — Wed, 29 Aug 2012 05:15:41 GMT

←Older revision		Revision as of 05:15, 29 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lia.jpg\|left\|200px]]

-	~~The entry~~ 2lia ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lia\| PDB=2lia \| SCENE= }}

-	~~Authors: Szulik, M.W., Ganguly, M., Wang, R., Gold, B., Stone, M.P.~~	+	===Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct===

-	~~Description: Solution NMR structure of~~ a ~~DNA dodecamer containing the 7-aminomethyl-7-deaza-~~2'-~~deoxyguanosine adduct~~	+
		+	==About this Structure==
		+	[[2lia]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LIA OCA].
		+	[[Category: Ganguly, M.]]
		+	[[Category: Gold, B.]]
		+	[[Category: Stone, M P.]]
		+	[[Category: Szulik, M W.]]
		+	[[Category: Wang, R.]]
		+	[[Category: Dna]]

OCA at 11:02, 9 November 2011

OCA — Wed, 09 Nov 2011 11:02:43 GMT

←Older revision		Revision as of 11:02, 9 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lia is ON HOLD	+	The entry 2lia is ON HOLD until Paper Publication

	Authors: Szulik, M.W., Ganguly, M., Wang, R., Gold, B., Stone, M.P.		Authors: Szulik, M.W., Ganguly, M., Wang, R., Gold, B., Stone, M.P.

	Description: Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct		Description: Solution NMR structure of a DNA dodecamer containing the 7-aminomethyl-7-deaza-2'-deoxyguanosine adduct